Share：
Share this content in WeChat
X
[Chinese][PDF]71177
• Clinical Article •
Feasibility study of hepatobiliary-specific contrast agent Gd- EOB-DTPA-enhanced MRI in evaluating liver function of patients with primary biliary cholangitis
HAN Dan  ZHANG Jie  JIN Er-hu  HE Wen  YANG Zheng-han  WANG Zhen-chang 

DOI:10.12015/issn.1674-8034.2017.05.004.


[Abstract] Objective: To study the feasibility of evaluating the liver function of patients with primary biliary cholangitis (PBC) by hepatocyte-specific contrast agent Gd-EOB-DTPA-enhanced MRI.Materials and Methods: A total of 50 subjects were enrolled in this study, of which 25 were PBC patients (group A), and 25 were other causes of cirrhosis patients (group B). Following intravenous injection of Gd-EOB-DTPA, the average relative signal enhancement (RE) of the liver at 4 min, 20 min and 50 min, and the contrast to noise ratio (CNR) of the common bile duct at 50 min on MRI were measured and calculated. The RE and CNR values between any Child- Pugh classes in group A were compared. The RE of the liver (20 min) and CNR of the common bile duct (50 min) in the same Child-Pugh class were compared between group A and group B.Results: RE of the live at 4 min, 20 min and 50 min, and CNR of the common bile duct at 50 min decreased with an increase of Child-Pugh class of the liver function in group A (P<0.05). No significant difference (P>0.05) was detected between group A and group B in the same Child-Pugh class with respect to RE of the liver (20 min) and CNR of the common bile duct (50 min). This indicated that RE of the live and CNR of the common bile duct could be related mainly to the liver function, and perhaps minimally to the cholestasis and/or excretion dysfunction of intrahepatic small bile ducts.Conclusions: Gd-EOB-DTPA-enhanced MRI may aid in comprehensive assessment of the liver function in patients with PBC.
[Keywords] Magnetic resonance imaging；Gd-EOB-DTPA；Primary biliary cholangitis；Liver function

HAN Dan Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing100050, China

ZHANG Jie Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing100050, China

JIN Er-hu* Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing100050, China

HE Wen* Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing100050, China

YANG Zheng-han Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing100050, China

WANG Zhen-chang Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing100050, China

*Correspondence to: Jin EH, E-mail: erhujin@263.net He W, E-mail: hewen8080@ sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by the Health Industry Special Scientific Research Project No. 201402019
Received  2016-12-26
Accepted  2017-02-26
DOI: 10.12015/issn.1674-8034.2017.05.004
DOI:10.12015/issn.1674-8034.2017.05.004.

[1]
Selmi C, Bowlus CL, Gershwin ME, et al. Primary biliary cirrhosis. Lancet, 2011, 377(9777): 1600-1609.
[2]
Nguyen DL, Juran BD, Lazaridis KN. Primary biliary cirrhosis. Best Pract Res Clin Gastroenterol, 2010, 24(5): 647-654.
[3]
宋彬. 肝细胞特异性磁共振对比剂Gd-EOB-DTPA:新的机遇. 放射学实践, 2016, 31(1): 17-18.
[4]
Tateyama A, Fukukura Y, Takumi K, et al. Gd-EOB-DTPA-enhanced magnetic resonance imaging features of hepatic hemangioma compared with enhanced computed tomography. World J Gastroenterol, 2012, 18(43): 6269-6276.
[5]
Bashir MR, Gupta RT, Davenport MS, et al. Hepatocellular carcinoma in a North American population: does hepatobiliary MR imaging with Gd-EOB-DTPA improve sensitivity and confidence for diagnosis?J Magn Reson Imaging, 2013, 37(2): 398-406.
[6]
Tajima T, Akahane M, Takao H, et al. Detection of liver metastasis: is diffusion-weighted imaging needed in Gd-EOB-DTPA-enhanced MR imaging for evaluation of colorectal liver metastases?Jpn J Radiol, 2012, 30(8): 648-658.
[7]
An SK, Lee JM, Suh KS, et al. Gadobenate dimeglumine-enhanced liver MRI as the sole preoperative imaging technique: a prospective study of living liver donors. AJR Am J Roentgenol, 2006, 187(5): 1223-1233.
[8]
饶圣祥, 曾蒙苏. 肝特异性对比剂Gd-EOB-DTPA增强磁共振成像评价肝功能的研究进展. 世界华人消化杂志, 2016, 24(28): 3940-3945.
[9]
戴亚婕, 曾蒙苏. 特异性肝胆磁共振对比剂Gd-EOB-DTPA在胆道成像的临床应用及研究. 中国医学计算机成像杂志, 2014, 20(3): 291-294.
[10]
Lindor KD, Gershwin ME, Poupon R, et al. Primary biliary cirrhosis. Hepatology, 2009, 50(1): 291-308.
[11]
Heathcote EJ. Management of primary biliary cirrhosis: the american association for the study of liver diseases practice guidelines. Hepatology, 2000, 31(4): 1005-1013.
[12]
Purohit T, Cappell MS. Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy. World J Hepatol, 2015, 7(7): 926-941.
[13]
Marchioni Beery RM, Vaziri H, Forouhar F. Primary biliary cirrhosis and primary sclerosing cholangitis: a review featuring a women's health perspective. J Clin Transl Hepatol, 2014, 2(4): 266-284.
[14]
Gulamhusein AF, Juran BD, Lazaridis KN. Genome-wide association studies in primary biliary cirrhosis. Semin Liver Dis, 2015, 35(4): 392-401.
[15]
Padgett KA, Selmi C, Kenny TP, et al. Phylogenetic and immunological definition of four lipoylated proteins from Novosphingobium aromaticivorans, implications for primary biliary cirrhosis. J Autoimmun, 2005, 24(3): 209-219.
[16]
Shimizu J, Dono K, Gotoh M, et al. Evaluation of regional liver function by gadolinium-EOB-DTPA-enhanced MR imaging. Dig Dis Sci, 1999, 44(7): 1330-1337.
[17]
Papanikolaou N, Prassopoulos P, Eracleous E, et al. Contrast-enhanced magnetic resonance cholangiography versus heavily T2- weighted magnetic resonance cholangiography. Invest Radiol, 2001, 36(11): 682-686.
[18]
Do RK, Rusinek H, Taouli B. Dynamic contrast-enhanced MR imaging of the liver: current status and future directions. Magn Reson Imag Clin N Am, 2009, 17(2): 339-349.
[19]
Lee NK, Kim S, Kim GH, et al. Significance of the "delayed hyperintense portal vein sign" in the hepatobiliary phase MRI obtained with Gd-EOB-DTPA. J Magn Reson Imaging, 2012, 36(3): 678-685.
[20]
Gschwend S, Ebert W, Schultze-Mosgau M, et al. Pharmacokinetics and imaging properties of Gd-EOB-DTPA in patients with hepatic and renal impairment. Invest Radiol, 2011, 46(9): 556-566.
[21]
van Kessel CS, Veldhuis WB, van den Bosch MA, et al. MR liver imaging with Gd-EOB-DTPA: a delay time of 10 minutes is sufficient for lesion characterisation. Eur Radiol, 2012, 22(10): 2153-2160.
[22]
Vogl TJ, Kummel S, Hammerstingl R, et al. Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA. Radiology, 1996, 200(1): 59-67.
[23]
Dahlstrom N, Persson A, Albiin N, et al. Contrast-enhanced magnetic resonance cholangiography with Gd-BOPTA and Gd-EOB-DTPA in healthy subjects. Acta Radiologica, 2007, 48(4): 362-368.
[24]
Kanki A, Tamada T, Higaki A, et al. Hepatic parenchymal enhancement at Gd-EOB-DTPA-enhanced MR imaging: correlation with morphological grading of severity in cirrhosis and chronic hepatitis. Magn Reson Imaging, 2012, 30(3): 356-360.
[25]
Katsube T, Okada M, Kumano S, et al. Estimation of liver function using T1 mapping on Gd-EOB-DTPA-enhanced magnetic resonance imaging. Invest Radiol, 2011, 46(4): 277-283.
[26]
Motosugi U, Ichikawa T, Sou H, et al. Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA- enhanced MR imaging: which biological markers of the liver function affect the enhancement?J Magn Reson Imaging, 2009, 30(5): 1042-1046.
[27]
Tajima T, Takao H, Akai H, et al. Relationship between liver function and liver signal intensity in hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging. J Comput Assist Tomogr, 2010, 34(3): 362-366.
[28]
Nakamura S, Awai K, Utsunomiya D, et al. Chronological evaluation of liver enhancement in patients with chronic liver disease at Gd- EOB-DTPA-enhanced 3-T MR imaging: does liver function correlate with enhancement?Jpn J Radiol, 2012, 30(1): 25-33.
[29]
Nilsson H, Blomqvist L, Douglas L, et al. Assessment of liver function in primary biliary cirrhosis using Gd-EOB-DTPA-enhanced liver MRI. HPB (Oxford), 2010, 12(8): 567-576.
[30]
Huo TI, Lin HC, Wu JC, et al. Proposal of a modified Child-Turcotte- Pugh scoring system and comparison with the model for end-stage liver disease for outcome prediction in patients with cirrhosis. Liver Transpl, 2006, 12(1): 65-71.
[31]
Narita M, Hatano E, Arizono S, et al. Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma. J Gastroenterol, 2009, 44(7): 793-798.

PREV MRI T staging of nasopharyngeal carcinoma involving the fascial spaces of suprahyoid neck
NEXT MRI findings of primary hepatic neuroendocrine tumors: correlation with pathology
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn