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• Clinical Article •
Feasibility study of hepatobiliary-specific contrast agent Gd- EOB-DTPA-enhanced MRI in evaluating liver function of patients with primary biliary cholangitis
HAN Dan  ZHANG Jie  JIN Er-hu  HE Wen  YANG Zheng-han  WANG Zhen-chang 

DOI:10.12015/issn.1674-8034.2017.05.004.


[Abstract] Objective: To study the feasibility of evaluating the liver function of patients with primary biliary cholangitis (PBC) by hepatocyte-specific contrast agent Gd-EOB-DTPA-enhanced MRI.Materials and Methods: A total of 50 subjects were enrolled in this study, of which 25 were PBC patients (group A), and 25 were other causes of cirrhosis patients (group B). Following intravenous injection of Gd-EOB-DTPA, the average relative signal enhancement (RE) of the liver at 4 min, 20 min and 50 min, and the contrast to noise ratio (CNR) of the common bile duct at 50 min on MRI were measured and calculated. The RE and CNR values between any Child- Pugh classes in group A were compared. The RE of the liver (20 min) and CNR of the common bile duct (50 min) in the same Child-Pugh class were compared between group A and group B.Results: RE of the live at 4 min, 20 min and 50 min, and CNR of the common bile duct at 50 min decreased with an increase of Child-Pugh class of the liver function in group A (P<0.05). No significant difference (P>0.05) was detected between group A and group B in the same Child-Pugh class with respect to RE of the liver (20 min) and CNR of the common bile duct (50 min). This indicated that RE of the live and CNR of the common bile duct could be related mainly to the liver function, and perhaps minimally to the cholestasis and/or excretion dysfunction of intrahepatic small bile ducts.Conclusions: Gd-EOB-DTPA-enhanced MRI may aid in comprehensive assessment of the liver function in patients with PBC.
[Keywords] Magnetic resonance imaging；Gd-EOB-DTPA；Primary biliary cholangitis；Liver function

HAN Dan Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing100050, China

ZHANG Jie Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing100050, China

JIN Er-hu* Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing100050, China

HE Wen* Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing100050, China

YANG Zheng-han Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing100050, China

WANG Zhen-chang Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing100050, China

*Correspondence to: Jin EH, E-mail: erhujin@263.net He W, E-mail: hewen8080@ sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by the Health Industry Special Scientific Research Project No. 201402019
Received  2016-12-26
Accepted  2017-02-26
DOI: 10.12015/issn.1674-8034.2017.05.004
DOI:10.12015/issn.1674-8034.2017.05.004.

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