Share：
Share this content in WeChat
X
[Chinese][PDF]89597
• Clinical Article •
Measurement of fat content in vertebral body by magnetic resonance water fat separation
CHANG Fei-xia  HUANG Gang  FAN Dun-hui  XU Xiang-jiu  MA Xiao-mei  WANG Ping  SHEN Wen-yi 

DOI:10.12015/issn.1674-8034.2016.12.003.


[Abstract] Objective: Taking DXA as a reference standard, the use of magnetic resonance (NMR) water and fat separation imaging technology (Dixon) can measure the fat signal intensity and calculate the fat fraction (FF) in order to evaluate the application value of vertebral bone mineral density.Materials and Methods: Thirty-six cases of lumbar vertebral body(L1-L4) (144 vertebral body) in which the patients checked in Gansu Provincial People's Hospital were retrospectively collected. All patients who were performed DXA and MR examination of lumbar spine were divided into normal group(T≥-1.0 SD), osteopenia group (-1.0--2.5SD) and osteoporosis group (≤-2.5SD), according to DXA results and the diagnostic criteria of WHO; At the same time, we measured and calculated the waist 1-4 of the vertebral body signal intensity (T2 fat alike) and fat fraction (FF), Marrow fat formula of FF MRI: FF=[Mfat/(Mfat+Mwater)]×100%(Mwater, Mfat respectively refers to water and lipid like ROI total pixel signal strength value) to evaluate the magnetic resonance (NMR) water and fat separation imaging techniques to predict the ability of osteoporosis.Results: According to DXA results, in a total of 144 vertebral bodies involved 36 patients, 58 subjects were in normal group, 28 subjects were in osteopenia group and 58 subjects were in osteoporosis group. The Fat signal intensity of the three groups (normal group, osteopenia group and osteoporosis group) were 100.2±20.1, 156.1±56.3, 211.9±84.6, and the fat fraction (FF) were (31.1±6.2)%, (53.3±7.6)%, (77.8±7.2)%, respectively. Among osteoporosis group and osteopenia group and normal group, lumbar fat T2 signal intensity and fat fractions were statistically different (P<0.01). When the fat signal intensity negatively correlated with DXA, the correlation coefficient was r=-0.64, P<0.01; when the fat fraction (FF) negatively correlated with DXA, the correlation coefficient was r=-0.93, P<0.01.Conclusion: Lumbar signal strength and fat fraction through magnetic resonance (NMR) water and fat separation imaging by ROI can reflect the change of the vertebral body fat content in patients with osteoporosis, and is of high value in clinical application. With T value of DXA as the standard, the possibility of having BMD screening for osteoporosis correlation during Dixon check is comparatively high. As a result, it has a certain application prospect to evaluate the bone mineral density of the lumbar spine by simply measuring the fat signal intensity and calculating the fat fraction of ROI.
[Keywords] Magnetic resonance imaging；Water-fat separation technology；Vertebral；Fat fraction；Osteoporosis

CHANG Fei-xia Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China; Dunhuang Hospital of Gansu province, Dunhuang 736200, China

HUANG Gang* Department of Radiology, Gansu Provincial People’s Hospital, Lanzhou 730000, China

FAN Dun-hui Dunhuang Hospital of Gansu province, Dunhuang 736200, China

XU Xiang-jiu Department of Radiology, Gansu Provincial People’s Hospital, Lanzhou 730000, China

MA Xiao-mei Department of Radiology, Gansu Provincial People’s Hospital, Lanzhou 730000, China

WANG Ping Department of Radiology, Gansu Provincial People’s Hospital, Lanzhou 730000, China

SHEN Wen-yi Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

*Correspondence to:Huang G, E-mail: keen0999@163.com

Conflicts of interest   None.

Received  2016-08-08
Accepted  2016-09-20
DOI: 10.12015/issn.1674-8034.2016.12.003
DOI:10.12015/issn.1674-8034.2016.12.003.

[1]
朴俊红，庞莲萍，刘忠厚,等.中国人口状况及原发性骨质疏松症诊断标准和发生率.中国骨质疏松杂志, 2002, 8(1): 1-7.
[2]
中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊治指南(2011年).中华骨质疏松和骨矿盐疾病杂志, 2011, 4(1): 2-17.
[3]
Griffith JF, Yeung DK, Antonio GE, et al. Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: dynamic contrast -enhanced MR imaging and MR spectroscopy. Radiology, 2005, 236(3): 945-951.
[4]
Youn Y, Lee HY, Kim JK, et al. Correlation between vertebral marrow fat fraction measured using Dixon quantitative chemical shift MRI and BMD value on dual-energy X-ray absorptiometry. Korean Soc Magn Reson Med, 2012, 16(1): 16-24.
[5]
阳宁静，宋彬，唐鹤菡,等. 1H-MRS和MR双回波技术活体半定量评价酒精性与非酒精性脂肪肝大鼠模型.磁共振成像, 2010, 1(3): 208-213.
[6]
Hu HH, Kim HW, Nayak KS, et al. Comparison of fat-water MRI and single-voxel MRS in the assessment of hepatic and pancreatic fat fractions in humans. Obesity (Silver spring Md), 2010, 18(4): 841.
[7]
Roca M, Mota J, Alfonso P, et al. S-MRI score: A simple method for assessing bone marrow involvement in Gaucher disease. Eur J Radiol, 2007, 62(1): 132.
[8]
林楚岚，江桂华，陈楚庄,等.基于mDixon方法快速量化非酒精性脂肪肝脂肪含量的研究.中山大学学报, 2015, 5(3): 465-471.
[9]
秦莹，尚家芸，唐成志,等. DXA仪测量骨密度的质量控制及效果评价.中华骨质疏松和骨矿盐疾病杂志, 2014, 7(1): 55-61.
[10]
Guglielmi G, Van Kuijk C, Li J, et al. Influence of anthropometric parameters and bone size on bone mineral density using volumetric quantitative computed tomographyand dual X-ray absorptiometry at the hip. Acta Radiologica, 2006, 47(6): 574-580.
[11]
孔令懿，马毅民，王倩倩,等.定量CT测量髋关节骨密度的重复性与DXA测量的一致性.中华骨质疏松和骨矿盐疾病杂志, 2013, 6(4): 334-339.
[12]
刘智，蔡跃增.氢质子磁共振波谱在骨质疏松诊断中的应用价值.中国骨质疏松杂志, 2014, 20(12): 1417-1420.
[13]
雷立存，何丽，刘斋,等.磁共振化学位移成像对骨质疏松的诊断价值.中国临床医学影像杂志, 2014, 25(9): 648-651.
[14]
雷立存，任庆云.磁共振化学位移成像评估椎体骨髓脂肪含量的应用.影像诊断与介入放射学, 2015, 2(2): 142-146.
[15]
徐铮，李冠武，顾昊,等. 2点Dixon技术评价鼠骨质疏松模型骨髓脂肪:与病理对照.中国骨质疏松杂志, 2015, 21(4): 399-402.
[16]
李冠武，常时新，田芳,等.骨髓脂肪含量预测骨质疏松性椎体骨折价值的初步应用.中国中西医结合学会医学影像专业委员会.全国第十三次中西医结合影像学术研讨会全国中西医结合影像学研究进展学习班福建省第八次中西医结合影像学术研讨会论文汇编.福州, 2014.
[17]
Justesen J, Stenderup K, Ebbesen EN, et al. Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis. Biogerontology, 2001, 2(3): 165-171.
[18]
Meunier P, Aaron J, Edouard C, et al. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue, A quantitative study of 84 iliac bone biopsies. Clin Orthop Relat Res, 1971, 80(2): 147-154.
[19]
张维成，陈志信，王和平,等.大鼠骨髓基质细胞体外成脂、成骨分化的研究.中国骨质疏松杂志, 2005, 11(1): 45-48．
[20]
Naverias O, Nardi V, Wenzed PL, et al. Bone-marrow adipocytes as negative regulators of the haematopoietic microenviroment. Nature, 2009, 460(7252): 259-263.
[21]
Hajek PC, Baker LL, Goobar JE, et al. Focal fat deposition in axial bone marrow, MR characteristics. Radiology, 1987, 162(1): 245-249.
[22]
Ojanen X, Borra RJ, Havu M, et al. Comparison of vertebral bone marrow fat assessed by 1H MRS and inphase and out-of phase MRI among family members. Osteoporos Int, 2014, 25(1): 653-662.
[23]
郭启勇，石喻.磁共振成像在肝病的应用及进展.磁共振成像, 2014, 5(S1): 10-14.
[24]
李瑾，尹大庆，朱玲,等.正常人腰椎正位骨密度测量结果分析.中国骨质疏松杂志, 2002, 8(2): 121-122.
[25]
肖越勇，张金山，华伯勋,等.定量CT骨密度测量预测椎体压缩骨折的实验研究.中国医学影像技术, 2002, 18(7): 625-627.
[26]
陈瑶，周蕾，李冠武,等. MRI水-脂成像评价原发性骨质疏松模型鼠骨髓脂肪含量的价值.临床放射学杂志, 2014, 33(10): 1604-1608.
[27]
余卫，秦明伟，张燕,等.腰椎退行性骨关节病对骨密度测定的影响.中华放射学杂志, 2002, 36(3): 245-248.
[28]
Schneider DL, Bettencourt R, Barrett-Connor E. The clinical utility of spine bone density in elderly women. J Clin Densitom, 2006, 9(3): 255-260.

PREV The effect of global signal correction on the functional connectivity of resting brain networks
NEXT Value of liver T2* and SF to predict myocardial iron concentration patients with thalassemia
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn