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• Clinical Article •
A fMRI study on the amplitude of low-frequency fluctuation and functional connectivity in resting-state of sensorimotor network of primary hyperthyroidism individuals
YANG Nan  REN Lei  DING Hao  XIAO Qian  SUN Zhi-hua 

DOI:10.12015/issn.1674-8034.2017.03.008.


[Abstract] Objective: To investigate the changes of ALFF (amplitude of low-frequency fluctuation) and FC (functional connectivity) in hyperthyroid patients with RS-fMRI (resting-state functional magnetic resonance imaging), and the relationships of the characteristics with emotional disorders, spontaneous brain resting activities, biochemical and biological characteristics.Materials and Methods: Twelve patients diagnosed with primary hyperthyroidism were collected in this study. Another 12 age-and-sex-matched healthy individuals served as control. Gathering fMRI scaned of all the subjects at their resting-state, using REST and DPARSF software to obtain each amplitude of low-frequency fluctuation (ALFF), then we used two sample t-test to discover the brain areas with significant differentiation of ALFF values. The brain areas were defined as regions of interest (ROI). ROI based functional connectivities (FC) were analyzed to explore some possible abnormalities.Results: Compared with controls, the ALFF of hyperthyroidism individuals was reduced in the bilateral caudate, and bilateral thalamus (P<0.001). In these brain regions, we find no correlation between ALFF and T3, T4 (P>0.05). In contrast with controls, hyperthyroid patients showed stronger FC between the left thalamus and both the bilateral precentral gyrus and bilateral postcentral gyrus (P<0.001), as well as between the right thalamus and both the right precentral gyrus and right postcentral gyrus (P<0.001).Conclusions: The present study shows that, functional demands between bilateral thalamus and sensorimotor network are higher in patients compared to controls. It is likely attributed to motor function deficit associated with metabolic impairment in these patients.
[Keywords] Hyperthyroidism；Magnetic resonance imaging；Sensorimotor network；Amplitude of low frequency fluctuation；Functional connectivity

YANG Nan Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China

REN Lei Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China

DING Hao Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China

XIAO Qian Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China

SUN Zhi-hua* Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China

*Correspondence to: Sun ZH, E-mail: dr_zhihuasun@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by the National Natural Science Foundation of China No. 81201152
Received  2016-11-07
Accepted  2017-01-06
DOI: 10.12015/issn.1674-8034.2017.03.008
DOI:10.12015/issn.1674-8034.2017.03.008.

[1]
张利红，张玲，黎海涛，等．甲状腺功能亢进伴精神神经症状患者脑功能区研究．第三军医大学学报, 2013, 35(23): 2573-2576.
[2]
Zhang Y, Zhang BC, Xu J, et al. Thyroxine therapy ameliorates serum levels of eicosanoids in Chinese subclinical hypothyroidism patients. Acta Pharmacol Sin, 2016, 37(5): 656-663.
[3]
Fahrenfort JJ, Wilterdink AM, van der Veen EA. Long-term residual complaints and psychosocial sequelae after remission of hyperthyroidism. Psychoneuroendocrinology, 2000, 25(2): 201-211.
[4]
Grigoryeva EA, Pavlova EA. A comparative hormonal and clinical analysis of thyrotoxicosis with- or without comorbid resistant depression. Zh Nevrol Psikhiatr Im S S Korsakova, 2015, 115(6): 12-16.
[5]
Ittermann T, Volzke H, Baumeister SE, et al. Diagnosed thyroid disorders are associated with depression and anxiety. Soc Psychiatry Psychiatr Epidemiol, 2015, 50(9): 1417-1425.
[6]
Flamant F, Koibuchi N, Bernal J. Editorial: "Thyroid Hormone in Brain and Brain Cells". Front Endocrinol (Lausanne), 2015, 6: 99.
[7]
Bauer M, Goetz T, Glenn T, et al. The thyroid-brain interaction in thyroid disorders and mood disorders. J Neuroendocrinol, 2008, 20(10): 1101-1114.
[8]
Kung AW. Neuromuscular complications of thyrotoxicosis. Clin Endocrinol (Oxf), 2007, 67(5): 645-650.
[9]
Zhang W, Song L, Yin X, et al. Grey matter abnormalities in untreated hyperthyroidism: a voxel-based morphometry study using the DARTEL approach. Eur J Radiol, 2014, 83(1): e43-e48.
[10]
Singh S, Trivedi R, Singh K, et al. Diffusion tensor tractography in hypothyroidism and its correlation with memory function. J Neuroendocrinol, 2014, 26(11): 825-833.
[11]
Sagiyama K, Watanabe Y, Nishie A, et al. Recent advances in MR imaging for cancer diagnosis. Gan To Kagaku Ryoho, 2015, 42(3): 257-260.
[12]
Zang YF, He Y, Zhu CZ, et al. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Dev, 2007, 29(2): 83-91.
[13]
Biswal B, Zerrin Yetkin F, Haughton VM, et al. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med, 1995, 34(4): 537-541.
[14]
刘会茹，王维卓，王欣，等．脑梗死运动性失语患者的静息态脑功能研究．医学影像学杂志, 2014(10): 1674-1679.
[15]
Wise RA. Roles for nigrostriatal-not just mesocorticolimbic-dopamine in reward and addiction. Trends Neurosci, 2009, 32(10): 517-524.
[16]
周波，张增强，安宁豫，等．静息态功能磁共振观察阿尔茨海默病患者丘脑功能连接特点．中华神经科杂志, 2013, 46(1): 10-16.
[17]
Alexander GE, Delong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci, 1986, 9(9): 357-381.
[18]
Khushu S, Kumaran SS, Sekhri T, et al. Cortical activation during finger tapping in thyroid dysfunction: a functional magnetic resonance imaging study. J Biosci, 2006, 31(5): 543-550.
[19]
Veldman MP, Zijdewind I, Maffiuletti NA, et al. Motor skill acquisition and retention after somatosensory electrical stimulation in healthy humans. Front Hum Neurosci, 2016, 10: 115.
[20]
Zhang W, Liu X, Zhang Y, et al. Disrupted functional connectivity of the hippocampus in patients with hyperthyroidism: evidence from resting-state fMRI. Eur J Radiol, 2014, 83(10): 1907-1913.
[21]
Gottlich M, Heldmann M, Gobel A, et al. Experimentally induced thyrotoxicosis leads to increased connectivity in temporal lobe structures: a resting state fMRI study. Psychoneuroendocrinology, 2015, 56: 100-109.
[22]
Singh S, Kumar M, Modi S, et al. Alterations of functional connectivity among resting-state networks in hypothyroidism. J Neuroendocrinol, 2015, 27(7): 609-615.
[23]
Zhu DF, Wang ZX, Zhang DR, et al. fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism. Brain, 2006, 129(Pt 11): 2923-2930.
[24]
潘仲林，朱德发，朱友志，等．利用fMRI评价亚临床甲状腺功能减退症患者工作记忆损伤．医学影像学杂志, 2010, (8): 1092-1097.
[25]
Blasi V, Longaretti R, Giovanettoni C, et al. Decreased parietal cortex activity during mental rotation in children with congenital hypothyroidism. Neuroendocrinology, 2009, 89(1): 56-65.

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