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• Clinical Article •
Cerebro-cerebellar functional connectivity in patients with generalized tonic-clonic seizure: a resting state functional MRI study
MU Ying  ZHANG Zhe  LIU Guang-yao  LIU Hong  ZHANG Jing  FAN Zhenyu 

DOI:10.12015/issn.1674-8034.2017.04.010.


[Abstract] Objective: To explore the altered features of cerebro-cerebellar functional connectivity in resting-state during the interictal time of generalized tonic-clonic seizure (GTCS).Materials and Methods: Nineteen patients with GTCS and 22 age-, sex-, education- and handedness-matched healthy controls (HCs) were recruited. All the individuals' resting-state fMRI data were acquired in a Siemens 3.0 T MR. Firstly, amplitude of low-frequency fluctuations (ALFF) was applied to investigate the changes of whole brain spontaneous functional activity caused by GTCS. Then resting-state functional connectivity (rsFC) was calculated between seeds regions based on ALFF group differences in cerebrum (cerebellum) and all voxels in cerebellum (cerebrum). Finally, the correlation analysis was performed between ALFF/rsFC and NHS3 scores in brain regions with significant group differences.Results: Compared with the HCs, the patients with GTCS exhibit significantly increased ALFF in the right hippocampus, right cerebellar_crus2 and left cerebellar_4_5, but significantly decreased in the right precuneus and left middle frontal gyrus. Seed-based rsFC analysis showed that rsFC in patients with GTCS was significantly increased in the left cerebellar_8, right cerebellar_4_5, and right cerebellar_4_5, but significantly decreased in the left inferior frontal gyrus and right middle temporal gyrus. Furthermore, correlation analysis exhibit the positively correlated between NHS3 scores and rsFC of the left cerebellar_8 (r=0.48, P=0.036) in patients with GTCS, but negatively correlated between NHS3 scores and rsFC of the right middle temporal gyrus (r=-0.34, P=0.042) in patients with GTCS.Conclusion: Cerebro-cerebellar resting-state functional connectivity was abnormal during the interictal time of GTCS, which may be associated with the pathophysiological mechanism and clinical manifestations in patients with GTCS.
[Keywords] Epilepsy, tonic-clonic；Amplitude of low-frequency fluctuations；Cerebellum；Functional connectivity；Magnetic resonance imaging, functional

MU Ying Department of Electronics and Information Engineering, Lanzhou Institute of Technology, Lanzhou 730050, China

ZHANG Zhe Department of Electronics and Information Engineering, Lanzhou Institute of Technology, Lanzhou 730050, China

LIU Guang-yao* Department of MR, Lanzhou University Second Hospital, Lanzhou 730030, China

LIU Hong Department of MR, Lanzhou University Second Hospital, Lanzhou 730030, China

ZHANG Jing Department of MR, Lanzhou University Second Hospital, Lanzhou 730030, China

FAN Zhenyu The Epilepsy Center of Lanzhou University Second Hospital, Lanzhou 730030, China

*Correspondence to: Liu GY, Email: lgy362263779@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Gansu Province Natural Science Foundation No.1506RJYA218 The Scientific Innovation Foundation of Lanzhou Institute of Technology No.2014K-007
Received  2016-12-31
Accepted  2017-02-21
DOI: 10.12015/issn.1674-8034.2017.04.010
DOI:10.12015/issn.1674-8034.2017.04.010.

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