Share：
Share this content in WeChat
X
[Chinese][PDF]91399
• Stroke MRI •
The comparative study of ischemic stroke early DKI, DWI lesions predicted the final transition
SUN Hai-zhen  ZHANG Hui  NI Hong-yan  SHEN Wen  YIN Jian-zhong  ZHANG Shun  ZHU Wen-zhen 

DOI:10.12015/issn.1674-8034.2016.10.003.


[Abstract] Objective: Diffusion kurtosis imaging (DKI) has lately been postulated as a complementary MRI method to stratify the heterogeneous damaged DWI lesion. Compare the ability of DWI and DKI predicting lesion transformation, to supplement the precise definition of infarct core area.Materials and Methods: Eighteen cases of ischemic stroke were recruited for our study, who had infarct on DWI at baseline, and had follow-up MR scans. Pre-defined target imaging time points, obtained on a 3.0 T MR scanner, were<48 h and≥30 d post-stroke. Drawing the range of lesion from acute DKI (MK mapping), DWI and final T2WI, and calculate the lesion volume. Relationship between baseline DWI, MK map and follow-up T2WI was analyzed using Spearman rank-order correlation test, and Kruskal-Wallis H test was used to compare the volumes among three groups.Results: There was no difference among the volume of DWI, MK map and follow-up T2WI (H=5.819, P>0.05). Follow-up T2WI infarct volume (766.3±1406.4) mm3 was correlated with both volume predicted with the MK map(905.8±1605.4) mm3 and baseline DWI volume (1642.5±3296.9) mm3, which showed baseline DKI (MK mapping) infarct volume had stronger correlation with final T2 infarct volume than DWI (r=0.977, P<0.001; r=0.548, P<0.05, respectively).Conclusion: Final infarct volume was closer to the lesion shown on DKI than on DWI, DKI can predict the final transition more accuratly.
[Keywords] Stroke；Diffusion kurtosis imaging；Diffusion weighted imaging；Magnetic resonance imaging；Lesion volume

SUN Hai-zhen The First Central Clinical College of Tianjin Medical University, Tianjin 300192, China

ZHANG Hui The First Central Clinical College of Tianjin Medical University, Tianjin 300192, China

NI Hong-yan Department of Radiology, Tianjin First Central Hospital, Tianjin Medical Imaging Institute, Tianjin 300192, China

SHEN Wen Department of Radiology, Tianjin First Central Hospital, Tianjin Medical Imaging Institute, Tianjin 300192, China

YIN Jian-zhong* Department of Radiology, Tianjin First Central Hospital, Tianjin Medical Imaging Institute, Tianjin 300192, China

ZHANG Shun Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

ZHU Wen-zhen Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

*Correspondence to: Yin JZ, E-mail: yin3000@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This study was supported by National "Twelfth Five-Year" Program of Science & Technology Support No. 2011BAI08B10 Tianjin Science and Technology Support Project No. 15ZCZDSY00520 Tianjin Bureau of Public Health No. 13KG107
Received  2016-08-08
Accepted  2016-09-23
DOI: 10.12015/issn.1674-8034.2016.10.003
DOI:10.12015/issn.1674-8034.2016.10.003.

[1]
Li F, Liu KF, Silva MD, et al. Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats: correlation with histopathology. Stroke, 2000,31(4): 946-954.
[2]
Fiehler J, Foth M, Kucinski T, et al. Severe ADC decreases do not predict irreversible tissue damage in humans. Stroke, 2002, 33(1):79-86.
[3]
Labeyrie MA, Turc G, Hess A, et al. Diffusion lesion reversal after thrombolysis: a MR correlate of early neurological improvement. Stroke, 2012, 43(11): 2986-2991.
[4]
Wu EX, Cheung MM. MR diffusion kurtosis imaging for neural tissue characterization. NMR Biomed, 2010, 23(7): 836-848.
[5]
Sun PZ, Wang Y, Mandeville E, et al. Validation of fast diffusion kurtosis MRI for imaging acute ischemia in a rodent model of stroke. NMR Biomed, 2014, 27(11): 1413-1418.
[6]
Hui ES, Du F, Huang S, et al. Spatiotemporal dynamics of diffusional kurtosis, mean diffusivity and perfusion changes in experimental stroke. Brain Res, 2012, 1451(1): 100-109.
[7]
Cheung JS, Wang E, Lo EH, et al. Stratification of heterogeneous diffusion MRI ischemic lesion with kurtosis imaging: evaluation of mean diffusion and kurtosis MRI mismatch in an animal model of transient focal ischemia. Stroke, 2012, 43(8): 2252-2254.
[8]
Shobha N, Buchan AM, Hill MD. Thrombolysis at 3-4.5 hours after acute ischemic stroke onset--evidence from the canadian alteplase for stroke effectiveness study (CASES) registry. Cerebrovasc Dis, 2011,31(3): 223-228.
[9]
Copen WA, Rezai GL, Barak ER, et al. Existence of the diffusion-perfusion mismatch within 24 hours after onset of acute stroke: dependence on proximal arterial occlusion. Radiology, 2009, 250(3):878-886.
[10]
Gonzalez RG. Imaging-guided acute ischemic stroke therapy: From "time is brain" to "physiology is brain". AJNR Am J Neuroradiol, 2006, 27(4): 728-735.
[11]
Campbell BC, Purushotham A, Christensen S, et al. The infarct core is well represented by the acute diffusion lesion: sustained reversal is infrequent. J Cereb Blood Flow Metab, 2012, 32(1): 50-56.
[12]
党玉雪，王晓明.磁共振新技术DKI和IVIM在中枢神经系统的研究现状.磁共振成像, 2015, 6(2): 145-150.
[13]
岳倩，徐香玖，王治民,等.扩散张量成像和动脉自旋标记对急性缺血性脑卒中脑损伤的评价.磁共振成像, 2015, 6(7): 486-490.
[14]
Olivot JM, Marks MP. Magnetic resonance imaging in the evaluation of acute stroke. Top Magn Reson Imaging, 2008, 19(5): 225-230.
[15]
Jensen JH, Falangola MF, Hu C, et al. Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction. NMR Biomed, 2011, 24(5): 452-457.
[16]
Jensen JH, Helpern JA, Ramani A, et al. Diffusional kurtosis imaging: the quantification of non-gaussian water diffusion by means of magnetic resonance imaging. Magn Reson Med, 2005,53(6): 1432-1440.
[17]
van Pul C, Jennekens W, Nicolay K, et al. Ischemia-induced ADC changes are larger than osmotically-induced ADC changes in a neonatal rat hippocampus model. Magn Reson Med, 2005, 53(2):348-355.
[18]
Zhang S, Yao Y, Shi J, et al. The temporal evolution of diffusional kurtosis imaging in an experimental middle cerebral artery occlusion (MCAO) model. Magn Reson Imaging, 2016, 34(7): 889-895.
[19]
张顺，姚义好，张水霞,等.脑梗死不同时期的MR扩散峰度成像表现.中华放射学杂志, 2014, 48(6): 443-447.

PREV Degree centrality in the human functional connectome of basal ganlia stroke patients
NEXT The study of carotid plaque characteristic of the low risk and high risk of acute ischemic stroke based on essen stroke risk score system
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn