Share：
Share this content in WeChat
X
[Chinese][PDF]883116
• Clinical Article •
Observing the changes of regional homogeneity in adults after sleep deprivation with different times by resting state fMRI
LI Ji-yuan  SONG Yun-long  QI Jian-lin  WU Yao  PAN Zhi-bin 

DOI:10.12015/issn.1674-8034.2017.02.004.


[Abstract] Objective: To investigate the changes of sleep deprivation (SD) with different times on human brain regional homogeneity (ReHo).Materials and Methods: Twenty-eight healthy individuals participated in this study. Resting-state fMRI scans were collected under rest wakefulness and 24 and 36 hours SD. The ReHo approach was employed to analyze the imaging data, and SPM8 was used to perform one-way ANOVA, with a P value<0.001 (corrected FWE) and cluster size (k value)>20 voxels considerate statistic significant.Results: Compared with rest wakefulness, mainly SD induced enhanced brain ReHo in the right fusiform, the frontal, temporal lobe and the left thalamus; decreased ReHo in the right precuneus, supramarginal and the left frontal middle lobe, postcentral. With SD times went on, enhanced brain ReHo were found in precuneus, angular and frontal sup medial; and decreased ReHo were found in the precentral gyrus, temporal lobe and medial frontal gyrus.Conclusion: SD caused abnormal changes in whole brain network changes by connection of multiple brain regions, especially the brain regions which are mainly in the frontal lobe, temporal lobe and thalamus. And the SD times can reflect the changes of ReHo in functional regions.
[Keywords] Magnetic resonance imaging, functional；Sleep deprivation；Regional homogeneity；Brain；Adult

LI Ji-yuan Department of MRI, Air Force General Hospital, PLA, Beijing 100142, China

SONG Yun-long* Department of MRI, Air Force General Hospital, PLA, Beijing 100142, China

QI Jian-lin Department of Clinical Psychology, Air Force General Hospital, PLA, Beijing 100142, China

WU Yao Department of MRI, Air Force General Hospital, PLA, Beijing 100142, China

PAN Zhi-bin Department of MRI, Air Force General Hospital, PLA, Beijing 100142, China

*Correspondence to: Song YL, E-mail: ylsong@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Beijing Natural Science Foundation No. 7152145
Received  2016-10-28
Accepted  2016-12-20
DOI: 10.12015/issn.1674-8034.2017.02.004
DOI:10.12015/issn.1674-8034.2017.02.004.

[1]
徐健，颜崇淮，沈晓明．睡眠剥夺损害学习记忆能力的研究．中国预防医学杂志, 2004, 38(2): 134-137.
[2]
赵明霞，赵忠新，彭华，等．功能磁共振成像研究睡眠剥夺36小时对健康男性工作记忆的影响．中华神经科杂志, 2010, 43(10): 716-720.
[3]
王富贵，邵永聪，齐建林，等．睡眠剥夺对青年男性执行功能的影响．中国心理卫生杂志, 2010, 24(7): 541-545.
[4]
Zang Y, Jiang T, Lu Y, et a1. Regional homogeneity approach to fMRI data analysis．Neuroimage, 2004, 22(1): 394-400．
[5]
戴西件，龚洪翰,闵友江，等. fMRI观察静息状态下健康人睡眠剥夺前后脑局部一致性差异．中国医学影像技术, 2012, 28(2): 243-246.
[6]
郑玲，张志强，田蕾，等．联合脑电功能MRI观察颞叶癫痫脑活动局域的一致性改变．中国医学影像技术, 2010, 26(11): 2045-2047．
[7]
Mu Q, Nahas Z, Johnson KA, et al. Decreased cortical response to verbal working memory following sleep deprivation. Sleep, 2005, 28(1): 55-67.
[8]
雷煜，王路斌，邵永聪，等．睡眠剥夺影响大脑情绪功能网络的静息态功能磁共振成像研究．第三军医大学学报, 2015, 37(22): 2278-2284.
[9]
Durmer JS, Dinges DF. Neurocognitive consequences of sleep deprivation. Semin Neurol, 2005, 25(1): 117-129.
[10]
叶恩茂，邵永聪，毕国华，等．睡眠剥夺对静息态脑功能默认网络的影响．南方医科大学学报, 2009, 29(12): 2523-2532.
[11]
Chee MW, Chuah LY, Venkatraman V, et al. Functional imaging of working memory following normal sleep and after 24 and 35 h of sleep deprivation: Correlations of fronto-parietal activation with performance. Neuroimage, 2006, 31(1): 419-428.
[12]
Verweij IM, Romeijn N, Smit DJ, et al. Sleep deprivation leads to a loss of functional connectivity in frontal brain regions. BMC Neurosci, 2014, 15(1): 88.
[13]
Jackson ML, Gunzelmann G, Whitney P, et al. Deconstructing and reconstructing cognitive performance in sleep deprivation. Sleep Med Rev, 2013, 17(3): 215-225.
[14]
Joo EY, Yoon CW, Koo DL, et al. Adverse effects of 24 hours of sleep deprivation on cognition and stress hormones. J Clin Neurol, 2012, 8(2): 146-150.
[15]
Osaka M, Komori M, Morishita M, et al. Neural bases of focusing attention in working memory: an fMRI study based on group differences. Cogn Affect Behav Neurosci, 2007, 7(2): 130-139.

PREV Research progress of arterial spinlabeling in ischemic cerebrovascular disease
NEXT The abnormal salience network of the brain in heroin addicts: A resting-state functional magnetic resonance image study based on independent component analysis
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn