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• Clinical Article •
Correlation research of the ADC value of MR diffusion weighted imaging in differential differentiation of rectal tumor, perineural invasion and peritumor-intravascular cancer emboli
LV Qian-ting  CHEN Yong  LI Shan-mei  XI Yan-yan  ZHU Kai  MA Wen-dong  CHEN Yu-xin  GAO Zhi-ling 

DOI:10.12015/issn.1674-8034.2016.12.005.


[Abstract] Objective: To observe the correlation of the apparent diffusion coefficient (ADC) value, exponential apparent diffusion coefficient (eADC) value of MR diffusion weighted imaging (DWI) in differential differentiation of rectal tumor with different b values, and the correlation of ADC value and perineural invasion, peritumor-intravascular cancer emboli in tumor.Materials and Methods: Thirty-two patients with operable rectal cancer underwent preoperative MR imaging with single-shot echo plannar imaging (EPI) diffusion-weighted sequences (b=50, 500, 1000 s/mm2). Measure and compare the apparent diffusion coefficient (ADC) value and exponential apparent diffusion coefficient (eADC) value of MR diffusion weighted imaging (DWI) in rectal wall and differential differentiation of rectal tumor, and the correlation of ADC value and perineural invasion, peritumor-intravascular cancer emboli in tumor. All of them were compared with pathologicstaging.Results: The rectal carcinomas were slightly high signal or high signal on DWI. When b value is 50, 500, 1000 s/mm2, the mean ADC value of tumor is (2.732±0.805)×10-3 mm2/s, (1.226±0.195)×10-3 mm2/s, (1.042±0.228)×10-3 mm2/s, the mean eADC value of tumor is (0.097±0.058) mm2/s, (0.304±0.055) mm2/s, (0.363±0.070) mm2/s, respectively. With each b value, the mean ADC value of tumor increases following the ascending of differentiated degree of rectal carcinoma, and the mean eADC value decreases. When b value is 500, 1000 s/mm2, the difference is statistically significant (b=500 s/mm2, P= 0.03, F= 4.123; b=1000 s/mm2, P=0.001, F=10.797). In most of group, the mean ADC value of peritumor-intravascular cancer emboli and perineural invasion are lower than the negative, and the difference is statistically significant in b=500 s/mm2 of MR diffusion weighted imaging. And analyze the spearson correlation coefficient of differential differentiation of rectal tumor in different b values.The ADC value of tumor and differentiation have positive correlation (rs=0.742, P<0.05), and have negative correlation with eADC values (rs=-0.630, P<0.05) with b value of 1000 s/mm2. ADC values have the better diagnostic efficiency for diagnosis of rectal adenocarcinoma with b value of 1000 s/mm2.Conclusion: The diffusion-weighted imaging is a rapid and feasible method in detecting rectal cancer. The correlation can be pointed out between ADC and pathological classification of each tumor, and the relationship of the ADC value and perineural invasion, peritumor-intravascular cancer emboli in tumor. Therefore, the ADC value can respresent an important imaging biomarker for assessing the response to radiochemotherapy and the prognose of the tumor.
[Keywords] Rectal neoplasms；Diffusion magnetic resonance imaging；Magnetic resonance imaging；Apparent diffusion coefficient；Peritumor-intravascular cancer emboli

LV Qian-ting Ningxia Medical University, Yinchuan 750004, China

CHEN Yong General Hospital of Ningxia Medical University, Yinchuan 750004, China

LI Shan-mei Ningxia Medical University, Yinchuan 750004, China

XI Yan-yan General Hospital of Ningxia Medical University, Yinchuan 750004, China

ZHU Kai General Hospital of Ningxia Medical University, Yinchuan 750004, China

MA Wen-dong General Hospital of Ningxia Medical University, Yinchuan 750004, China

CHEN Yu-xin Guiyang Medical University, Guiyang 550004, China

GAO Zhi-ling* General Hospital of Ningxia Medical University, Yinchuan 750004, China

*Correspondence to: Gao ZL, E-mail: gzl6988@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Science and Technology Key Projects of Ningxia No. 2016KJHM63
Received  2016-09-18
Accepted  2016-11-20
DOI: 10.12015/issn.1674-8034.2016.12.005
DOI:10.12015/issn.1674-8034.2016.12.005.

[1]
Siegel R, Deepa MS, Dvm AJ. Cancer statistics, 2013. Ca A Cancer Journal for Clinicians, 2013, 63(1): 11-30.
[2]
康英杰，张皓.磁共振弥散加权成像在直肠癌检查中的价值.磁共振成像, 2015, 6(2): 155-160.
[3]
Koh DM, Padhani AR. Diffusion weighted MRI: a new functional clinical technique for tumor imaging. Br J Radiol, 2006, 79(944): 633-635.
[4]
Patterson DM, Padhani AR, Collins DJ. Technology insight: water diffusion MRI-a potential new biomarker of response to cancer therapy. Nat Cli Pract Oncol, 2008, 5(4): 220-233.
[5]
Padhani AR, Liu G, Koh DM, et al. Diffusion-weighted magnetic resonance imaging as a cancer biomarker: consensus and recommendations. Neoplasia, 2009, 11(2): 102-125.
[6]
张单霞，朱绍成，管枢,等.MR体素内不相干运动扩散加权成像对直肠腺癌T分期及分化程度的应用价值研究.磁共振成像, 2016, 7(8): 561-566.
[7]
Chavhan GB, Alsabban Z, Babyn PS. Diffusion-weighted imaging in pediatric body MR imaging: principles, technique, and emerging applications. Radio Graphics, 2014, 34(3): 73-88.
[8]
高永伟，牛广明，韩晓东. 3.0 T磁共振诊断直肠癌ADC值与肿瘤分化程度的相关性分析.中国医疗前沿, 2012, 7(6): 7-8.
[9]
亓俊霞，白人驹，于长路,等.磁共振扩散加权成像对直肠癌的显示及恶性程度评估的初步研究.实用放射学杂志, 2013, 29(3): 400-404.
[10]
廖雪芮，张修石，张红霞. MR弥散加权成像ADC值与直肠癌临床病理因素的相关性.中国肿瘤, 2016, 25(1): 76-80.
[11]
Dzik-Jurasz A, Domenig C, George M, et al. Diffusion MRI for prediction of response of rectal cancer to chemoradiation. Lancet, 2002, 360(9329): 307-308.
[12]
孙应实，唐磊，李洁,等.磁共振扩散成像与直肠癌术前放化疗病理反应性的对照研究.当代医学, 2010, 16(8): 58-63.
[13]
杜长征，王晓春，薛卫成,等.新辅助治疗在直肠癌脉管癌栓中的临床意义.中华消化外科杂志, 2010, 9(4): 265-268．

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