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Comparison of MRI signs with pathological findings in giant cell glioblastoma: A report of 9 cases
ZHANG Ling-yan  ZHANG Pei-li  ZHANG Xue-ling  ZHOU Jun-lin  DONG Chi 

DOI:10.12015/issn.1674-8034.2016.12.008.


[Abstract] Objective: To analyze the MRI features of giant cell glioblastoma.Materials and Methods: The collection of 9 cases confirmed by operation and pathology in patients with giant cell glioblastoma MRI data. The imaging findings were analyzed and correlated with pathology.Results: (1) Position: 8 tumors of 9 patients were located cerebral superficial, with temporal lobe 4 cases, parietal lobe 2 cases, occipital lobe 1 case, frontoparietal 1 case and lateral ventricles 1 case. (2) Number: single lesion in 7 cases, multiple focal lesions in 1 case. (3) The MRI performance: ① Six of 9 cases were margin clear. ② Peripheral edema 7 cases of mild, 2 cases of moderate. ③ Six cases showed homogeneously isointense or slightly hypointense on T1WI and isointense or slightly hyperintense on T2WI, 3 cases showed mixed hypointense on T1WI and hyperintense on T2WI. ④ Enhance: Six tumors enhanced homogeneously and 3 cases enhanced heterogeneously. Intralesional obvious necrosis in 3 cases, hemorrhage in 3 cases, "dural tail sign" in 1 case. (4) Pathology: ① Margin clear in 7 cases, necrosis in 3 cases, hemorrhage in 3 cases. ② Immunohistochemistry: glial fibrilary acidic protein positive, Vimentin positive, high expression of Ki-67.Conclusion: Some imaging features can be found in giant cell glioblastoma. Combining imaging features with the location of lesion, mild peripheral edema and clear edge may contribute to diagnosis.
[Keywords] Glioblastoma；Magnetic resonance imaging；Pathology, clinical

ZHANG Ling-yan Department of Medical Imaging Center, the Second Hospital of Lanzhou University, Lanzhou 730000, China

ZHANG Pei-li Department of Medical Imaging Center, the Second Hospital of Lanzhou University, Lanzhou 730000, China

ZHANG Xue-ling Department of Medical Imaging Center, the Second Hospital of Lanzhou University, Lanzhou 730000, China

ZHOU Jun-lin* Department of Medical Imaging Center, the Second Hospital of Lanzhou University, Lanzhou 730000, China

DONG Chi Department of Pathology, the Second Hospital of Lanzhou University, Lanzhou 730000, China

*Correspondence to: Zhou JL, E-mail: zjl601@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by the Scientific Research Project of Gansu Province No. GSWST2012-01
Received  2016-05-09
Accepted  2016-08-02
DOI: 10.12015/issn.1674-8034.2016.12.008
DOI:10.12015/issn.1674-8034.2016.12.008.

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