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• ASL Papers •
A correlation study between the cerebral perfusion of arterial spin labeling of MRI and neuropsychological scale in patients with Alzheimer's disease and mild cognitive impairment
ZHOU Xiu-mei  LI Kun-cheng 

DOI:10.12015/issn.1674-8034.2017.02.001.


[Abstract] Objective: To investigate the changes of cerebral blood flow perfusion, cognitive function and the relationship between AD and MCI patients.Materials and Methods: Xuanwu Hospital of Capital Medical University neurology memory disorders clinic diagnosed 30 AD patients and 30 MCI patients and 30 cases with age, sex and level of education that match the normal old people as control group (NC group). Using 2D continuity ASL (arterial spin labeling) semi-quantitative measurement of local cerebral blood flow and neuropsychological scale joint assessment of cerebral perfusion in patients with AD and cognitive status. The cognitive state and the characteristics of cerebral perfusion of the three groups were analyzed, and the correlation between cognitive function and cerebral perfusion was analyzed also.Results: (1) The age, sex, years of education were compared in three groups of subjects, and the difference was not statistically significant (P>0.05). The differences of MMSE and MOCA scores had statistical significance in three groups (P<0.05). (2) The signal intensity of the bilateral temporal, parietal lobes and corona radiata of cerebral white matter in AD and MCI groups were reduced, the comparison of the three groups was statistically significant between the two-two groups. (3) The correlated analysis of the cerebral perfusion signal intensity and the MMSE and MOCA scores in AD and MCI patients, with two factors correlation analysis, found that the signal intensities of the bilateral temporal, and parietal lobes were positively correlated with MMSE and MoCA scores.Conclusion: (1) ASL provides an objective indicator for early diagnosis of AD and MCI in evaluating cerebral blood flow perfusion. (2)There was a good correlation between MMSE and MoCA scores and ASL cerebral perfusion of MRI, and the diagnostic accuracy of AD and MCI could be improved by the combination of the two examinations.
[Keywords] Alzheimer disease；Mild cognitive impairment；Arterial spin labeling；Neuropsychological scale；Magnetic resonance imaging

ZHOU Xiu-mei Beijing Jiangong Hospital, Beijing 100054, China

LI Kun-cheng* Xuanwu Hospital of Capital Medical University, Beijing 100053, China

*Correspondence to: Li KC, E-mail: cjr.likuncheng@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Nature Science Foundation of China No. 81471649
Received  2016-09-04
Accepted  2016-12-11
DOI: 10.12015/issn.1674-8034.2017.02.001
DOI:10.12015/issn.1674-8034.2017.02.001.

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