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• Original Article •
Experimental study on DWI in identifying ischemic renal impairment and dysfunction in rats
YANG Chao-wu  HE Guang-wu  ZHAO Bing-hui 

DOI:10.12015/issn.1674-8034.2017.03.012.


[Abstract] Objective: To investigate diffusion weighted imaging (DWI) in evaluating renal impairment and dysfunction in rats due to unilateral renal arterial stenosis (RAS), contrast to 99Tcm-DTPA SPECT Renograhy and pathology.Materials and Methods: The model of the unilateral left RAS was created in twenty-four rats according to the approved protocol. The renal impairment and dysfunction were subsequently measured by 99Tcm-DTPA SPECT based on the glomerular filtration rate (GFR), DWI based on the apparent diffusion coefficient (ADC) value after two, three and four weeks. The b value of DWI was scanned under the 0 s/mm2, 800 s/mm2, 1200 s/mm2 and 1500 s/mm2 respectively. As well the average values of ADC of the renal medulla and cortex parenchyma were calculated respectively and compared. The relationship between GFR and the imaging based on 99Tcm-DTPA SPECT were detected. The Spearman's correlation test and the paired-samples t test were adopted in statistics.Results: The values of ADC of renal parenchyma (ROI including medulla and cortex) had a significant positive correlation with GFR (P=0.001, r=0.584). The values of ADC of the cortical and medulla were significant different between the two kidneys (cortex: t=4.626, P=0.001; medulla: t=2.699, P=0.019).Conclusions: The DWI based on ADC is significant to evaluate the renal impairment and dysfunction, which is helpful to detect the late period of renal ischemic injury and reduce the renal injury caused by contrast agent.
[Keywords] Ischemic renal injury；Renal insufficiency；Magnetic resonance imaging

YANG Chao-wu Department of Radiology, Baoshan Branch of Shanghai First People's Hospital, Shanghai 200940, China

HE Guang-wu Department of Radiology, Baoshan Branch of Shanghai First People's Hospital, Shanghai 200940, China

ZHAO Bing-hui* Department of Radiology, Shanghai Tenth People's Hospital, Shanghai 200072, China

*Correspondence to: Zhao BH, E-mail: binghuizhao@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This research is supported by the Baoshan District healthy youth medical talents training program in Shanghai No. bswsyq-2016a05
Received  2016-10-10
Accepted  2017-01-08
DOI: 10.12015/issn.1674-8034.2017.03.012
DOI:10.12015/issn.1674-8034.2017.03.012.

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