Share：
Share this content in WeChat
X
[Chinese][PDF]73478
• Clinical Article •
Imbalanced communication among brain networks in chronic pain disorder: Meta-analysis of resting-state functional connectivity
CHENG Jian  WU wen 

DOI:10.12015/issn.1674-8034.2017.01.007.


[Abstract] Objective: To describe the change of functional connectivity of resting-state brain in chronic pain status by Meta-analysis.Materials and Methods: A database search was performed in PubMed, EMBASE, Web of Science, and BrainMap for literature published from database establishment to September 2016. Based on inclusion and exclusion criteria, studies supporting fMRI analysis of the resting-state brain in chronic pain were collected. The Talairach coordinates are uniformly transformed into MNI coordinates using Icbm2tal software.Results: Twenty studies were identified with a total of 389 subjects. Meta-analysis showed that chronic pain causes abnormal functioning of the default network. We chose insula as seed, the hyperconnectivity consists between insula and regions of default mode network include anterior cingulate, posterior cingulate, precuneus, inferior parietal lobule and medial prefrontal cortex.Conclusions: Our results suggest that abnormal functional connectivity between insula and default mode networks, may reflect chronic pain towards cognitive control and emotion processing. These findings provide an empirical foundation for a neurocognitive model in which brain network underlies core cognitive and affective abnormalities in chronic pain.
[Keywords] Chronic pain；Functional connectivity；Magnetic resonance imaging；Meta-analysis

CHENG Jian Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China

WU wen* Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China

*Correspondence to: Wu W, E-mail: wuwen66@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by Grants from the National Natural Science Foundation of China (NNSFC), China No. 81473769 and the Natural Science Foundation of Guangdong Province, China No. 2014A030313335
Received  2016-09-29
Accepted  2016-11-27
DOI: 10.12015/issn.1674-8034.2017.01.007
DOI:10.12015/issn.1674-8034.2017.01.007.

[1]
Linnman C, Beucke JC, Jensen KB, et al. Sex similarities and differences in pain-related periaqueductal gray connectivity. Pain, 2012, 153(2): 444-454.
[2]
Otti A, Guendel H, Henningsen P, et al. Functional network connectivity of pain-related resting state networks in somatoform paindisorder: an exploratory fMRI study. J Psychiatr Neurosci, 2013, 38(1): 57-65.
[3]
Ichesco E, Quintero A, Clauw DJ, et al. Schmidt-wilcke, altered functional connectivity between the insula and the cingulate cortex in patients with temporomandibular disorder: a pilot Study. Headache, 2012, 52(3):441-454.
[4]
Kong J, Spaeth RB, Wey HY, et al. S1 is associated with chroniclow back pain: a functional and structural MRI study. Mol Pain, 2013, 9: 43.
[5]
Loggia ML, Kim J, Gollub RL, et al. Default mode network connectivity encodes clinical pain: an arterial spin labeling study. Pain, 2013, 154(1): 24-33.
[6]
Schwedt TJ, Schlaggar BL, Mar S, et al. Atypical resting-state functional connectivity of affective pain regions in chronic migraine. Headache, 2013, 53(5): 737-751.
[7]
Wiech K, Ploner M, Tracey I. Neurocognitive aspects of pain perception. Trends Cognit Sci, 2008, 12(8): 306-313.
[8]
Zhang S, Wu W, Huang G, et al. Resting-state connectivity inthe default mode network and insula during experimental low back pain, Neural Regen Res, 2014, 9(2): 135-142.
[9]
Hubbard CS, Khan SA, Keaser ML, et al. Altered brain structure and function correlate with disease severity and pain catastrophizing in migraine patients. eNeuro, 2014, 1(1): e20.
[10]
Derbyshire SW. Exploring the pain "neuromatrix" . Curr Rev Pain, 2000, 4(6): 467-477.
[11]
Vincent JL, Kahn I, Snyder AZ, et al. Evidence for a frontoparietalcontrol system revealed by intrinsic functional connectivity. J Neurophysiol, 2008, 100(6): 3328-3342.
[12]
Ichesco E, Schmidt-Wilcke T, Bhavsar R, et al. Altered resting state connectivity of theinsular cortex in individuals with fibromyalgia. Pain, 2014, 15(8): 815-823.
[13]
Raichle EM, Snyder AZ. A default mode of brain function: abrief history of an evolvingidea. Neuroimage, 2007, 37(4): 1083-1090.
[14]
Pyka M, Beckmann CF, Schöning S, et al. Impact of working memory load on fMRI resting state pattern in subsequent resting phases. PloS One, 2008, 4(9): e7198.
[15]
Turkeltaub PE, Eden GF, Jones KM, et al. Meta-analysis of the functional neuro anatomy of single-word reading: method and validation. Neuroimage, 2002, 16(3Pt 1): 765-780.
[16]
Eickhoff SB, Laird AR, Grefkes C, et al. Coordinate-basedactivation likelihood estimation Meta-analysis of neuroimaging data: a random-effects approachbased on empirical estimates of spatial uncertainty. Hum Brain Mapp, 2009, 30(9): 2907-2926.
[17]
Mainero C, Boshyan J, Hadjikhani N, et al. Altered functional magnetic resonance imagingresting-state connectivity in periaqueductal gray networks in migraine. Ann Neurol, 2011, 70(5): 838-845.
[18]
Schmidt-Wilcke T, Ichesco E, Hampson JP, et al. Resting state connectivity correlates with drug and placebo response in fibromyalgiapatients. Neuroimage Clin, 2014, 6: 252-261.
[19]
Kutch JJ, Yani MS, Asavasopon S, et al. Altered resting stateneuromotor connectivity in men with chronic prostatitischronic pelvic pain syndrome. A MAPP: research network neuroimaging study. Neuroimage Clin, 2015, 8: 493-502.
[20]
Flodin P, Martinsen S, Mannerkorpi K, et al. Normalization of aberrant resting state functional connectivity in fibromyalgia patients following a three month physical exercise therapy. Neuroimage Clinl, 2015, 9: 134-139.
[21]
Flodin P, Martinsen S, Altawil R, et al. Intrinsic brain connectivity in chronic pain: a resting-state fmri study in patients with rheumatoid arthritis. Front Hum Neurosci, 2016, 10: 107.
[22]
Wang T, Chen N, Zhan W, et al. Altered effective connectivity of posterior thalamus in migraine with cutaneous allodynia: aresting-state fMRI study with granger causality analysis. J Headache Pain, 2016, 17: 17.
[23]
Cauda F, D'Agata F, Sacco K, et al. Altered resting state attentional networks in diabetic neuropathic pain. J Neurol Neurosurg Psychiatry, 2010, 81(7): 806-811.
[24]
Mayhew SD, Hylands-White N, Porcaro C, et al. Intrinsicvariability in the human response to pain is assembled from multiple, dynamic brain processes. Neuroimage, 2013, 75: 68-78.
[25]
Moulton EA, Becerra L, Johnson A, et al. Altered hypothalamic functional connectivity with autonomic circuits and the locus coeruleus in migraine. PloS One, 2014, 9(4): e95508.
[26]
Hong JY, Kilpatrick LA, Labus J, et al. Patients with chronic visceral pain show sex-related alterations in intrinsic oscillations of the resting brain. J Neurosci, 2013, 33(29): 11994-12002.
[27]
Cservenka A, Stein H, Wilson AC, et al. Neurobiological phenotypes of familial chronic pain in adolescence: a pilot fMRI study. J Pain, 2015, 16(9): 913-925.
[28]
Cummiford CM, Nascimento TD, Foerster BR, et al. Changes in resting state functional connectivity after repetitive transcranial directcurrent stimulation applied to motor cortex in fibromyalgia patients. Arthritis Res Ther, 2016, 18: 40.
[29]
Fujiwara J, Tobler PN, Taira M, et al. Segregated and Integrated Coding of Reward and Punishment in the Cingulate Cortex. J Neurophysiol, 2009, 101(6): 3284-3293.
[30]
Wey H, Catana C, Hooker JM, et al. Simultaneous fMRI-PET of the opioidergic pain system inhuman brain. Neuroimage, 2014, 102(Pt 2): 275-282.
[31]
Napadow V, LaCount L, Park K, et al. Intrinsic brainconnectivity in fibromyalgia is associated with chronic pain intensity. Arthritis Rheum, 2010, 62(8): 2545-2555.
[32]
Blessing EM, Beissner F, Schumann A, et al. A data-driven approach tomapping cortical and subcortical intrinsic functional connectivity along the longitudinal hippocampal axis. Hum Brain Mapp, 2016, 37(2): 462-476.
[33]
Cauda F, Sacco K, D' Agata F, et al. Low-frequency BOLD fluctuations demonstrate altered thalamocortical connectivity in diabeticneuropathic pain. BMC Neurosci, 2009, 138(10): 1-14.
[34]
Turkeltaub PE, Eden GF, Jones KM, et al. Meta-analysis of the functional neuroanatomy of single-word reading: method and validation. Neuroimage, 2002, 16(3Pt 1): 765-780.
[35]
Baliki MN, Geha PY, Apkarian AV, et al. Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics. J Neurosci, 2008, 28(6):1398-1403
[36]
Banks SJ, Eddy KT, Angstadt M, et al. Amygdala-frontal connectivity during emotion regulation. Soc Cogn Affect Neurosci, 2007, 2(4): 303-312.
[37]
Duke Han S, Buchman AS, Arfanakis K, et al. Bennett, Functional connectivity networks associated with chronic musculoskeletal pain in old age. Int J Geriatr Psych, 2013, 28(8): 858-867.
[38]
Tessitore A, Russo A, Giordano A, et al. Disrupted default mode network connectivity in migraine without aura. J Headache Pain, 2013, 14: 89.

PREV Abnormal amplitude of low-frequency fluctuation associated with relapse behavior in heroin addict: a resting-state functional magnetic resonance image study
NEXT CT and MRI diagnosis of central nervous system neuroblastomas (a report of 6 cases)
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn