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• Clinical Article •
Clinical value of diffusion weighted imaging apparent diffusion coefficient and quantitative parameters of MR dynamic enhancement of cervical cancer
HE Yong-hong  LIN Qi  ZHAN Ze-juan  RUAN Cong-hua  TANG Lang-lang  CHEN Jin-yin  DENG Yan-fang  HUNG Zhen-huan 

DOI:10.12015/issn.1674-8034.2016.12.007.


[Abstract] Objective: To investigate the clinical significance of diffusion-weighted imaging apparent diffusion coefficient (ADC) values and MR dynamic contrast-enhanced quantitative parameters in cervical cancer.Materials and Methods: One hundred patients with cervical cancer and 20 healthy volunteers were performed by diffusion-weighted (with b-value of 0 s/mm2 and 800 s/mm2) and dynamic contrast-enhanced MRI scanning. (1) Measuring the ADC values: ADC map was obtained when b-value was 800 s/mm2. When three interesting points were measured in the lesions, ADCmean was served as the average value. (2) Inputting the dynamic enhanced data to the workstation: Homodynamic parameters, such as Ktrans, Kep and Ve, were obtained by the dynamic model (Tofts model) software. The comparison of the independent samples was accomplished by the t-test. Using linear regression analysis and drawing ROC curve, the effectiveness which commixed by Ktrans, Kep and ADCmean to the diagnosis of cervical cancer can be analyzed. The significant threshold was set as P<0.05.Results: The ADCmean and mean values of cervical cancer group Ktrans, Kep and Ve were respectively(0.8600±0.1608)×10-3 mm2/s, (2.6650±1.4750)/min, (4.0369±2.1073)/min and 0.4875±0.2336; But those in healthy group were (1.3495±0.1543)×10-3 mm2/s, (0.9086±0.4922)/min, (1.3689±0.5214)/min and 0.4204±0.2771. The linear regression analysis showed that P value between ADCmean and Ktrans (or ADCmean and Kep or Ktrans and Kep) was less than 0.05, which was significant statistically; That VeP value is greater than 0.05, which was no significant statistically. Furthermore the ROC curve was utilized to analyze the effectiveness of cervical cancer which commixed by Ktrans, Kep and ADCmean. When the threshold value was 0.6, the sensitivity and specific degrees of ADCmean, Ktrans and Kep were 98% and 100%, 98% and 75%, 100% and 90%, respectively.Conclusion: ADCmean and dynamic enhanced quantitative parameters (Ktrans and Kep) could be treated as the reliable markers for diagnosis of cervical cancer in the MR imaging. The combinational applications could improve the diagnostic rate.
[Keywords] Uterine cervical neoplasms；Diffusion-weighted imaging；Apparent diffusion coefficient；Dynamic enhancement；Quantitative analysis

HE Yong-hong Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

LIN Qi* Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

ZHAN Ze-juan Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

RUAN Cong-hua Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

TANG Lang-lang Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

CHEN Jin-yin Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

DENG Yan-fang Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

HUNG Zhen-huan Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

*Correspondence to: Lin Q, E-mail: 2624403530@qq.com

Conflicts of interest   None.

Received  2016-07-22
Accepted  2016-09-25
DOI: 10.12015/issn.1674-8034.2016.12.007
DOI:10.12015/issn.1674-8034.2016.12.007.

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