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• Stroke MRI •
The comparative study of ischemic stroke early DKI, DWI lesions predicted the final transition
SUN Hai-zhen  ZHANG Hui  NI Hong-yan  SHEN Wen  YIN Jian-zhong  ZHANG Shun  ZHU Wen-zhen 

DOI:10.12015/issn.1674-8034.2016.10.003.


[Abstract] Objective: Diffusion kurtosis imaging (DKI) has lately been postulated as a complementary MRI method to stratify the heterogeneous damaged DWI lesion. Compare the ability of DWI and DKI predicting lesion transformation, to supplement the precise definition of infarct core area.Materials and Methods: Eighteen cases of ischemic stroke were recruited for our study, who had infarct on DWI at baseline, and had follow-up MR scans. Pre-defined target imaging time points, obtained on a 3.0 T MR scanner, were<48 h and≥30 d post-stroke. Drawing the range of lesion from acute DKI (MK mapping), DWI and final T2WI, and calculate the lesion volume. Relationship between baseline DWI, MK map and follow-up T2WI was analyzed using Spearman rank-order correlation test, and Kruskal-Wallis H test was used to compare the volumes among three groups.Results: There was no difference among the volume of DWI, MK map and follow-up T2WI (H=5.819, P>0.05). Follow-up T2WI infarct volume (766.3±1406.4) mm3 was correlated with both volume predicted with the MK map(905.8±1605.4) mm3 and baseline DWI volume (1642.5±3296.9) mm3, which showed baseline DKI (MK mapping) infarct volume had stronger correlation with final T2 infarct volume than DWI (r=0.977, P<0.001; r=0.548, P<0.05, respectively).Conclusion: Final infarct volume was closer to the lesion shown on DKI than on DWI, DKI can predict the final transition more accuratly.
[Keywords] Stroke；Diffusion kurtosis imaging；Diffusion weighted imaging；Magnetic resonance imaging；Lesion volume

SUN Hai-zhen The First Central Clinical College of Tianjin Medical University, Tianjin 300192, China

ZHANG Hui The First Central Clinical College of Tianjin Medical University, Tianjin 300192, China

NI Hong-yan Department of Radiology, Tianjin First Central Hospital, Tianjin Medical Imaging Institute, Tianjin 300192, China

SHEN Wen Department of Radiology, Tianjin First Central Hospital, Tianjin Medical Imaging Institute, Tianjin 300192, China

YIN Jian-zhong* Department of Radiology, Tianjin First Central Hospital, Tianjin Medical Imaging Institute, Tianjin 300192, China

ZHANG Shun Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

ZHU Wen-zhen Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

*Correspondence to: Yin JZ, E-mail: yin3000@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This study was supported by National "Twelfth Five-Year" Program of Science & Technology Support No. 2011BAI08B10 Tianjin Science and Technology Support Project No. 15ZCZDSY00520 Tianjin Bureau of Public Health No. 13KG107
Received  2016-08-08
Accepted  2016-09-23
DOI: 10.12015/issn.1674-8034.2016.10.003
DOI:10.12015/issn.1674-8034.2016.10.003.

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