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Applications of blood oxygen level dependent-functional magnetic resonance imaging in patients with moyamoya disease
WANG Yi-tuo  LI Gong-jie  YANG Zheng 

DOI:10.12015/issn.1674-8034.2016.10.013.


[Abstract] The cerebral hypoperfusion level may vary with the stages of moyamoya disease (MMD). A reasonable therapeutic strategy should be developed according to the perfusion status of each patient. CT perfusion imaging and MR perfusion imaging are commonly used to assess perfusion status in patients with MMD. Unfortunately, the risk of anaphylaxis to contrast media will increase as well. In recent years, the blood oxygenation level-dependent functional MR imaging (BOLD-fMRI) has been increasingly used to evaluate perfusion status and neuronal plasticity in a non-invasive way. Here, we review the progress of BOLD-fMRI in terms of cerebrovascular reactivity (CVR) and non-invasive assessment of the delayed blood flow information and neuronal plasticity in patients with MMD in order to provide a new perspective on the time of operation and prognosis assessment.
[Keywords] Moyamoya disease；Blood oxygenation level-dependent；Magnetic resonance imaging, functional；Cerebrovascular reactivity

WANG Yi-tuo Cognitive and Mental Health Research Center, Beijing Institute of Basic Medical Sciences, Beijing 100850, China; Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China

LI Gong-jie Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China

YANG Zheng* Cognitive and Mental Health Research Center, Beijing Institute of Basic Medical Sciences, Beijing 100850, China

*Correspondence to: Yang Z, E-mail: yangz236@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Youth Project Beijing Municipal Natural Science Foundation No. 7144231 Capital Characteristic Clinic Project No. Z141107002514171
Received  2016-08-02
Accepted  2016-09-23
DOI: 10.12015/issn.1674-8034.2016.10.013
DOI:10.12015/issn.1674-8034.2016.10.013.

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