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The brain mechanism of experimental itch: a Meta-analysis
ZHONG Hai-li  WU Wen 

DOI:10.12015/issn.1674-8034.2017.04.012.


[Abstract] Objective: For a more comprehensive description of the center network processing of itch, a Meta-analysis of neuroimaging was conducted to evaluate the structures activated during experimental itch status.Materials and Methods: Database search was performed in PubMed, Cochrane's library, Wiley Online Library, Springer Link, Science Direct, EMBASE.com, CNKI and Chinese Biomedical Literature Database for literatures published from database establishment to Aguest 2016. We collected the studies on support from functional magnetic resonance imaging (fMRI) in pruritus status according to inclusion and exclusion criteria. The ALE map was created with Ginger-ALE 2.3.6 software and the images were rendered using Mango.Results: Eight studies were identified with a total of 100 subjects. Our Meta-analysis showed that following the itch stimulation, a positive activation was localized in insular, medial dorsal nucleus of thalamus, claustrum, putamen, anterior cingulate, superior frontal gyrus, posterior cingulate, precuneus inferior frontal gyrus, middle frontal gyrus, postcentral gyrus.Conclusion: By integrating the analysis of previous fMRI studies in itch status, we thought that itching impulses pass to the central nervous system by way of the spinothalamic tract, mainly activating postcentral gyrus, precuneus, insula, cingulate cortex, premotor and supplementary motor area, prefrontal area. These brain regions contribut to the encoding of sensory processing, emotional reactions, motion planning and cognitive-evaluative of pruritus.
[Keywords] Itch；Magnetic resonance imaging, functional；Meta-analysis；Activation likelihood estimation

ZHONG Hai-li Department of Rehabilitation Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China

WU Wen* Department of Rehabilitation Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China

*Correspondence to: Wu W, E-mail: wuwen66@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81473769 Natural Science Foundation of Guangdong No. 2014A030313335
Received  2016-09-09
Accepted  2016-12-19
DOI: 10.12015/issn.1674-8034.2017.04.012
DOI:10.12015/issn.1674-8034.2017.04.012.

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