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• Clinical Article •
The functional connectivity of orbitofrontal cortex in type 2 diabetes: a resting-state fMRI study
CHEN Juan  LIU Jun  LIU Huang-hui  LIU Hua-sheng  DENG Ling-ling  LI Mei-jiao  RONG Peng-fei  WANG Wei 

DOI:10.12015/issn.1674-8034.2017.05.001.


[Abstract] Objective: Our aim was to detect weather the functional connectivity between the orbitofrontal cortex (OFC) and other brain regions were impaired in type 2 diabetes mellitus (T2DM).Materials and Methods: Conventional magnetic resonance imaging (MRI) and blood oxygen level dependent resting-state functional MRI were obtained from 27 diabetic patients without cerebrovascular diseases on imaging, and from 21 age-matched healthy volunteers. The functional connectivity between the bilateral OFC and other voxels of the whole brain was calculated and compared between the two groups. The brain regions with significant differences between the groups were selected, then, the mean value of the functional connectivity between these regions was calculated. The correlations were analyzed with the clinical indexes.Results: Compared to the control group, the patients showed significantly reduced functional connectivity between the posterior of left medial OFC and left midbrain, right hypothalamus and bilateral thalamus. In the patients group, the mean value of functional connectivity between the posterior of left medial OFC and the left midbrain was positively correlated with the value of fasting plasma glucose (t=2.3727, P=0.028).Conclusions: The functional connectivity between the left OFC and multiple brain regions in patients with type 2 diabetes mellitus was impaired, and the reduced functional connectivity value between the left OFC and the left midbrain was significantly associated with the controlling of the plasma glucose, which indicated that type 2 diabetes mellitus may impaire some reward-related pathways, leading to eating disorders.
[Keywords] Diabetes Mellitus, Type 2；Orbitofrontal cortex；Resting-state functional connectivity；Magnetic resonance imaging

CHEN Juan Department of Radiology, the Third Xiangya Hospital of Central South University, Changsha 410013, China

LIU Jun Department of Radiology, the Third Xiangya Hospital of Central South University, Changsha 410013, China

LIU Huang-hui Department of Radiology, the Third Xiangya Hospital of Central South University, Changsha 410013, China

LIU Hua-sheng Department of Radiology, the Third Xiangya Hospital of Central South University, Changsha 410013, China

DENG Ling-ling Department of Radiology, the Third Xiangya Hospital of Central South University, Changsha 410013, China

LI Mei-jiao Department of Radiology, the Third Xiangya Hospital of Central South University, Changsha 410013, China

RONG Peng-fei Department of Radiology, the Third Xiangya Hospital of Central South University, Changsha 410013, China

WANG Wei* Department of Radiology, the Third Xiangya Hospital of Central South University, Changsha 410013, China

*Correspondence to: Wang W, E-mail: cjr.wangwei@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of project of National Key Clinical Specialty No. 2013-544 National Natural Science Foundation of China No. 81471715
Received  2017-01-16
Accepted  2017-03-03
DOI: 10.12015/issn.1674-8034.2017.05.001
DOI:10.12015/issn.1674-8034.2017.05.001.

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