Share：
Share this content in WeChat
X
[Chinese][PDF]82579
• Review •
Advances of quantitative dynamic contrast-enhanced MRI in rectal cancer
NIE Dan  GUO Liang 

DOI:10.12015/issn.1674-8034.2017.05.014.


[Abstract] Angiogenesis is an important factor of the genesis, progression and metastasis of rectal cancer. With low-molecular-weight gadolinium contrast agents, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can be used to evaluate the vascular characteristics non-invasively. Using fast T1-weighted imaging to continuously scan the region of interest, the time-signal intensity curve of the pixel in the region of interest was obtained. And the time-signal intensity curve was analyzed by using the pharmacokinetic model to calculate the perfusion parameters of rectal cancer, such as Ktrans, Ve, Kep, which can reflect the microcirculation permeability of the tissue or lesion of the region of interest. The basic principles of DCE-MRI, the advance in the research of the diagnosis, the classification and staging of rectal cancer with DCE-MRI at home and abroad are reviewed in the present paper.
[Keywords] Rectal neoplasms；Magnetic resonance imaging

NIE Dan Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China

GUO Liang* Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China

*Correspondence to: Guo L, E-mail: abcgliang@sina.com

Conflicts of interest   None.

Received  2016-12-10
Accepted  2017-03-20
DOI: 10.12015/issn.1674-8034.2017.05.014
DOI:10.12015/issn.1674-8034.2017.05.014.

[1]
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin, 2010, 62(1): 10-29.
[2]
Siegel RL, Miller KD, Fedewa SA, et al. Colorectal cancer statistics. 2017, Cancer J Clin, 2017. [ DOI: ]
[3]
孙应实, 张晓鹏, 唐磊, 等. 直肠癌局部浸润的高分辨率MRI征象与病理学T分期的对照研究. 中国医学影像技术, 2009, 25(3): 465-468.
[4]
van den Broek JJ, van der Wolf FS, Lahaye MJ, et al. Accuracy of MRI in Restaging Locally Advanced Rectal Cancer After Preoperative Chemoradiation. Dis Colon Rectum, 2017, 60(3): 274-283.
[5]
肖晓娟, 卢宝兰, 杨心悦, 等. 定量磁共振灌注成像用于评价直肠癌的微血管灌注及渗透性. 中国病理生理杂志, 2015, 31(12): 2164-2168.
[6]
Dvorak AM, Feng D. The vesiculo- vacuolar organelle (VVO): a new endothelial cell permeability organelle. J Histochem Cytochem, 2001, 49(4): 419-431.
[7]
王海屹, 叶慧义, 马林. 定量MR动态增强成像的机制及其在肿瘤学方面的应用价值. 中华放射学杂志, 2014, 48(3): 261-264.
[8]
Tran-Gia J, Bisdas S, Kostler H, et al. A model-based reconstruction technique for fast dynamic T1 mapping. Magn Reson Imaging, 2016, 34(3): 298-307.
[9]
Chikui T, Obara M, Simonetti AW, et al. The principal of dynamic contrast enhanced MRI, the method of pharmacokinetic analysis, and its application in the head and neck region. International J Dent, 2012, 2012: 480659.
[10]
Choi HS, Kim AH, Ahn SS, et al. Glioma grading capability: comparisons among parameters from dynamic contrast-enhanced MRI and ADC value on DWI. Korean J Radiol, 2013, 14(3): 487-492.
[11]
Tofts PS, Brix G, Buckley DL, et al. Estimating kinetic parameters from dynamic contrast-enhanced T 1-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging, 1999, 10(3): 223-232.
[12]
Rodjan F, De Graaf P, Van Der Valk P, et al. Retinoblastoma: value of dynamic contrast-enhanced MR imaging and correlation with tumor angiogenesis. Am J Neuroradiol, 2012, 33(11): 2129-2135.
[13]
Yao W, Zhang H, Ding B, et al. Rectal cancer: 3D dynamic contrast-enhanced MRI: correlation with microvascular density and clinicopathological features. Radiol Med, 2011, 116(3): 366-374.
[14]
Jeswani T, Padhani AR. Imaging tumour angiogenesis. Cancer Imaging, 2005, 5(1): 131-138.
[15]
Kim YE, Lim JS, Choi J, et al. Perfusion parameters of dynamic contrast-enhanced magnetic resonance imaging in patients with rectal cancer: correlation with microvascular density and vascular endothelial growth factor expression]. Korean J Radiol, 2013, 14(6): 878-885.
[16]
Brasch RC, Li KC, Husband JE, et al. In vivo monitoring of tumor angiogenesis with MR imaging. Acad Radiol, 2000, 7(10): 812-823.
[17]
George ML, Dzik-Jurasz AS, Padhani AR, et al. Non-invasive methods of assessing angiogenesis and their value in predicting response to treatment in colorectal cancer. Br J Surg, 2001, 88(12): 1628-1636.
[18]
Ahn SJ, An CS, Koom WS, et al. Correlations of 3T DCE-MRI quantitative parameters with microvessel density in a human-colorectal-cancer xenograft mouse model. Korean J Radiol, 2011, 12(6): 722-730.
[19]
Eberhard A, Kahlert S, Goede V, et al. Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies. Cancer Res, 2000, 60(5): 1388-1393.
[20]
Shin US, Yu CS, Kim JH, et al. Mucinous rectal cancer: effectiveness of preoperative chemoradiotherapy and prognosis. Ann Surg Oncol, 2011, 18(8): 2232-2239.
[21]
Oberholzer K, Menig M, Pohlmann A, et al. Rectal cancer: assessment of response to neoadjuvant chemoradiation by dynamic contrast-enhanced MRI. J Magn Reson Imaging, 2013, 38(1): 119-126.
[22]
谢宗源, 徐香玖, 黄刚, 等. 直肠癌DCE-MRI参数与病理特征的相关性研究. 磁共振成像, 2015, 6(4): 289-293.
[23]
顾晋. 浅析我国结直肠癌领域存在的问题. 中国医学前沿杂志(电子版), 2011, 3(6): 1-4.
[24]
杨晓棠, 张建新, 杜笑松, 等. 动态增强MRI定量与半定量分析在直肠癌术前T, N分期中的应用价值. 中华解剖与临床杂志, 21(2): 109-114.
[25]
Yeo DM, Oh SN, Jung CK, et al. Correlation of dynamic contrast -enhanced MRI perfusion parameters with angiogenesis and biologic aggressiveness of rectal cancer: preliminary results. J Magn Reson Imaging, 2015, 41(2): 474-480.
[26]
Langman G, Patel A, Bowley DM. Size and distribution of lymph nodes in rectal cancer resection specimens. Dis Colon Rectum, 2015, 58(4): 406-414.
[27]
Valentini V, Aristei C, Glimelius B, et al. Multidisciplinary rectal cancer management: 2nd European rectal cancer consensus conference (EURECA-CC2). Radiother Oncol, 2009, 92(2): 148-163.
[28]
Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med, 2004, 351(17): 1731-1740.
[29]
Maas M, Beets-Tan RG, Lambregts DM, et al. Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer. J Clin Oncol, 2011, 29(35): 4633-4640.
[30]
Allaix ME, Fichera A. Modern rectal cancer multidisciplinary treatment: the role of radiation and surgery. Ann Surg Oncol, 2013, 20(9): 2921-2928.
[31]
Tong T, Sun Y, Gollub MJ, et al. Dynamic contrast-enhanced MRI: use in predicting pathological complete response to neoadjuvant chemoradiation in locally advanced rectal cancer. J Magn Reson Imaging, 2015, 42(3): 673-680.
[32]
Intven M, Reerink O, Philippens ME. Dynamic contrast enhanced MR imaging for rectal cancer response assessment after neo-adjuvant chemoradiation. J Magn Reson Imaging, 2015, 41(6): 1646-1653.
[33]
Lim JS, Kim D, Baek SE, et al. Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer. Eur Radiol, 2012, 22(8): 1693-1700.
[34]
Kim SH, Lee JM, Gupta SN, et al. Dynamic contrast-enhanced MRI to evaluate the therapeutic response to neoadjuvant chemoradiation therapy in locally advanced rectal cancer. J Magn Reson Imaging, 2014, 40(3): 730-737.

PREV Research status of ASL perfusion imaging and dynamic contrast-enhanced MRI in the periphery of gliomas
NEXT Present situation and new progresses in magnetic resonance imaging of prostate cancer
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn