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• Breast MRI •
The study on the application value of DKI in the classification of invasive breast carcinoma and its correlation with prognostic factors
CHENG Fang  SUO Shi-teng  KANG Ji-wen  HUA Xiao-lan  GENG Xiao-chuan  ZHANG Ke-bei  ZHANG Qing  HUA Jia 

DOI:10.12015/issn.1674-8034.2017.03.002.


[Abstract] Objective: To evaluate the application value of diffusion kurtosis imaging (DKI) based MD, MK parameters in grading invasive breast carcinoma and compare their diagnostic potential.Materials and Methods: Collecting 53 patients with invasive breast carcinoma diagnosed by pathological examination in this study. One male patient and 52 female patients were included. All patients underwent breast magnetic resonance imaging, including traditional magnetic resonance imaging and diffusion kurtosis imaging. ADC, MK and MD were calculated by using post-processing software, Matlab 2011b. Compared with histological grade, the classification of invasive breast carcinoma and its correlation with prognostic factors were statistically analyzed.Results: ADC, MD and MK values have no significant difference in well, moderately and poorly differentiated invasive breast carcinoma (P>0.05). Only ADC and MD were significantly different in ER expression (P<0.05). ADC, MD and MK values showed no significant difference in PR, HER-2 and Ki-67 expression (P>0.05, P=0.055 with MK in Ki-67).Conclusions: DKI has limited value in the evaluation on the classification of invasive breast carcinoma. However it provides useful information in the assessment of tumor proliferation activity.
[Keywords] Breast neoplasms；Magnetic resonance imaging；Pathology, clinical

CHENG Fang Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

SUO Shi-teng Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

KANG Ji-wen Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

HUA Xiao-lan Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

GENG Xiao-chuan Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

ZHANG Ke-bei Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

ZHANG Qing Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

HUA Jia* Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

*Correspondence to: Hua J, E-mail: Jill_huajia@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This study was funded by the Multidisciplinary Cross-program Development Fund Project No. YG2014ZD05
Received  2016-12-16
Accepted  2017-01-20
DOI: 10.12015/issn.1674-8034.2017.03.002
DOI:10.12015/issn.1674-8034.2017.03.002.

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