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• Clinical Article •
Type 2 diabetes and apparent diffusion coefficients of the cerebral cortex associated with specific functions on brain MRI
ZHAO Jian-hong  YANG Hai-ting  ZHOU Jun-lin  BAI Liang-cai  LIU Hong  JIANG Jian  ZHAO Jun 

DOI:10.12015/issn.1674-8034.2017.02.007.


[Abstract] Objective: To detect whether there is any change of apparent diffusion coefficients (ADC) levels in different sites of the brain, particularly in areas associated with the memory, the emotion and the vision in type 2 diabetic patients with retinopathy by measuring diffusion-weighted imaging (DWI).Materials and Methods: Conventional magnetic resonance imaging (MRI) and DWI of the brain were obtained from 40 diabetic patients: 20 patients with proliferative diabetic retinopathy (group Ⅰ), 20 diabetic patients with simple diabetic retinopathy (group Ⅱ) and 20 age-matched healthy volunteers (group Ⅲ). ADC values of midfrontal gyrus, superior temporal gyrus and cuneate gyrus were obtained.Results: There is no significant difference in routine T1 or T2 weighted imaging between the three group. The ADC values of bilateral midfrontal gyrus and superior temporal gyrus cortex significantly increased in group Ⅰ and Ⅱ compared to group Ⅲ (P<0.05). The duration of disease positively correlated with ADC values of the right midfrontal gyrus in group Ⅰ and Ⅱ.Conclusion: We found increases in ADC values supporting the neuronal degeneration and poptosis in some regions, especially in midfrontal gyrus and superior temporal gyrus by DWI in the diabetic patients with retinopathy. This result supports the association between diabetic retinopathy and brain injury, and with the progression of disease, the brain injury may be further aggravation.
[Keywords] Cerebral cortical；Magnetic resonance imaging；Diabetes mellitus, type 2；Diffusion weighted imaging；Apparent diffusion coefficients；Diabetic retinopathy

ZHAO Jian-hong Department of Radiology, the Second Hospital of Lanzhou University, Lanzhou 730000, China

YANG Hai-ting Department of Radiology, the Second Hospital of Lanzhou University, Lanzhou 730000, China

ZHOU Jun-lin* Department of Radiology, the Second Hospital of Lanzhou University, Lanzhou 730000, China

BAI Liang-cai Department of Radiology, the Second Hospital of Lanzhou University, Lanzhou 730000, China

LIU Hong Department of Radiology, the Second Hospital of Lanzhou University, Lanzhou 730000, China

JIANG Jian Department of Radiology, the Second Hospital of Lanzhou University, Lanzhou 730000, China

ZHAO Jun Department of Radiology, the Second Hospital of Lanzhou University, Lanzhou 730000, China

*Correspondence to: Zhou JL, E-mail: zjl601@163.com

Conflicts of interest   None.

Received  2016-07-25
Accepted  2016-12-15
DOI: 10.12015/issn.1674-8034.2017.02.007
DOI:10.12015/issn.1674-8034.2017.02.007.

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