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• ASL Papers •
The short-term effect of cigarette and coffee on regional cerebral blood flow measured with arterial spin labeling
TAN Bo-wen  LV Fa-jin 

DOI:10.12015/issn.1674-8034.2017.02.002.


[Abstract] Objective: To investigate the short-term effects of smoking and drinking coffee on regional cerebral blood flow (rCBF) in healthy adults.Materials and Methods: Forty-one healthy male volunteers (age range 22—55 years old , average age 36.6±11.8 years old) were divided into two groups: 21 volunteers with smoking habit were selected into smoking group, 20 volunteers without smoking habit were selected into non-smoking group. All of them were performed with smoking test. 19 volunteers (age range 22—27 years old, average age 24.4±1.4 years old) were performed with drinking coffee test. Before and after test, measuring rCBF of occipital lobe, frontal lobe, temporal lobe’s gray matter and thalamus,basal ganglia with 3D-arterial spin labeling technology (3D-ASL).Results: (1) rCBF of 41 volunteers had no significant difference (P>0.05) before and after smoking. (2) 21 smokers showed a lower rCBF than 20 non-smokers before smoking and rCBF in region of bilateral occipital lobe, temporal lobe, thalamus, left basal ganglia had significant difference (P<0.05). (3) rCBF of 19 volunteers in region of bilateral occipital lobe, frontal lobe, temporal lobe gray matter and thalamus, basal ganglia showed significant decrease (P<0.05) after drinking coffee. The decline rate was 14.5%, 16.5%, 11.6%, 16.5%, 17.6%, 15.7%, 14.0%, 14.3%, 14.4%, 15.4%, respectively. rCBF in the right temporal lobe had a significant change.Conclusion: To detect the short-term effect of smoking and intaking coffee on gray matters' rCBF in healthy adults based on 3D ASL technology, we found that drinking coffee can lead to an acute reduction in rCBF. Though somking had no short-term impact on rCBF, it can lead to rCBF's reduction in the long run.
[Keywords] Arterial spin labeling；Cerebral blood flow；Smoking；Coffee；Magnetic resonance imaging

TAN Bo-wen The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LV Fa-jin* The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

*Correspondence to: Lv FJ, E-mail: fajinlv@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by the National Key Clinical Specialist Construction Programs of China No. [2013]544
Received  2016-09-17
Accepted  2016-11-15
DOI: 10.12015/issn.1674-8034.2017.02.002
DOI:10.12015/issn.1674-8034.2017.02.002.

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