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• Clinical Article •
The correlation between ADC value and DCE-MRI parameters of magnetic resonance imaging in different degree of differentiation of rectal cancer
SHEN Wen-yi  XU Xiang-jiu  HUANG Gang  CHEN Lu-fang  CHANG Fei-xia  MA Xiao-mei 

DOI:10.12015/issn.1674-8034.2017.02.009.


[Abstract] Objective: To investigate the correlation between ADC value and the characteristics of dynamic contrast-enhanced MRI (DCE-MRI) parameters in the diagnosis of rectal cancer with different degree of differentiation.Materials and Methods: According to the degree of differentiation of the tumor, 102 cases of rectal adenocarcinoma were divided into: well differentiated group (n=23), moderately differentiated group (n=59) and poorly differentiated group (n=20). The DWI and DCE-MRI images of different groups were retrospectively analyzed, their ADCmean values, Ktrans, Ve and Kep values were measured, and the correlation between ADCmean value and Ktrans, Ve and Kep values in different groups was analyzed.Results: The values of ADCmean, Ktrans, Ve, Kep in well differentiation group were: (1.13±0.25) mm2/s, (0.28±0.09) min-1, (0.46±0.15), (0.67±0.18) min-1; The values of ADCmean, Ktrans, Ve, Kep in moderately differentiation group were: (0.94±0.05) mm2/s, (0.28±0.09) min-1, (0.52±0.24), (0.63 ±0.25) min-1; The values of ADCmean, Ktrans, Ve, Kep in poorly differentiation group were: (0.79±0.07) mm2/s, (0.40 ±0.08) min-1, (0.67±0.16), (0.66±0.15) min-1, Kep values between the groups and Ktrans, Ve between the moderately-well differentiated group were not statistically significant (P<0.05), and the rest were statistically significant (P<0.05). In poorly and moderately differentiation group of rectal cancer, the ADCmean and Ktrans value was negatively correlated (rmoderately=0.34, rpoorly=0.60, P<0.05). The Pearson analysis of ADCmean and Ve, Kep value in different differentiation group was P>0.05, the difference was not statistically significant. With the increase of the degree of differentiation of rectal cancer, ADCmean value increased, Ktrans value decreased.Conclusion: (1) There was a certain correlation between ADCmean value and Ktrans value of rectal cancer in poorly and moderately differentiation group. (2) The correlation between ADCmean value and Ktrans value of the well differentiation group and the moderately and poorly differentiation group were different, which had important guiding significance to determine the pathological differentiation and malignant degree of rectal cancer.
[Keywords] Rectal neoplasms；Magnetic resonance imaging；Diffusion weighted imaging；Apparent diffusion coefficient；Dynamic contrast enhanced

SHEN Wen-yi Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

XU Xiang-jiu* Department of Radiology, Gansu Provincial People's Hospital, Lanzhou 730000, China

HUANG Gang Department of Radiology, Gansu Provincial People's Hospital, Lanzhou 730000, China

CHEN Lu-fang Zhengzhou Children's Hospital, Zhengzhou 450000, China

CHANG Fei-xia Dunhuang Hospital of Gansu province, Dunhuang 736200, China

MA Xiao-mei Department of Radiology, Gansu Provincial People's Hospital, Lanzhou 730000, China

*Correspondence to: Xu XJ, E-mail: xvxiangjiu@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This paper is supported by the Gansu provincial Health Industry Research Project No. GSWST2013-01
Received  2016-10-25
Accepted  2016-12-20
DOI: 10.12015/issn.1674-8034.2017.02.009
DOI:10.12015/issn.1674-8034.2017.02.009.

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