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• Original Article •
Effect of gadolinium on vertebral fat fraction content using IDEAL-IQ technique
LIN Yuan  ZHA Yun-fei  XING Dong  HU Lei  WANG Jiao  ZENG Fei-fei  LU Xue-song 

DOI:10.12015/issn.1674-8034.2016.11.012.


[Abstract] Objective: This study evaluates the robustness of a magnetic resonance (MR) fat quantification method to changes in R2* caused by an intravenous infusion of gadolinium.Materials and Methods: The R2* and fat fraction content (FF) were measured in vertebral marrow in eight New Zealand white rabbits using an investigational sequence (IDEAL IQ) provided by the MR scanner vendor. Measurements were made once before and twice after Gd-BOPTA infusion (5 min, 30 min). Then HE stain was performed for calculating vertebral fat content (FCHIS), Prussian blue stain was performed for showing iron in vertebral.Results: Vertebral marrow FF measurements revealed no significant systematic bias between the three measurements (P>0.05 for all). Good agreement (95% confidence interval) of FF measurements were demonstrated between FF0 min and FF5 min (0.90, 1.10) and FF0 min and FF30 min (0.94, 1.07). A significant positive correlation is found between FF0 min and FCHIS (r=0.813, P<0.05). R2* increased after administration of gadolinium.Conclusion: Although under the impact of an increased R2* in vertebral marrow post-contrast, the investigational sequence can still obtain accurate and stable fat fraction content. the IDEAL IQ method of fat quantification is robust to changes in R2*.
[Keywords] Bone marrow；Fats；Magnetic resonance imaging；Contrast media

LIN Yuan Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

ZHA Yun-fei* Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis & Treatment, Wuhan 430060, China

XING Dong Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

HU Lei Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

WANG Jiao Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

ZENG Fei-fei Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

LU Xue-song Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis & Treatment, Wuhan 430060, China; Department of Biological Engineering, School of Biomedical Engineering, South-Central University for Nationalities, Wuhan 430060, China

*Correspondence to: Zha YF, E-mail: zhayunfei@hotmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This thesis is sponsored by the Opening Foundation of Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis & Treatment No. PJS140011511 Scientific Research Funding Project of Hubei Provincial Department of Health No. JX6B68
Received  2016-09-26
Accepted  2016-10-20
DOI: 10.12015/issn.1674-8034.2016.11.012
DOI:10.12015/issn.1674-8034.2016.11.012.

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