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• Clinical Article •
Reduced perfusion in normal appearing white matter in relapsing-remitting multiple sclerosis using 3D pseudocontinuous arterial spin labeling
MA Xiao-xiao  LV Jin-hao  TANG Jing  HUANG De-hui  MA Lin  LOU Xin 

DOI:10.12015/issn.1674-8034.2017.04.007.


[Abstract] Objective: To investigate whether cerebral blood flow (CBF) is abnormal in normal appearing white matter (NAWM) using 3D pseudocontinuous arterial spin labeling (3D pCASL) and its relationship with clinical data.Materials and Methods: Twenty-nine relapsing-remitting MS (RRMS) and seventeen age, sex-matched healthy control subjects were prospectively and consecutively enrolled and performed MRI including T2 weighted image (T2WI), 3-dimensional Fast Spoiled Gradient Echo (3D FSPGR) and 3D pCASL. Regions of interest (ROIs) in centrum semiovale and periventricular NAWM were manually outlined to obtain the average CBF values. Two independent samples t-test was conducted for comparisons between RRMS and healthy control group in centrum semiovale and periventricular NAWM. Person and Spearman correlation analysis were used to assess the relation between clinical data and CBF values for RRMS group.Results: Compared to healthy control subjects, CBF values were significantly reduced both in centrum semiovale and periventricular NAWM in RRMS (centrum semiovale NAWM: 32.5452±4.5848 vs 35.4865±5.7968, P=0.036; periventricular NAWM: 30.7788±4.1746 vs 34.0530±4.4821, P=0.006). In RRMS group, no relationships were found between CBF values and clinical data (age, age of first onset, onset frequency, disease duration and EDSS score).Conclusion: Our 3D pCASL results showed reduced perfusion in NAWM in RRMS group indicating that there exists potential hemodynamic abnormality in NAWM and hemodynamics may be play a pivotal role in pathogenesis of RRMS patients.
[Keywords] Multiple sclerosis, relapsing-remitting；Leukoencephalopathies；Arterial spin labeling；Cerebral blood flow；Magnetic resonance imaging

MA Xiao-xiao Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

LV Jin-hao Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

TANG Jing Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

HUANG De-hui Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China

MA Lin Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

LOU Xin* Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

*Correspondence to: Lou X, E-mail: louxin301@gmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Funds No.81671126 National Key Research and Development Program No.2016YF C01001004
Received  2017-01-06
Accepted  2017-03-22
DOI: 10.12015/issn.1674-8034.2017.04.007
DOI:10.12015/issn.1674-8034.2017.04.007.

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