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• Clinical Article •
Observing the changes of regional homogeneity in adults after sleep deprivation with different times by resting state fMRI
LI Ji-yuan  SONG Yun-long  QI Jian-lin  WU Yao  PAN Zhi-bin 

DOI:10.12015/issn.1674-8034.2017.02.004.


[Abstract] Objective: To investigate the changes of sleep deprivation (SD) with different times on human brain regional homogeneity (ReHo).Materials and Methods: Twenty-eight healthy individuals participated in this study. Resting-state fMRI scans were collected under rest wakefulness and 24 and 36 hours SD. The ReHo approach was employed to analyze the imaging data, and SPM8 was used to perform one-way ANOVA, with a P value<0.001 (corrected FWE) and cluster size (k value)>20 voxels considerate statistic significant.Results: Compared with rest wakefulness, mainly SD induced enhanced brain ReHo in the right fusiform, the frontal, temporal lobe and the left thalamus; decreased ReHo in the right precuneus, supramarginal and the left frontal middle lobe, postcentral. With SD times went on, enhanced brain ReHo were found in precuneus, angular and frontal sup medial; and decreased ReHo were found in the precentral gyrus, temporal lobe and medial frontal gyrus.Conclusion: SD caused abnormal changes in whole brain network changes by connection of multiple brain regions, especially the brain regions which are mainly in the frontal lobe, temporal lobe and thalamus. And the SD times can reflect the changes of ReHo in functional regions.
[Keywords] Magnetic resonance imaging, functional；Sleep deprivation；Regional homogeneity；Brain；Adult

LI Ji-yuan Department of MRI, Air Force General Hospital, PLA, Beijing 100142, China

SONG Yun-long* Department of MRI, Air Force General Hospital, PLA, Beijing 100142, China

QI Jian-lin Department of Clinical Psychology, Air Force General Hospital, PLA, Beijing 100142, China

WU Yao Department of MRI, Air Force General Hospital, PLA, Beijing 100142, China

PAN Zhi-bin Department of MRI, Air Force General Hospital, PLA, Beijing 100142, China

*Correspondence to: Song YL, E-mail: ylsong@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Beijing Natural Science Foundation No. 7152145
Received  2016-10-28
Accepted  2016-12-20
DOI: 10.12015/issn.1674-8034.2017.02.004
DOI:10.12015/issn.1674-8034.2017.02.004.

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