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• Original Article •
Quantification of myocardial T1 mapping in minipig with chronic myocardial ischemia
CHEN Yuan-yuan  FANG Ji-liang  LIU Gui-yong  YU Yu-tian  HE Yi  HONG Yang  LUO Ping  RONG Pei-jing 

DOI:10.12015/issn.1674-8034.2017.02.011.


[Abstract] Objective: The purpose of this study is to quantify the myocardial T1 mapping values in minipig modelling for chronic myocardial ischemia.Materials and Methods: The minipigs were implanted the protein constriction ring (Ameroid) at left anterior descending artery to induce ischemia. The minipigs were scanned twice in a 3.0 T MRI scanner at the short axial slices of the apex, the papillary muscle, at the time of the baseline of the normal heart and at the 4th week after the operation with the chronic myocardial ischemia. The independent-samples t test was employed to analyze the difference of the T1 mapping values of the heart muscles between the two conditions.Results: In this study, 12 minipigs completed CMRI scan before modeling, The unenhanced myocardial average T1 values was (1108.9±10.5) ms, the mean myocardial T1 values were (1050.2±16.7) ms and (1139.7±54.4) ms respectively at the apex and papillary muscle myocardium, the difference was statistically significant. There were 11 minipigs completed CMR scan after modeling, the apical myocardial average T1 values was (1210.6±94.2) ms, it was higher than baseline, the difference was statistically significant. The mean myocardial T1 value of the papillary muscle was (1236.0±114.3) ms at chronic ischemia minipigs, no significant difference with baseline. Furthermore, statistically significant differences existed in the anterior and anteroseptal of the papillary muscle.Conclusion: The T1 mapping technique is valuable as a new important index for the diagnosis of chronic ischemic myocardium.
[Keywords] Minipig；Myocardial ischemia；Magnetic resonance imaging；T1 mapping；Anterior wall of the left ventricle；Models, animal

CHEN Yuan-yuan Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

FANG Ji-liang* Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

LIU Gui-yong Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

YU Yu-tian Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China

HE Yi Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, China

HONG Yang Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

LUO Ping Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

RONG Pei-jing* Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China

*Correspondence to: Fang JL, E-mail: fangmgh@163.com; Rong PJ, E-mail: drrongpj@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by National Basic Research Program of China 973 Program, No. 2012CB518503 National Natural Science Foundation of China No. 81273674
Received  2016-08-08
Accepted  2016-10-23
DOI: 10.12015/issn.1674-8034.2017.02.011
DOI:10.12015/issn.1674-8034.2017.02.011.

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