Share：
Share this content in WeChat
X
[Chinese][PDF]85278
• Clinical Article •
MRI findings of primary hepatic neuroendocrine tumors: correlation with pathology
LIU Jun  LUO Jia-wen  BIAN Jie  KANG Yong-kun  TAO Juan  BAI Ting-ting 

DOI:10.12015/issn.1674-8034.2017.05.005.


[Abstract] Objective: To investigate MR imaging findings of primary hepatic neuroendocrine tumors (PHNETs) and their correlation with the 2010 WHO pathological classification.Materials and Methods: We analyzed MRI imagings of 6 patients who were diagnosed with PHNET and correlated the data with the 2010 WHO classification of neuroendocrine tumors.Results: According to the 2010 WHO classification system, 1 case was defined as G1, 3 cases were defined as G2, and 2 cases were defined as G3. The Grade 1 tumor was singular, solid nodules with prolonged enhancement from the arterial phase to the delayed phase. The lesion showed hypointensity on T1-weighted imaging, mildy high intensity on T2-weighted and homogeneous. The tumor cell arranged in a beam, and blood sinus was abundant. Grade 2 tumors could have a singular or multiple distribution pattern, signal intensities were heterogeneous on T1-and T2-weighted imaging with hemorrhage and necrosis. The tumor showed marked peripheral enhancement in the arterial phase and slight hyper-intensity relatived to the surrounding liver parenchyma in the delayed phase. Grade 3 tumors had multiple lesions, internal necrosis or coagulation necrosis, which showed the slight and prolonged enhancement from the arterial phase to the delayed phase. HE staining of the tumor showed tumor cell arranged as solid nests, and blood sinus was mildly abundant.Conclusions: MRI can reflect pathological features of PHNETs, which are helpful in accurately diagnosing PHNETs.
[Keywords] Neuroendocrine tumors；Liver neoplasms；Magnetic resonance imaging；Pathology

LIU Jun Department of Radiology, Dalian Municipal Central Hospital, Dalian 116033, China

LUO Jia-wen* Department of Radiology, The Second Hospital Of Dalian Medical University, Dalian 116023, China

BIAN Jie Department of Radiology, The Second Hospital Of Dalian Medical University, Dalian 116023, China

KANG Yong-kun Department of Radiology, The Second Hospital Of Dalian Medical University, Dalian 116023, China

TAO Juan Department of Radiology, The Second Hospital Of Dalian Medical University, Dalian 116023, China

BAI Ting-ting Department of Radiology, The Second Hospital Of Dalian Medical University, Dalian 116023, China

*Correspondence to: Luo JW, E-mail: kaoyan2006succeed@163.com

Conflicts of interest   None.

Received  2017-01-12
Accepted  2017-03-08
DOI: 10.12015/issn.1674-8034.2017.05.005
DOI:10.12015/issn.1674-8034.2017.05.005.

[1]
Chinese pathologic consensus group for gastrointestinal and pancreatic neuroendocrine neoplasms. Standardization in diagnosis of gastrointestinal and pancreatic neuroendocrine neoplasms: The Chinese consensus. Zhonghua Bing Li Xue Za Zhi, 2013, 42(10): 691-694.
[2]
Yao JC, Hassan M, Phan A, et al. One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35 825 cases in the United States. J Clin Oncol, 2008, 26(18): 3063-3072.
[3]
Gravante G, De LC, Overton J, et al. Primary carcinoids of the liver: a review of symptoms, diagnosis and treatments. DigSurg, 2008,25(5): 364-368.
[4]
Shen YH, Chen S, Zhang WT, et al. Clinical analysis of gastroenteropancreatic neuroendocrine tumor with liver metastasis, compared with primary hepatic neuroendocrine tumor. J Can Res Ther, 2014, 10(3): 276-280.
[5]
李晓琼, 张华, 李健丁. 肝脏原发神经内分泌肿瘤研究现状. 世界华人消化杂志, 2013, 21(11): 984-989.
[6]
Eriksson B, Oberg K, Stridsberg M. Tumor markers in neuroendocrine tumors. Digestion, 2000, 62(1): 33-38.
[7]
Van der Hoef M, Crook DW, Marincek B, et al. Primary neuroendocrine tumors of the liver: MRI features in two cases. Abdom Imaging, 2004, 29(1): 77-81.
[8]
Furrer J, Hattenschwiler A, Komminoth P, et al. Carcinoid syndrome, acromegaly, and hypoglycemia due to an insulin-secreting neuroendocrine tumor of the liver. J Clin Endocrinol Metab, 2001, 86(5): 2227-2230.
[9]
Iimuro Y, Deguchi Y, Ueda Y, et al. Primary hepatic carcinoid tumor with metachronous lymph node metastasis after long-term follow up. Gastroenterol Hepatol, 2002, 17(10): 1119-1124.
[10]
朱正、赵心明、周纯武. 肝脏原发神经内分泌癌的影像表现. 中国医学影像技术, 2010,26(4) : 721-723.
[11]
Wang LX, Liu K, Lin GW, et al. Primary hepatic neuroendocrine tumors:comparing CT and MRI features with pathology. Cancer Imaging, 2015, 15(1): 13.
[12]
Ishida M, Seki K, Tatsuzawa A, et al. Primary hepatic neuroendocrine carcinoma coexisting with hepatocellular carcinoma in hepatitis C liver cirrhosis:report of a case. Surg Today, 2003, 33(3): 214-218.
[13]
Kim JE, Lee WJ, Kim SH, et al. Three-phase helical computed tomographic findings of hepatic neuroendocrine tumors: pathologic correlation with revised WHO classification. J Comput Assist Tomogr, 2011, 35(6): 697-702.
[14]
陈财忠, 李若坤, 蒋杰, 等. 原发性肝脏神经内分泌癌的MRI表现与病理对照研究. 放射学实践, 2013, 28(12): 1267-1270.
[15]
赵心明, 欧阳汉, 周纯武. 肝细胞腺瘤的CT和MRI表现. 中国医学影像技术, 2005, 21(1): 80-82.

PREV Feasibility study of hepatobiliary-specific contrast agent Gd-EOB-DTPA-enhanced MRI in evaluating liver function of patients with primary biliary cholangitis
NEXT Rectal cancer on MRI diffusion-kurtosis imaging and correlation between DKI parameters and D2-40, CD31, S-100 and Ki-67 in rectal tumors
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn