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• Clinical Article •
The repeatability of diffusion kurtosis imaging on the brain tissue in healthy adults
BAO Dao-liang  ZHANG Mei-fang  SU Li-qing  XIAO You-ping  CAO Xi-sheng  YAO Yi-qi  CHEN Yun-bin 

DOI:10.12015/issn.1674-8034.2016.11.002.


[Abstract] Objective: To study the reproducibility of diffusion kurtosis imaging (DKI) on the brain tissue in healthy adults.Materials and Methods: Twenty-six healthy volunteers aged from 31 to 66 years were enrolled into this present study. All enrolled subjects were scanned with the DKI sequence on their head and b-factors of 0, 500, 1000, 1500, and 2000 s/mm2 were applied. Two observers (experienced radiologist) independently interpreted the acquired DKI images and conducted the measurement of diffusion coefficient (MD) and diffusion kurtosis coefficient (MK). All statistical analysis were conducted on the SPSS 19.0 software, and the inter-and intra-observer consistency of diffusion coefficient (MD) and diffusion kurtosis coefficient (MK) were tested by the repeatability measurements.Results: The MD and MK of the genu and splenium of the corpus callosum, the anterior and posterior limbs of internal capsule and thalamus were measured by two observers at the different time-points respectively. As a result, the difference between the measurements conducted by the same observer at the different times (intra-observer) was not statistically significant (P>0.05), whereas the difference between the measurements between different observers (inter-observer) was also not statistically significant (P>0.05).Conclusions: The parameter measurements of DKI on the brain tissues of normal adults are repeatable and may be potentially used to reflect the changes of the micro-structures of brain tissue.
[Keywords] Diffusion kurtosis imaging；Diffusion coefficient；Diffusion kurtosis coefficient；Repeatability

BAO Dao-liang Department of Radiology, Fujian Tumor Hospital, Fuzhou 350014, China

ZHANG Mei-fang Department of Radiology, Fujian Tumor Hospital, Fuzhou 350014, China

SU Li-qing Department of Radiology, Fujian Tumor Hospital, Fuzhou 350014, China

XIAO You-ping Department of Radiology, Fujian Tumor Hospital, Fuzhou 350014, China

CAO Xi-sheng Department of Radiology, Fujian Tumor Hospital, Fuzhou 350014, China

YAO Yi-qi Department of Radiology, Fujian Tumor Hospital, Fuzhou 350014, China

CHEN Yun-bin* Department of Radiology, Fujian Tumor Hospital, Fuzhou 350014, China

*Correspondence to: Chen YB, E-mail: yunbinchen@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This study is partly supported by the Social Development Guidance Project of Fujian Province, the National Clinical Key Specialty Construction Program and the Key Clinical Specialty Discipline Construction Program of Fujian No. 2014Y0013
Received  2016-07-26
Accepted  2016-10-08
DOI: 10.12015/issn.1674-8034.2016.11.002
DOI:10.12015/issn.1674-8034.2016.11.002.

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