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• Breast MRI •
Comparison of DWI IVIM model and mono-exponential model in evaluating the response of neoadjuvant chemotherapy for breast cancer
GENG Xiao-chuan  ZHANG Qing  HUA Jia  CHAI Wei-ming  SUO Shi-teng  CHENG Fang  ZHANG Ke-bei  CHEN Jie 

DOI:10.12015/issn.1674-8034.2017.03.004.


[Abstract] Objective: To analyze the value of intravoxel incoherent motion (IVIM) model and DWI mono-exponential model in evaluating the response of neoadjuvant chemotherapy (NAC) for breast cancer by comparing the parameters of two models.Materials and Methods: Thirty patients confirmed breast cancer by needle biopsy who received NAC were enrolled in the study. The patients were divided into responders (n=19) and nonresponders (n=11) according to the pathological classification of Miller & Payne. ADC, Ds, Df, f and MR imaging data of patients before, after 2 and 4 cycles of NAC were analyzed retrospectively. Two independent samples t test were used to compare the parameters between the responder and nonresponders. The diagnostic efficacy of different parameters was analyzed by receiver operating characteristics (ROC) curves. The paired samples t test was used to compare the parameters after 2, 4 cycles of NAC to parameters before NAC respectively.Results: ADC and Ds before NAC were significantly higher in responders than those in the nonresponders; the sensitivity and specificity of ADC and Ds were about the same. ADC after 2 cycles of NAC was significantly higher than that before NAC Ds after 2 and 4 cycles of NAC was significantly lower than that before NAC. f after 4 cycles of NAC was significantly lower than that before NAC.Conclusions: ADC value and Ds value are helpful to predict the response to NAC before treatment, and ADC value and Ds value are equivalent in predicting the response of NAC. During the NAC course, ADC, Ds and f values play a certain role in predicting the response of NAC. Mono-exponential model is a better method to evaluate the response of NAC in breast cancer.
[Keywords] Diffusion magnetic resonance imaging；Breast neoplasms；Neoadjuvant chemotherapy

GENG Xiao-chuan Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China

ZHANG Qing Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China

HUA Jia Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China

CHAI Wei-ming Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China

SUO Shi-teng Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China

CHENG Fang Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China

ZHANG Ke-bei Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China

CHEN Jie* Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China

*Correspondence to: Chen J, E-mail: cjpure@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This study was funded by the Multidisciplinary Cross-program Development Fund Project No. YG2014ZD05
Received  2016-12-16
Accepted  2017-01-09
DOI: 10.12015/issn.1674-8034.2017.03.004
DOI:10.12015/issn.1674-8034.2017.03.004.

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