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• Breast MRI •
The feasibility of intravoxel incoherent motion to indicate immunohistochemical characteristics in breast cancer
SONG Meng-meng  ZHANG Tian-yue  WANG Li-jun  LUO Ran  WANG Deng-bin 

DOI:10.12015/issn.1674-8034.2017.03.003.


[Abstract] Objective: To explore the difference in apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) parameters (D, D*, and f) of breast cancer regarding the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and antigen identified by monoclonal antibody Ki-67.Materials and Methods: Patients suspected to be suffering from breast cancer and had undergone preoperative breast MRI with intravoxel incoherent motion diffusion-weighted imaging in our institution between November 2015 and February 2016 were included in this study. All MR imaging examinations were performed on a 3.0 T MRI scanner (Philips, Ingenia). The ADC values were calculated from DW images at all b-values, assuming monoexponential signal shape. IVIM parameters (D, D*, and f) were obtained using multi-b-value DWI with a biexponential curve fitting. ADC and IVIM parameters (D, D*, and f) of patients with different ER, PR, HER-2, or Ki-67 expression were compared to explore the relationships between MRI and immunohistochemical findings of patients with breast cancer.Results: Fifty-five breast cancer lesions (51 patients) with positive pathologic results were included in our study. Of the 55 lesions, the amount of ER positive, PR positive, HER-2 positive, and Ki-67 high-expression lesions were 45, 40, 14, and 36, respectively. Mean D values in the Ki-67 high-expression group were significantly lower than those in the Ki-67 low-expression group (0.80±0.16 vs 0.88±0.14, P=0.046), while no significant differences were showed in ADC, D*, and f value between the two groups. No statistical significance was reached regarding the difference in mean ADC value or IVIM parameters (D, D*, and f) between the groups with different ER, PR, or HER-2 expression.Conclusions: Statistical difference in D value of IVIM parameters was found between the two groups with different Ki-67 expression in breast carcinoma. This may indicate the potential to provide a surrogate measure of Ki-67 expression through noninvasive imaging tools.
[Keywords] Breast neoplasms；Magnetic resonance imaging；Immunohistochemistry

SONG Meng-meng Department of Radiology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China

ZHANG Tian-yue Department of Radiology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China

WANG Li-jun Department of Radiology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China

LUO Ran Department of Radiology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China

WANG Deng-bin* Department of Radiology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China

*Correspondence to: Wang DB, E-mail: dbwang8@aliyun.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by the fund of National Natural Science Foundation of China No. 81371621 and Shanghai Shenkang Hospital Development Center No. 22015022
Received  2016-12-15
Accepted  2017-01-20
DOI: 10.12015/issn.1674-8034.2017.03.003
DOI:10.12015/issn.1674-8034.2017.03.003.

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