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• Clinical Article •
Chordoid glioma in the third ventricle: image findings and differential diagnosis: a report of three cases and review of the literature
WANG Wen-sheng  FANG Jin  ZHOU Quan  CHEN Yan-ping  CHENG Li-na  WU Jing  HUANG Ze-chun 

DOI:10.12015/issn.1674-8034.2016.10.006.


[Abstract] Objective: To summarize the CT and MRI findings and differential diagnosis of chordoid glioma in the third ventricle and to explore the diagnostic value of imaging examination.Materials and Methods: Three patients (two males and one females; range, 7-34 years) with chordoid glioma in the third ventricle confirmed by biopsy pathology were enrolled. The symptoms, imaging findings and pathology were retrospectively analyzed, and then a review of the literature was performed.Results: The symptoms were usually obstructive hydrocephalus, progressive headache, neuroendocrine symptoms. All the three tumors located in the third ventricle. The tumor usually represented as a large, well-circumscribed ovoid and hypodense lesion on CT. No cystic or necrotic changes were found. Only one case had peripheral calcification, as hyperdense on CT. On MRI, the lesions all showed homogeneous hypointensity on T1-weighted image and hyperintensity on T2-weighted image. Two cases showed heterogenously enhancement, while the other one showed homogeneously enhancement. Microscopically, the tumor cells arranged in clusters or scattered in a mucinous background. Tumor cell nucleus were round, oval or offset, chromatin were granulated or nubby, the nuclei were small and hyperchromatic, nuclear fission were rare. Necrosis was not identified, new blood vessels showed proliferation. Immunohistochemically, tumor cells were stained positively for GFAP and vimentin.Conclusion: There are several characteristic CT and MRI findings of chordoid glioma in the third ventricle. The diagnosis can be made when combining image findings with clinical findings. The final diagnosis should be confirmed by histopathology and immunohistochemical staining.
[Keywords] Chordoid glioma；Third ventricle；Magnetic resonance imaging；Tomography, X-ray computed

WANG Wen-sheng Department of Imaging Center, Guangdong 999 Brain Hospital, Guangzhou 510510, China

FANG Jin Medical Imaging Center, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China

ZHOU Quan* Medical Imaging Center, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China

CHEN Yan-ping Medical Imaging Center, Nanfang Hospital Affiliated Southern Medical University, GuangZhou 510515, China

CHENG Li-na Department of Imaging Center, Guangdong 999 Brain Hospital, Guangzhou 510510, China

WU Jing Department of Imaging Center, Guangdong 999 Brain Hospital, Guangzhou 510510, China

HUANG Ze-chun Department of Imaging Center, Guangdong 999 Brain Hospital, Guangzhou 510510, China

*Correspondence to: Zhou Q, E-mail: tzq@jnu.edu.cn

Conflicts of interest   None.

Received  2016-06-17
Accepted  2016-09-06
DOI: 10.12015/issn.1674-8034.2016.10.006
DOI:10.12015/issn.1674-8034.2016.10.006.

[1]
Wanschitz J, Schmidbauer M, Maier H, et al. Suprasellar meningioma with expression of glial fibrillary acidic protein: a peculiar variant. Acta Neuropathol, 1995, 90(5): 539-544.
[2]
Brat DJ, Scheithauer BW, Staugaitis SM, et al. Third ventricular chordoid glioma: a distinct clinicopathologic entity. J Neuropathol Exp Neurol, 1998, 57(3): 283-290.
[3]
Louis DN, Perry A, Reifenberger G, et al. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol, 2016, 131(6): 803-820.
[4]
Castellano-Sanchez AA, Schemankewitz E, Mazewski C, et al. Pediatric chordoid glioma with chondroid metaplasia. Pediatr Dev Pathol, 2001, 4(6): 564-567.
[5]
Goyal R, Vashishta RK, Singhi S, et al. Extraventricular unusual glioma in a child with extensive myxoid change resembling chordoid glioma. J Clin Pathol, 2007, 60(11): 1294-1295.
[6]
Jain D, Sharma MC, Sarkar C, et al. Chordoid glioma: report of two rare examples with unusual features. Acta Neurochir (Wien), 2008,150(3): 295-300.
[7]
Bongetta D, Risso A, Morbini P, et al. Chordoid glioma: a rare radiologically, histologically, and clinically mystifying lesion. World Journal of Surgical Oncology, 2015, 13(1): 188.
[8]
Buccoliero AM, Caldarella A, Gallina P, et al. Chordoid glioma: clinicopathologic profile and differential diagnosis of an uncommon tumor. Arch Pathol Lab Med, 2004, 128(11): 141-145.
[9]
Sato K, Kubota T, Ishida M, et al. Immunohisochemical and ultrastructural study of chordoid glioma of the third ventricle: its anycytic differentiation. Acta Neuropathol, 2003, 106(2): 176-180.
[10]
Leeds NE, Lang FF, Ribalta T, et al. Origin of chordoid glioma of the third ventricle. Arch Pathol Lab Med, 2006, 130(4): 460-464.
[11]
Suh YL, Kim NR, Kim JH, et al. Suprasellar chordoid glioma combined with Rathke's cleft cyst. Pathol Int, 2003, 53(11):780-785.
[12]
汪文胜.第三脑室脊索瘤样胶质瘤一例.中华放射学杂志, 2007,41(8): 892-893.
[13]
Romero-Rojas AE, Díaz-Pérez JA, Ariza-Serrano LM. CD99 is expressed in chordoid glioma and suggests ependymal origin. Virchows Arch, 2012, 460(1): 119-122.
[14]
Ni HC, Piao YS, Lu DH, et al. Chordoid glioma of the third ventricle: four cases including one case with papillary features. Neuropathology, 2013, 33(2): 134-139.
[15]
Takei H, Bhattacharjee MB, Adesina AM. Chordoid glioma of the third ventricle: report of a case with cytologic features and utility during intraoperative consultation. Acta Cytol, 2006, 50(6): 691-696.
[16]
Kobayashi T, Tsugawa T, Hashizume C, et al. Therapeutic approach to chordoid glioma of the third ventricle. Neurol Med Chir (Tokyo), 2013, 53(4): 249-255.
[17]
赵飞行，汪春年，石群立,等.第三脑室脊索样胶质瘤3例报道及文献复习.临床与实验病理学杂志, 2008, 24(4): 399-406.
[18]
Grand S, Pasquier B, Gay E, et al. Chordoid glioma of the third ventricle: CT and MRI, including perfusion data. Neuroradiology, 2002, 44(10): 842-846.
[19]
Restrepo R, Howard LH, Robinson MJ. Chordoid glioma: A novel tumor of the third ventricle. Ann Diagn Pathol, 2000, 4(6): 373-378.
[20]
程婉滢，罗麟，马军.第三脑室脊索样脑膜瘤1例.磁共振成像,2011, 2(1): 75-76.
[21]
宋茜，齐悦彤，李莹.第三脑室脊索样胶质瘤1例.磁共振成像, 2011, 2(2): 157-158.
[22]
史红媛，田迎，史玉振,等.第三脑室脊索样胶质瘤的MRI表现.中华医学杂志, 2013, 93(5): 373-375.

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