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• IVIM Papers •
The predictive value of IVIM-DWI on short-term therapeutic effect and prognosis of TACE on hepatocellular carcinoma
MA Xiao-hong  WANG Shuang  ZHAO Xin-ming  WANG Qian  ZHU Yong-jian  OUYANG Han  ZHOU Chun-wu 

DOI:10.12015/issn.1674-8034.2017.04.003.


[Abstract] Objective: To investigate the postoperative early response and short-term prognosis value of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) quantitative parameters for the patients with hepatocellular carcinoma (HCC) treated by transcatheter arterial chemoembolization (TACE).Materials and Methods: Ninety patients with biopsy-proven or clinical diagnostic HCC underwent IVIM-DWI on a 3.0 T MR scanner before TACE, and 90 HCC patients took the same MR scan one month after TACE. The quantitative parameters were measured on the maximal tumor region, including D, D* and f value before and after TACE. The patients were divided into progress group and stable group based on mRECIST as criterion. All data were statistically analyzed.Results: There were significant differences between progress group and the stable group in D and D* values of the tumor before TACE (P<0.05, respectively). One month after TACE, the ΔD and ΔD* values of the tumor had significant differences between the two groups (P<0.05, respectively). The D and D* values of tumors had significant differences before and after TACE (P<0.05, respectively).Conclusion: The D, D* values of the IVIM-DWI could predict the efficacy before TACE in HCC patients. Furthermore, the IVIM-DWI as a noninvasive method might evaluate the early response after TACE in HCC patients.
[Keywords] Liver neoplasms；Magnetic resonance imaging；Diffusion-weighted imaging；Intravoxel incoherent motion；Hepatic artery；Embolization, therapeutic

MA Xiao-hong Department of Diagnostic, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

WANG Shuang Department of Diagnostic, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

ZHAO Xin-ming Department of Diagnostic, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

WANG Qian Department of Diagnostic, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

ZHU Yong-jian Department of Diagnostic, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

OUYANG Han Department of Diagnostic, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

ZHOU Chun-wu* Department of Diagnostic, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

*Correspondence to: Zhou CW, E-mail: cjr.zhouchunwu@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Public Welfare Scientific Research Project of Chinese Academy of Medical Sciences No. 201402019 Beijing Hope Run Special Fund of Cancer Foundation of China No. LC2016B15
Received  2016-12-14
Accepted  2017-02-21
DOI: 10.12015/issn.1674-8034.2017.04.003
DOI:10.12015/issn.1674-8034.2017.04.003.

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