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Analysis of the main factors affecting quantitative dynamic contrast-enhanced MR imaging
DU Yong-hao  NIU Gang  YANG Jian 

DOI:10.12015/issn.1674-8034.2017.01.019.


[Abstract] DCE-MRI is based on the serial acquisition of the fast T1WI. Through multi-phase contrast enhanced scanning, the time-signal intensity curve of the region-of-interest (ROI) can be acquired. Meanwhile, the quantitative parameters reflecting tissue perfusion and vascular permeability are obtained by selecting the proper pharmacokinetic model. This method has been widely applied in many clinical aspects, including tumor diagnosis, assessment of therapeutic response and prognostic evaluation. In this paper, we conducted a systematic review focused on main factors that may influence DCE-MRI outcomes. These factors include scanning protocol, arterial input functions (AIF), the motion displacement and the pharmacokinetic models. Optimizing these main factors may improve the reproducibility and accuracy of the DCE-MRI results.
[Keywords] Magnetic resonance imaging；Dynamic contrast-enhanced；Quantitative analysis

DU Yong-hao Department of Radiology, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China

NIU Gang* Department of Radiology, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China

YANG Jian* Department of Radiology, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China

*Correspondence to: NIU Gang, E-mail: niugang369@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Supported by the Project of Science and Technology of Social Development in Shaanxi Province.
Received  2016-09-03
Accepted  2016-11-20
DOI: 10.12015/issn.1674-8034.2017.01.019
DOI:10.12015/issn.1674-8034.2017.01.019.

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