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• Technical Article •
A method of TMS coil positioning based on functional and structural MRI
ZHANG Hui  HU Rui-ping  WANG Meng-xing  ZHANG Ji-lei  LU Hai-feng  DU Xiao-xia 

DOI:10.12015/issn.1674-8034.2016.11.013.


[Abstract] Transcranial magnetic stimulation (TMS) has been widely applied to clinical therapy, the accuracy of coil positioning in brain functional areas is crucial for TMS effects. In recent years, neuronavigation-guided TMS has greatly improved the accuracy, but require a variety of equipment, which cannot be deployed in every circumstance, such as MRI scanning. And navigation system is expensive, some TMS without navigation, then how to position the TMS coil is a problem. In this paper we provide a method of TMS coil positioning based on magnetic resonance imaging (MRI). Here, using repetitive TMS (rTMS) treatment of aphasia as an example, collecting high-resolution T1WI and functional MRI data of the speech-language tasks. The data were analyzed using SPM8, and the 3D brain activation map was built with MRIcron software, then marking the coordinate of rTMS stimulation site and another coordinate of the landmark on the scalp. Finally, the rTMS stimulation site can be determined in an individual head according to the marks and coordinates relations. The procedure to determine TMS stimulation site is carried out on individual's own structure, with advantages of high accuracy, simple operation, easy to implement and cost savings. This method can be applied flexibly.
[Keywords] Transcranial magnetic stimulation；Coil positioning；Brain functional areas；Magnetic resonance imaging

ZHANG Hui Shanghai Key Laboratory of Magnetic Resonance & Department of Physics, East China Normal University, Shanghai 200062, China

HU Rui-ping Department of Rehabilitation Medicine, Hua Shan Hospital, Fudan University, Shanghai 200040, China

WANG Meng-xing Shanghai Key Laboratory of Magnetic Resonance & Department of Physics, East China Normal University, Shanghai 200062, China

ZHANG Ji-lei Shanghai Key Laboratory of Magnetic Resonance & Department of Physics, East China Normal University, Shanghai 200062, China

LU Hai-feng Shanghai Key Laboratory of Magnetic Resonance & Department of Physics, East China Normal University, Shanghai 200062, China

DU Xiao-xia* Shanghai Key Laboratory of Magnetic Resonance & Department of Physics, East China Normal University, Shanghai 200062, China

*Correspondence to: Du XX, E-mail: xxdu@phy.ecnu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article research work obtained the National Natural Sciences Foundation project subsidization No. 81201082, 81571658
Received  2016-09-22
Accepted  2016-10-17
DOI: 10.12015/issn.1674-8034.2016.11.013
DOI:10.12015/issn.1674-8034.2016.11.013.

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