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Advances of diffusion tensor imaging in fetal brain development
MIAO Dan-tong  ZHANG Bing  ZHU Bin 

DOI:10.12015/issn.1674-8034.2017.02.015.


[Abstract] Fetal brain is extraordinarily complex and functional, yet its origin is a simple tubular structure at the end of 3 gestational week. During this period, it undergoes brain primitive induction development, nerve cells proliferation, neuronal migration, bilateral cerebral hemisphere stratum formation, ditch, crack, brain development, white matter fibers appearance and myelination. These developmental processes are extremely precise and complex, but follow a strict sequence. Prenatal ultrasound can only screen obvious congenital anomalies during early pregnancy, but has not yet assessed the development of these subtle brain structure. In recent years, the development of magnetic resonance imaging technology for the development of fetal brain provides a useful tool, in particular, diffusion tensor imaging provides a microstructure observation of fetal brain information perspective by detecting water dispersion movement of brain tissue. Histopathologic examination can provide complementary information. The advantages and application of DTI in fetal brain will be briefly introduced in this review. DTI can display the cortical lamellar structure and the time and sequence of white matter fiber bundles, the changes of connective fiber bundles of fetal brain, myelin maturation process and so on. The main technical problems and solutions of DTI technique for fetal brain imaging are also summarized, which will lay a theoretical foundation for the further application of diffusion tensor imaging in normal fetal brain development.
[Keywords] Diffusion magnetic resonance imaging；Fiber tack；Fetal development；Magnetic resonance imaging

MIAO Dan-tong Department of Radiology, Nanjing Drum Tower Hospital Clinical Collgeg of Nanjing Medical University, Nanjing 210008, China

ZHANG Bing* Department of Radiology, Nanjing Drum Tower Hospital Clinical Collgeg of Nanjing Medical University, Nanjing 210008, China

ZHU Bin Department of Radiology, Nanjing Drum Tower Hospital Clinical Collgeg of Nanjing Medical University, Nanjing 210008, China

*Correspondence to: Zhang B, E-mail: zhangbing_nanjing@vip.163.com

Conflicts of interest   None.

Received  2016-10-08
Accepted  2016-11-18
DOI: 10.12015/issn.1674-8034.2017.02.015
DOI:10.12015/issn.1674-8034.2017.02.015.

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