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• Clinical Article •
The preliminary study of aquaporins function with multi b-values diffusion weighted magnetic resonance imaging in the grading diagnosis of cerebral astrocytoma
DUAN Xiao-fan  ZHANG Hui  WANG Xiao-chun  TAN Yan  QIN Jiang-bo  WANG Le  ZAHNG Lei 

DOI:10.12015/issn.1674-8034.2017.01.004.


[Abstract] Objective: To investigate the value of aquaporins function with multi b-values diffusion weighted magnetic resonance imaging in the grading diagnosis of astrocytoma.Materials and Methods: Fifty-two patients with cerebral astrocytoma underwent conventional MRI scanning and multi b value DWI scanning before surgery, of which the low-grade group (WHO Ⅰ—Ⅱ grade) were 24 cases, the high-grade group (WHO Ⅱ—Ⅳ grade) were 28 cases. Measuring the AQP-ADC values and conventional ADC values in tumoral solid part. Using independent sample t-test to compare AQP-ADC values and conventional ADC values between the low-grade group and high-grade group, ROC curve was used to compare the diagnostic performance of AQP-ADC values and conventional ADC values.Results: The AQP-ADC value in tumoral solid part of high-grade group was higher than those of low-grade group, and the conventional ADC value in tumoral solid part of high-grade group was lower than those of low-grade group, the AQP-ADC value and conventional ADC value of tumoral solid part had significant differences between the groups (P<0.01). The area under the ROC curve (AUC) of AQP-ADC value and conventional ADC value was 0.891, 0.778 respectively.Conclusions: AQP-ADC value in tumoral solid part could be used to identify low grade astrocytoma from high grade astrocytoma, and was better than conventional ADC value.
[Keywords] Astrocytoma；Brain；Diffusion magnetic resonance imaging

DUAN Xiao-fan Medical Imaging Department of Shanxi Medical University, Taiyuan 030001, China

ZHANG Hui* Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China

WANG Xiao-chun Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China

TAN Yan Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China

QIN Jiang-bo Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China

WANG Le Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China

ZAHNG Lei Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China

*Correspondence to: Zhang H, E-mail: zhanghui_mr@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This study was supported by grants from the National Natural Science Foundation to Hui Zhang No. 81471652 the Natural Science Foundation of Shanxi Province to Yan Tan No. 201601D021162
Received  2016-09-22
Accepted  2016-11-19
DOI: 10.12015/issn.1674-8034.2017.01.004
DOI:10.12015/issn.1674-8034.2017.01.004.

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