Share：
Share this content in WeChat
X
[Chinese][PDF]71897
• IVIM Papers •
Intravoxel incoherent motion magnetic resonance imaging for evaluating the efficacy of concurrent chemoradiotherapy in nasopharyngeal carcinoma
GUO Ting-ting  LIU Song  ZHOU Nan  ZHOU Zheng-yang 

DOI:10.12015/issn.1674-8034.2017.04.004.


[Abstract] Objective: To explore the value of intravoxel incoherent motion magnetic resonance imaging in evaluating the efficacy of chemoradiotherapy in nasopharyngeal carcinoma (NPC).Materials and Methods: Twenty-seven patients with nasopharyngeal carcinoma proved by biopsy pathology were enrolled. Those patients underwent MRI at the time points of pretreatment (group 1), one month after the start of radiotherapy (group 2) and one month after the end of radiotherapy (group 3). T1WI, T2WI, IVIM (9 b-factors, 0~800 s/mm2) and contrast-enhanced T1WI were included. They received concurrent chemotherapy for 3 cycles during radiotherapy. The apparent diffusion coefficient (ADC) was derived from the mono-exponential model, while the diffusion coefficient (D), perfusion fraction (f) and pseudodiffusion coefficient (D*) were calculated via the bi-exponential model. The values of IVIM parameters and maximum area for NPC lesions were measured at each time point, and their dynamic changes and correlation were analyzed.Results: Patients whose images had artifact were excluded, and 23 patients were included in this study finally. The ADC and D values increased throughout the whole course. ADC value of group 1 and 3 was 0.80×10-3 mm2/s and 1.57×10-3 mm2/s, respectively (P1/3<0.001); D value of group 1 and 3 was 0.68×10-3 mm2/s and 1.31×10-3 mm2/s, respectively (P1/3<0.001). f value was increased originally then decreased. f value of group 1 and 2 was 11% and 19% (P1/2<0.001). There were no correlations between group 1 and group 2, group 1 and group 3, group 2 and group 3 for D* value.Conclusion: IVIM-MRI could monitor dynamic changes of NPC during treatment. ADC value was influenced by microcirculation perfusion, therefore the diffusion of water molecules were overrated. D value was calculated from high b values (>200 s/mm2), so microcirculation perfusion had little effect on MR signal, it reflected pure diffusion information. D value was better at monitoring the efficacy of chemoradiotherapy. f value might be a potential biomarker.
[Keywords] Intravoxel incoherent motion；Nasopharyngeal neoplasms；Chemoradiotherapy；Magnetic resonance imaging

GUO Ting-ting Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China

LIU Song Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China

ZHOU Nan Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China

ZHOU Zheng-yang* Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China

*Correspondence to: Zhou ZY, E-mail: zyzhou@nju.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No.81371516 Foundation of National Health and Family Planning Commission No.W201306
Received  2017-01-10
Accepted  2017-03-22
DOI: 10.12015/issn.1674-8034.2017.04.004
DOI:10.12015/issn.1674-8034.2017.04.004.

[1]
Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin, 2015, 65(2): 87-108.
[2]
Zhu L, Zhu L, Shi H, et al. Evaluating early response of cervical cancer under concurrent chemo-radiotherapy by intravoxel incoherent motion MR imaging. BMC Cancer, 2016, 16(1): 1-8.
[3]
Ganten MK, Schuessler M, Bauerle T, et al. The role of perfusion effects in monitoring of chemoradiotherapy of rectal carcinoma using diffusion-weighted imaging. Cancer Imaging, 2013, 13(4): 548-556.
[4]
Le BD, Breton E, Lallemand D, et al. Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology, 1988, 168(2): 497-505.
[5]
Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer, 2009, 45(2): 228-247.
[6]
Jia QJ, Zhang SX, Chen WB, et al. Initial experience of correlating parameters of intravoxel incoherent motion and dynamic contrast-enhanced magnetic resonance imaging at 3.0 T in nasopharyngeal carcinoma. Eur Radiol, 2014, 24(12): 3076-3087.
[7]
Hatakenaka M, Nakamura K, Yabuuchi H, et al. Pretreatment apparent diffusion coefficient of the primary lesion correlates with local failure in head-and-neck cancer treated with chemoradiotherapy or radiotherapy. Int J Radiat Oncol Biol Phys, 2011, 81(2): 339-345.
[8]
Xiao Y, Pan J, Chen Y, et al. Intravoxel incoherent motion-magnetic resonance imaging as an early predictor of treatment response to neoadjuvant chemotherapy in locoregionally advanced nasopharyngeal carcinoma. Medicine(Baltimore), 2015, 94(24): 973.
[9]
王欢欢，周正扬，朱丽晶，等. IVIMMRI评估宫颈癌同步放化疗疗效探讨．中华放射肿瘤学杂志, 2016, 25(10): 1100-1105.
[10]
Hauser T, Essig M, Jensen A, et al. Characterization and therapy monitoring of head and neck carcinomas using diffusion-imaging-based intravoxel incoherent motion parameters-preliminary results. Neuroradiology, 2013, 55(5): 527-536.
[11]
Hou J, Yu X, Hu Y, et al. Value of intravoxel incoherent motion and dynamic contrast-enhanced MRI for predicting the early and short-term responses to chemoradiotherapy in nasopharyngeal carcinoma. Medicine (Baltimore), 2016, 95(35): 4320.
[12]
Sumi M, Van Cauteren M, Sumi T, et al. Salivary gland tumors: use of intravoxel incoherent motion MR imaging for assessment of diffusion and perfusion for the differentiation of benign from malignant tumors. Radiology, 2012, 263(3): 770-777.
[13]
Federau C, Hagmann P, Maeder P, et al. Dependence of brain intravoxel incoherent motion perfusion parameters on the cardiac cycle. PLoS One, 2013, 8(8): 72856.
[14]
Kakite S, Dyvorne H, Besa C, et al. Hepatocellular carcinoma: short-term reproducibility of apparent diffusion coefficient and intravoxel incoherent motion parameters at 3.0 T. J Magn Reson Imaging, 2015, 41(1): 149-156.

PREV The predictive value of IVIM-DWI on short-term therapeutic effect and prognosis of TACE on hepatocellular carcinoma
NEXT Application of introvoxel incoherent motion sequence in the preoperative T-stage of tongue carcinoma
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn