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• Clinical Article •
Cerebro-cerebellar functional connectivity in patients with generalized tonic-clonic seizure: a resting state functional MRI study
MU Ying  ZHANG Zhe  LIU Guang-yao  LIU Hong  ZHANG Jing  FAN Zhenyu 

DOI:10.12015/issn.1674-8034.2017.04.010.


[Abstract] Objective: To explore the altered features of cerebro-cerebellar functional connectivity in resting-state during the interictal time of generalized tonic-clonic seizure (GTCS).Materials and Methods: Nineteen patients with GTCS and 22 age-, sex-, education- and handedness-matched healthy controls (HCs) were recruited. All the individuals' resting-state fMRI data were acquired in a Siemens 3.0 T MR. Firstly, amplitude of low-frequency fluctuations (ALFF) was applied to investigate the changes of whole brain spontaneous functional activity caused by GTCS. Then resting-state functional connectivity (rsFC) was calculated between seeds regions based on ALFF group differences in cerebrum (cerebellum) and all voxels in cerebellum (cerebrum). Finally, the correlation analysis was performed between ALFF/rsFC and NHS3 scores in brain regions with significant group differences.Results: Compared with the HCs, the patients with GTCS exhibit significantly increased ALFF in the right hippocampus, right cerebellar_crus2 and left cerebellar_4_5, but significantly decreased in the right precuneus and left middle frontal gyrus. Seed-based rsFC analysis showed that rsFC in patients with GTCS was significantly increased in the left cerebellar_8, right cerebellar_4_5, and right cerebellar_4_5, but significantly decreased in the left inferior frontal gyrus and right middle temporal gyrus. Furthermore, correlation analysis exhibit the positively correlated between NHS3 scores and rsFC of the left cerebellar_8 (r=0.48, P=0.036) in patients with GTCS, but negatively correlated between NHS3 scores and rsFC of the right middle temporal gyrus (r=-0.34, P=0.042) in patients with GTCS.Conclusion: Cerebro-cerebellar resting-state functional connectivity was abnormal during the interictal time of GTCS, which may be associated with the pathophysiological mechanism and clinical manifestations in patients with GTCS.
[Keywords] Epilepsy, tonic-clonic；Amplitude of low-frequency fluctuations；Cerebellum；Functional connectivity；Magnetic resonance imaging, functional

MU Ying Department of Electronics and Information Engineering, Lanzhou Institute of Technology, Lanzhou 730050, China

ZHANG Zhe Department of Electronics and Information Engineering, Lanzhou Institute of Technology, Lanzhou 730050, China

LIU Guang-yao* Department of MR, Lanzhou University Second Hospital, Lanzhou 730030, China

LIU Hong Department of MR, Lanzhou University Second Hospital, Lanzhou 730030, China

ZHANG Jing Department of MR, Lanzhou University Second Hospital, Lanzhou 730030, China

FAN Zhenyu The Epilepsy Center of Lanzhou University Second Hospital, Lanzhou 730030, China

*Correspondence to: Liu GY, Email: lgy362263779@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Gansu Province Natural Science Foundation No.1506RJYA218 The Scientific Innovation Foundation of Lanzhou Institute of Technology No.2014K-007
Received  2016-12-31
Accepted  2017-02-21
DOI: 10.12015/issn.1674-8034.2017.04.010
DOI:10.12015/issn.1674-8034.2017.04.010.

[1]
王茂雪，张志强，王正阁，等．全面强直阵挛癫痫发作间期的静息态fMRI低频振幅研究．中国医学影像技术, 2011, 27(10): 1985-1989.
[2]
Stoodley CJ. The cerebellum and cognition: evidence from functional imaging studies. Cerebellum, 2012, 11(2): 352-365.
[3]
刘光耀，杨晓萍，张喆，等．原发性全面强直阵挛癫痫全脑比率低频振幅的静息态fMRI研究．中国临床医学影像杂志, 2013, 24(9): 609-612.
[4]
Zhu L, Li Y, Wang Y, et al. Aberrant long-range functional connectivity density in generalized tonic-clonic seizures. Medicine, 2016, 95(24): 3893.
[5]
Fox MD, Snyder AZ, Vincent JL, et al. The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci USA, 2005, 102(27): 9673-9678.
[6]
Song M, Du H, Wu N, et al. Impaired resting-state functional integrations within default mode network of generalized tonic-clonic seizures epilepsy. PloS one, 2011, 6(2): 17294.
[7]
张喆，柯铭，刘光耀，等．癫痫患者默认网络的静息态功能磁共振成像研究．中国临床心理学杂志, 2013, 21(3): 363-367.
[8]
Wei HL, An J, Zeng LL, et al. Altered functional connectivity among default, attention, and control networks in idiopathic generalized epilepsy. Epilepsy Behav, 2015, 46: 118-125.
[9]
Moeller F, Maneshi M, Pittau F, et al. Functional connectivity in patients with idiopathic generalized epilepsy. Epilepsia, 2011, 52(3): 515-522.
[10]
季公俊，廖伟，张志强，等．全面强直阵挛癫痫静息态功能连接脑网络研究．磁共振成像, 2013, 4(1): 8-12.
[11]
Wang Z, Zhang Z, Liao W, et al. Frequency-dependent amplitude alterations of resting-state spontaneous fluctuations in idiopathic generalized epilepsy. Epilepsy Res, 2014, 108(5): 853-860.
[12]
Kim JB, Suh SI, Seo WK, et al. Altered thalamocortical functional connectivity in idiopathic generalized epilepsy. Epilepsia, 2014, 55(4): 592-600.
[13]
Khan AJ, Nair A, Keown CL, et al. Cerebro-cerebellar resting-state functional connectivity in children and adolescents with autism spectrum disorder. Biol Psychiatry, 2015, 78(9): 625-634.
[14]
Guo W, Liu F, Chen J, et al. Resting-state cerebellar-cerebral networks are differently affected in first-episode, drug-naive schizophrenia patients and unaffected siblings. Sci Rep, 2015(5): 17275.
[15]
Kucyi A, Hove MJ, Biederman J, et al. Disrupted functional connectivity of cerebellar default network areas in attention-deficit/hyperactivity disorder. Hum Brain Mapp, 2015, 36(9): 3373-3386.
[16]
Buckner RL, Krienen FM, Castellanos A, et al. The organization of the human cerebellum estimated by intrinsic functional connectivity. J Neurophysiol, 2011, 106(3): 1125-1165.
[17]
Fox MD, Corbetta M, Snyder AZ, et al. Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems. Proc Natl Acad Sci USA, 2006, 103(26): 10046-10051.
[18]
Long L, Zeng L, Song Y, et al. Altered cerebellar-cerebral functional connectivity in benign adult familial myoclonic epilepsy. Epilepsia, 2016, 57(6): 941-948.

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