Share：
Share this content in WeChat
X
[Chinese][PDF]80078
• Clinical Article •
Study of relevant parameters of diffusion tensor imaging in the hippocampus of normal middle-aged group
ZHAO Xia  WANG Jian-fei  JU Wen-ping  FAN Zi-jian  LIANG Jie  WANG Xian-liang 

DOI:10.12015/issn.1674-8034.2016.10.005.


[Abstract] Objective: To discuss the change of the brain metabolites on the bilateral hippocampus of different age groups and different parts in normal Chinese middle-aged group by using Diffusion Tensor Imaging (DTI), to provide the reference for early clinical diagnosis and treatment of hippocampal-related diseases.Materials and Methods: From community healthy volunteers, we selected 276 according to the standards, who were divided into three groups according to age, A group: prime period, 41 to 48 years, 90 cases; B group: steady period, 49 to 55 years, 93 cases; C group: adjustment period, 56 to 65 years, 93 cases. All subjects underwent routine conventional MRI and bilateral hippocampal DTI examination. The parameters ADC, FA values were measured. To analyse the differences of the parameters between different genders, sides, groups and parts, and discuss the correlation between parameters and age.Results: There was no statistically significant difference of ADC and FA values of the hippocampus between different sides and genders (P>0.05). The values had statistically significant difference among groups (P<0.05). The ADC value in group A and B was lower than group C (P<0.05), the FA value in group A and B was higher than group C (P<0.05), the FA value had statistically significant difference in the different parts of hippocampal (P<0.05), the FA value in A, B and C group on hippocampal head was higher than on body and tail. The FA values were negatively correlated with age (r=-0.813, P<0.05), the ADC values were positively correlated with age (r=0.113, P<0.05).Conclusion: DTI can help to understand the changes of microenvironment of the hippocampal in normal Chinese middle-aged people, to provide clinical basis for early diagnosis and treatment of the diseases associated with hippocampus.
[Keywords] Normal middle-aged people；Hippocampus；Magnetic resonance imaging；Diffusion tensor imaging

ZHAO Xia Department of Medical Imaging, the central hospital of Qingdao, Qingdao 266042, China

WANG Jian-fei Department of Medical Imaging, the People’s Hospital of Weifang, Weifang 261041, China

JU Wen-ping Department of Medical Imaging of Weifang Medical University, Weifang 261053, China

FAN Zi-jian Department of Medical Imaging of Weifang Medical University, Weifang 261053, China

LIANG Jie Department of Medical Imaging of Weifang Medical University, Weifang 261053, China

WANG Xian-liang* Department of Medical Imaging, the People’s Hospital of Weifang, Weifang 261041, China

*Correspondence to: Wang XL, E-mail: wangxianliang2011@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Natural Science Foundation of Shandong Province No. ZR2009CM115
Received  2016-08-17
Accepted  2016-09-23
DOI: 10.12015/issn.1674-8034.2016.10.005
DOI:10.12015/issn.1674-8034.2016.10.005.

[1]
Wieshmann UC, Symms MR, Parker GJ, et al. Diffusion tensor imaging demonstrates deviation of fibres in normal appearing white matter adjacent to a brain tumour. Neurol Neurosurg Psychiatry, 2000, 68(4): 501-503.
[2]
王东东，姜春晖，王俭.轻度认知障碍磁共振扩散张量成像研究的Meta分析.磁共振成像, 2016, 7(2): 81-89.
[3]
贾策，张泉，冯凯琳.海马硬化的扩散张量成像参数值变化初步研究.武警医学院学报, 2009, 18(4): 304- 307.
[4]
Macmaster FP, Mirza Y, Szeszko PR, et al. Amygdala and hippocampal volumes in familial early onset major depressive disorder. Biol Psychiatry, 2008, 63(4): 385-390.
[5]
Fraser MA, Shaw ME, Cherbuin N. A systematic review and meta-analysis of longitudinal hippocampal atrophy in healthy human ageing. Neuroimage, 2015, 5(112): 364-374.
[6]
龚启勇，吕粟.功能磁共振成像临床应用及进展.磁共振成像, 2014, 5(增刊1): 68-72.
[7]
罗一烽，曹志宏，王冬青,等.测量正常成年人海马各部的MR T2值.中国医学影像技术, 2013, 29(1): 20- 23.
[8]
Zhu D, Zhang T, Jiang X, et al. Fusing DTI and fMRI data: a survey of methods and applications. Neuro Image, 2014, 102(1): 184-191.
[9]
Raz N, Guning-Dixon F, Head D, et al. Aging,sexual dimorphism, and hemispheric asymmetry of the cerebrale cortex:replieability of regional differences in volume. Jneuxobiol Aging, 2004, 25(3): 377-396.
[10]
Toshiyuki W, Akihiko S, Ichiro A, et al. Hippocampal metabolites and memory performances in patients with amnestic mild cognitive impairment and Alzheimer's disease. Neurobiology of Learning and Memory, 2012, 97(3): 289-293.
[11]
张泉，张云亭，张敬,等.颞叶癫痫患者海马不同节段MR扩散张量成像研究.中国医学影像技术, 2008, 23(7): 979-981.
[12]
Paxton JL, Bareh DM, Racine CA, et al.Cognitive control, goalmaintenance, and Prefrontal function in healthyaging. Cereb J Cortex, 2008, 18(5): 1010-1028.
[13]
郝敬军，庄伟雄，文海忠,等.健康成年人海马磁共振波谱与扩散加权成像研究.中国医学创新, 2014, 11(12): 72-74.
[14]
倪建明，张追阳，张威江.正常脑老化过程中脑组织弥散各向异性的变化规律研究.中国医学计算机成像杂志.2013, 19(4): 307-311.
[15]
Minati L, Grisoli M, Buzzone MG. MRSPeetroseoPy, funetionalMRI, and diffusion-tensor imaging in the aging brain:a conceptua lreview. J Geriatr Psychiatry Neurol, 2007, 20(1): 3-21.

PREV The study of carotid plaque characteristic of the low risk and high risk of acute ischemic stroke based on essen stroke risk score system
NEXT Chordoid glioma in the third ventricle: image findings and differential diagnosis: a report of three cases and review of the literature
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn