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• Clinical Article •
Study of relevant parameters of diffusion tensor imaging in the hippocampus of normal middle-aged group
ZHAO Xia  WANG Jian-fei  JU Wen-ping  FAN Zi-jian  LIANG Jie  WANG Xian-liang 

DOI:10.12015/issn.1674-8034.2016.10.005.


[Abstract] Objective: To discuss the change of the brain metabolites on the bilateral hippocampus of different age groups and different parts in normal Chinese middle-aged group by using Diffusion Tensor Imaging (DTI), to provide the reference for early clinical diagnosis and treatment of hippocampal-related diseases.Materials and Methods: From community healthy volunteers, we selected 276 according to the standards, who were divided into three groups according to age, A group: prime period, 41 to 48 years, 90 cases; B group: steady period, 49 to 55 years, 93 cases; C group: adjustment period, 56 to 65 years, 93 cases. All subjects underwent routine conventional MRI and bilateral hippocampal DTI examination. The parameters ADC, FA values were measured. To analyse the differences of the parameters between different genders, sides, groups and parts, and discuss the correlation between parameters and age.Results: There was no statistically significant difference of ADC and FA values of the hippocampus between different sides and genders (P>0.05). The values had statistically significant difference among groups (P<0.05). The ADC value in group A and B was lower than group C (P<0.05), the FA value in group A and B was higher than group C (P<0.05), the FA value had statistically significant difference in the different parts of hippocampal (P<0.05), the FA value in A, B and C group on hippocampal head was higher than on body and tail. The FA values were negatively correlated with age (r=-0.813, P<0.05), the ADC values were positively correlated with age (r=0.113, P<0.05).Conclusion: DTI can help to understand the changes of microenvironment of the hippocampal in normal Chinese middle-aged people, to provide clinical basis for early diagnosis and treatment of the diseases associated with hippocampus.
[Keywords] Normal middle-aged people；Hippocampus；Magnetic resonance imaging；Diffusion tensor imaging

ZHAO Xia Department of Medical Imaging, the central hospital of Qingdao, Qingdao 266042, China

WANG Jian-fei Department of Medical Imaging, the People’s Hospital of Weifang, Weifang 261041, China

JU Wen-ping Department of Medical Imaging of Weifang Medical University, Weifang 261053, China

FAN Zi-jian Department of Medical Imaging of Weifang Medical University, Weifang 261053, China

LIANG Jie Department of Medical Imaging of Weifang Medical University, Weifang 261053, China

WANG Xian-liang* Department of Medical Imaging, the People’s Hospital of Weifang, Weifang 261041, China

*Correspondence to: Wang XL, E-mail: wangxianliang2011@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Natural Science Foundation of Shandong Province No. ZR2009CM115
Received  2016-08-17
Accepted  2016-09-23
DOI: 10.12015/issn.1674-8034.2016.10.005
DOI:10.12015/issn.1674-8034.2016.10.005.

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