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Progress of PWI' application in the brain damage of diabetes
WANG Shan-cheng  LI Cheng  QU Hang  DU Fang 

DOI:10.12015/issn.1674-8034.2017.02.016.


[Abstract] Diabetic brain damage is a complication of diabetes in the central nervous system. The brain perfusion abnormalities is one of the manifestations of diabetic brain damage. Magnetic resonance perfusion imaging (PWI) can reflect the information of microcirculation, is divided into three categories, which are dynamic susceptibility contrast enhancement (DSC), dynamic contrast enhancement (DCE) and arterial spin labeling (ASL). With the development of magnetic resonance perfusion imaging, we get more early, comprehensive and accurate measurement of changes in the brain’s microcirculation. Especially, the ASL is a noninvasive method of PWI, it can be a quantitative and repeated way to meansure cerebral blood flow (CBF) and can avoid the risks bring by exogenous contrast agent effectively. ASL has been a powerful tool in diabetic research. This paper focuses on the research and application of PWI in the brain damage of diabetes.
[Keywords] Diabetic brain damage；Diabetic encephalopathy；Diabetes complications；Magnetic resonance imaging；Perfusion weighted imaging；Arterial spin labeling

WANG Shan-cheng Department of Medical Imaging, the First People’s Hospital of Yangzhou, the Second Clinical Medical College of Yangzhou University, Yangzhou 225001, China

LI Cheng Department of Radiology, Zhongda Hospital affiliated to Southeast University, Nanjing 210000, China

QU Hang Department of Medical Imaging, the First People’s Hospital of Yangzhou, the Second Clinical Medical College of Yangzhou University, Yangzhou 225001, China

DU Fang* Department of Medical Imaging, the First People’s Hospital of Yangzhou, the Second Clinical Medical College of Yangzhou University, Yangzhou 225001, China

*Correspondence to: Du F, E-mail: yzdufang@126.com

Conflicts of interest   None.

Received  2016-10-10
Accepted  2016-11-26
DOI: 10.12015/issn.1674-8034.2017.02.016
DOI:10.12015/issn.1674-8034.2017.02.016.

[1]
刘桂锋，姚铭，陈琰. MRI血管及灌注成像对糖尿病患者脑血管病变的应用研究．磁共振成像, 2013, 5(4): 321-324.
[2]
Reske-Nielsen E, Lundbaek K. Pathological changes in the central and peripheral nervous system of young long-term diabetics. II. The spinal cord and peripheral nerves. Diabetologia, 1968, 4(1): 34-43.
[3]
Van Elderen SG, deRoos A, de Craen AJ, et al. Progression of brain atrophy and cognitive decline in diabetes mellitus: a 3-year follow-up. Neurology, 2010, 75(11): 997-1002.
[4]
Strachan MW, Reynolds RM, Marioni RE, et al. Cognitive function, dementia and type 2 diabetes mellitus in the elderly. Nat Rev Endocrinol, 2011, 7(2): 108-114.
[5]
Van den Berg E, Reijmer YD, de Bresser J, et al. A 4 year follow-up study of cognitive functioning in patients with type 2 diabetes mellitus. Diabetologia, 2010, 53(1): 58-65.
[6]
Wu HX, Zhou JF. Elderly diabetic patients with microvascular between complications of radical relationship. Chin J Geriatrics, 2002, 21(4): 60.
[7]
Manschot SM, Brands AM, van der Grond J, et al. Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes. Diabetes, 2006, 55(4): 1106-1113.
[8]
Dalal PM, Parab PV. Cerebrovascular disease in type 2 diabetes mellitus. Neurol India, 2002, 50(4): 380-385.
[9]
Hayashi K, Kurioka S, Yamaguchi T, et al. Association of cognitive dysfunction with hippocampal atrophy in elderly Japanese people with type 2 diabetes. Diabetes Res Clin Pract, 2011, 94(2): 180-185.
[10]
Roberts RO, Knopman DS, Przybelski SA, et al. Association of type 2 diabetes with brain atrophy and cognitive impairment. Neurology, 2014, 82(13): 1132-1141.
[11]
瞿航，高君艳，李澄，等. 2型糖尿病患者大脑灰质结构和神经活动协同性的磁共振成像研究．临床放射学杂志, 2016, 35(14): 512-517.
[12]
Hsu JL, Chen YL, Leu JG, et al. Microstructural white matter abnormalities in type 2 diabetes mellitus: a diffusion tensor imaging study. Neuroimage, 2012, 59(2): 1098-1105.
[13]
刘代洪，段姗姗，张久权，等. 2型糖尿病伴轻度认知功能障碍患者脑静息态功能MRI研究．磁共振成像, 2015, 6(3): 161-167.
[14]
Sahin I, Alkan A, Keskin L, et al. Evaluation of in vivo cerebral metabolism on proton magnetic resonance spectroscopy in patients with impaired glucose tolerance and type 2 diabetes mellitus. J Diabetes Complications, 2008, 22(4): 254-260.
[15]
王倩，伍建林．多模态MRI在T2DM性脑损伤评价的实验及临床研究．天津：天津医科大学, 2014.
[16]
徐嬿，冷晓明，郑芸，等. 3.0 T DCE-MRI定量分析在前列腺癌与增生鉴别诊断中的应用价值．磁共振成像, 2015, 6(8): 608-612.
[17]
Bruce A, Berkowitz, Robin Roberts, et al. Dynamic contrast-enhanced MRI measurements of passive permeability through blood retinal barrier in diabetic rats. Investigative Ophthalmology & Visual Science, 2004, 7(45): 2391-2398.
[18]
Trick GL, Liggett J, Levy J, et al. Dynamic contrast enhanced MRI in patients with diabetic macular edema: initial results. Experimental Eye Research, 2005, 81(1): 97-102.
[19]
Xu Z, Zeng W, Sun JY, et al. The quantification of blood-brain barrier disruption using dynamic contrast-enhanced magnetic resonance imaging in aging rhesus monkeys with spontaneous type 2 diabetes mellitus. Neuroimage, 2016 DOI: 10.1016/j.neuroimage.2016.07.017.
[20]
Ferré JC, Bannier E, Raoult H, et al. Arterial spin labeling (ASL) perfusion: techniques and clinical use. Diagn Interv Imaging, 2013, 94(12): 1211-1223.
[21]
Petcharunpaisan S, Ramalho J, Castillo M. Arterial spin labeling in neuroimaging. World J Radiol, 2010, 2(10): 384-398.
[22]
Van Golen LW, Kuijer JP, Huisman MC, et al. Quantification of cerebral blood flow in healthy volunteers and type 1 diabetic patients: comparison of MRI arterial spin labeling and [(15)O]H2O positron emission tomography (PET). J Magn Reson Imaging, 2014, 40(6): 1300-1309.
[23]
Last D, Alsop DC, Abduljalil AM, et al. Global and regional effects of type 2 diabetes on brain tissue volumes and cerebral vasoreactivity. Diabetes Care, 2007, 30(5): 1193-1199.
[24]
Mangia S, Tesfaye N, De Martino F, et al. Hypoglycemia-induced increases in thalamic cerebral blood flow are blunted in subjects with type 1 diabetes and hypoglycemia unawareness. J Cereb Blood Flow Metab, 2012, 32(11): 2084-2090.
[25]
Zuloaga KL, Johnson LA, Roese NE, et al. High fat diet-induced diabetes in mice exacerbates cognitive deficit due to chronic hypoperfusion. J Cereb Blood Flow Metab, 2016, 36(7): 1257-1270.
[26]
Chung CC, Pimentel D, Jor'dan AJ, et al. Inflammation-associated declines in cerebral vasoreactivity and cognition in type 2 diabetes. Neurology, 2015, 85(5): 450-458.
[27]
Xia W, Rao H, Spaeth AM, et al. Blood pressure is associated with cerebral blood flow alterations in patients with T2DM as revealed by perfusion functional MRI. Medicine (Baltimore), 2015, 94(48): e2231.
[28]
Cui Y, Liang X, Gu H, et al. Cerebral perfusion alterations in type 2 diabetes and its relation to insulin resistance and cognitive dysfunction. Brain Imaging Behav, 2016 DOI: .
[29]
Hoscheidt SM, Kellawan JM, Berman SE, et al. Insulin resistance is associated with lower arterial blood flow and reduced cortical perfusion in cognitively asymptomatic middle-aged adults. Journal of Cerebral Blood Flow & Metabolism, 2016 DOI: .
[30]
Ryan JP, Sheu LK, Verstynen TD, et al. Cerebral blood flow links insulin resistance and baroreflex sensitivity. PLoS One, 2013, 8(12): e83288.
[31]
Rusinek H, Ha J, Yau PL, et al. Cerebral perfusion in insulin resistance and type 2 diabetes. J Cereb Blood Flow Metab, 2015, 35(1): 95-102.
[32]
Novak V, Milberg W, Hao Y, et al. Enhancement of vasoreactivity and cognition by intranasal insulin in type 2 diabetes. Diabetes Care, 2014, 37(3): 751-759.
[33]
王蕾，李斌，谢晟，等. 3.0 T磁共振脑转移瘤IVIM与MR灌注加权成像的相关性研究．医学影像学杂志, 2014, 3(24): 337-341.
[34]
Ze W, Geoffrey A, Hengyi R, et al. Detre, empirical ASL data analysis using an ASL data processing toolbox: ASLtbx. Magnetic Resonance Imaging, 2008, 26(2): 261-269.

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