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• Clinical Article •
Value of dynamic contrast-enhancement MRI for the prediction of chemoradiotheray efficacy in nasopharyngeal carcinoma
Guo Xiao-han  TIAN Xing-cang  LI Wen-ling  MU Li-sha  SUN Kai  PU Yan-jun  ZHU Li 

DOI:10.12015/issn.1674-8034.2016.11.008.


[Abstract] Objective: To prospectively evaluate the efficacy of pre-treatment DCE-MRI for treatment response to chemoradiotherapy (CRT) of nasopharyngeal carcinoma.Materials and Methods: Thirty-seven patients with confirmed NPC by biopsy pathology underwent MRI plain scan and DCE-MRI before concurrent chemoradiation. Calculate the mean, maximum and minimum area of the semiquantitative parameters. Reexamined those patients with MRI during treatment (receiving dose of 56 Gy) and measure the tumor regression rate respectively. Classified patients into responders and nonresponders, based on RECIST 1.1. Spearman correlation analysis was examed between both pre-treatment mean, hign enhancement and low enhancement area of the semiquantitative parameters and regression rate,respectively. ROC analyses were used to determine the best model to discriminate responders from nonresponders.Results: Among all the parameters, there was a significant negative correlation between tumor regression rate and maximum TTP. When use TTP<65.53s as a cutoff, we observed AUC=0.843 with sensitivity and specificity is 100% and 43.33% respectively in differentiating CR (n=7) from others (n=30).Conclusions: Semiquantitative parameters derive from DCE-MRI before treatment were capable to predict early treatment efficacy during concurrent chemoradiation in nasopharyngeal carcinoma, which has potential to be helpful in individualized therapy.
[Keywords] Nasopharyngeal neoplasms；Magnetic resonance imaging；Chemoradiotherapy；Program evaluation

Guo Xiao-han Tangdu Hospital of The Forth Military Medical University, Xi’an 710038, China

TIAN Xing-cang Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China

LI Wen-ling Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China

MU Li-sha Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China

SUN Kai Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China

PU Yan-jun Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China

ZHU Li* Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China

*Correspondence to: Zhu L, E-mail: zhuli72@163.com

Conflicts of interest   None.

Received  2016-08-29
Accepted  2016-10-16
DOI: 10.12015/issn.1674-8034.2016.11.008
DOI:10.12015/issn.1674-8034.2016.11.008.

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