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Initial application of fractional motion model in brain of anomalous diffusion
WANG Zhen-xiong  XU Bo-yan  ZHU Wen-zhen 

DOI:10.12015/issn.1674-8034.2017.05.011.


[Abstract] dMRI has been widely used in clinic, which is the only noninvasive method to research the diffusion processes in living tissue currently. The theory of traditional dMRI was based on the Brownian motion model, however, research has showed that the diffusion processes in crowded environments of biological cells are non-Brownian, also referred to as "anomalous diffusion". Several models have been proposed to explain anomalous diffusion phenomena in vivo and the fractional motion (FM) model is considered more appropriately among them. The model can not only reflect the anomalous diffusion of molecules in tissues but also provide rich information of subtle changes in organizational structure with its multiparameter (α, β, μ, H), thus guiding for disease diagnosis, treatment and prognosis. This article is aimed to review the imaging mechanism of FM model and initial application of FM model in brain of anomalous diffusion.
[Keywords] Diffusion magnetic resonance imaging；Anomalous diffusion；Brain

WANG Zhen-xiong Department of Radiology, Tongji Hospital Affiliated to Tongji Medical College ofHuazhong University of Science and Technology, Wuhan 430030, China

XU Bo-yan Magnetic Resonance Imaging Research Center of Peking University, Beijing 100871, China

ZHU Wen-zhen* Department of Radiology, Tongji Hospital Affiliated to Tongji Medical College ofHuazhong University of Science and Technology, Wuhan 430030, China

*Correspondence to: Zhu WZ, E-mail: zhuwenzhen8612@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This paper is funded by National Science Foundation of China No.81570462
Received  2017-02-16
Accepted  2017-04-18
DOI: 10.12015/issn.1674-8034.2017.05.011
DOI:10.12015/issn.1674-8034.2017.05.011.

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