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• Clinical Article •
Abnormal amplitude of low-frequency fluctuation associated with relapse behavior in heroin addict: a resting-state functional magnetic resonance image study
LI Lin-bin  LI Zhe  CHEN Jia-jie  LIU Jie-rong  WEI Xu-an  LI Wei  WANG Wei  LI Qiang 

DOI:10.12015/issn.1674-8034.2017.01.006.


[Abstract] Objective: To investigate the characteristics of the relapse related brain function of heroin addicts during the resting state.Materials and Methods: Thirty-one heroin addicts were included in a prospective longitudinal study of resting state functional magnetic resonance imaging. The relapse group and non relapse group were determined after six month-follow-up, and the differences in amplitude of low-frequency fluctuation (ALFF) value between two groups were analyzed. Then the relationship between ALFF value of differential regions and relapse behavior was analyzed.Results: Compared with non relapse group, the relapse group demonstrated significantly greater ALFF value in the right anterior cingulate gyrus, orbitofrontal gyrus and temporal gyrus, demonstrated lower ALFF value in the left parahippocampal gyrus, right posterior cingulate gyrus, bilateral fusiform gyrus and left inferior parietal lobule. No significantly relationship between the ALFF value of differential brain regions and relapse behavior was found.Conclusions: The relapses and non-relapses vary significantly in the brain function, the decline of control function and the abnormal increase of learning and memory function are closely related with relapse behavior. These abnormal functional characteristics have a certain predictive value for the relapse risk of heroin addicts.
[Keywords] Heroin addiction；Relapse；Resting state；Magnetic resonance imaging

LI Lin-bin Company 11, Battalion 3, The First Brigade of Cadets, Fourth Military Medical University, Xi’an, Shaanxi Province, Xi'an 710038, China

LI Zhe Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, Xi'an 710038, China

CHEN Jia-jie Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, Xi'an 710038, China

LIU Jie-rong Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, Xi'an 710038, China

WEI Xu-an Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, Xi'an 710038, China

LI Wei Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, Xi'an 710038, China

WANG Wei Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, Xi'an 710038, China

LI Qiang* Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, Xi'an 710038, China

*Correspondence to: Li Q, E-mail: tdqiangqiang@foxmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by grants from the National Natural Science Foundation of China NO. 81671661, 81371532
Received  2016-11-10
Accepted  2016-12-09
DOI: 10.12015/issn.1674-8034.2017.01.006
DOI:10.12015/issn.1674-8034.2017.01.006.

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