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• Clinical Article •
The abnormal salience network of the brain in heroin addicts: A resting-state functional magnetic resonance image study based on independent component analysis
CHEN Jia-jie  LIU Jie-rong  WEI Xuan  LI Yong-bin  ZHU Jia  LI Wei  WANG Wei  LI Qiang 

DOI:10.12015/issn.1674-8034.2017.02.005.


[Abstract] Objective: To investigate the characteristics of the salience network in heroin addicts.Materials and Methods: Twenty-six heroin addicts and thirty-nine healthy controls were enrolled in the resting-state functional magnetic resonance imaging scan. Independent component analysis was used to identify the salience network from the image data, the difference in strength of functional connectivity within the core brain areas of salience network between the two groups was analyzed, then the relationship between total heroin consumption and strength of connectivity of differential regions was analyzed.Results: Compared with the healthy controls, the functional connectivity of the left insula was significantly greater in the heroin addicts. And the functional connectivity of insula was positively correlated with the heroin consumption (P=0.02, r=0.46).Conclusion: Long-term heroin use results in abnormally increased functional connectivity of salience network in heroin addicts. The salience network plays a key role in heroin addicitoin.
[Keywords] Heroin addicts；Salience network；Insula；Independent component analysis；Magnetic resonance imaging, functional；Functional connectivity

CHEN Jia-jie Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, China

LIU Jie-rong Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, China

WEI Xuan Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, China

LI Yong-bin Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, China

ZHU Jia Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, China

LI Wei Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, China

WANG Wei Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, China

LI Qiang* Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, China

*Correspondence to: Li Q, E-mail: 83341951@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81671661, 81371532
Received  2016-11-10
Accepted  2016-12-13
DOI: 10.12015/issn.1674-8034.2017.02.005
DOI:10.12015/issn.1674-8034.2017.02.005.

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