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• Clinical Article •
A preliminary study on evaluation of brain damage in acute phase of carbon monoxide intoxication with diffusion kurtosis imaging
TIAN Xiao-xue  GUO Shun-lin  ZHANG Yan-li  LEI Jun-qiang  WANG Shao-yu 

DOI:10.12015/issn.1674-8034.2017.06.005.


[Abstract] Objective: To explore the clinical value of MR diffusion kurtosis imaging (DKI) about diagnosing micro-changes of brain tissue in acute phase of CO intoxication.Materials and Methods: Routine MRI and DKI was performed in 26 cases with CO poisoning of acute stage (case group) and 18 healthy volunteers (control group). Analyze the relationships between DWI results and clinical factors. The study group was divided into two groups baesd on whether there had lesions detected in DWI images: positive and negative group. The DKI parameters of same brain area were compared separately between two case groups and control group. Analyze the correlation between ADC and two kinds of parameters of MD and MK in these differential parts of brain of case groups respectively if there were both differences in some areas.Results: ①The positive DWI scan results were affected by a long duration of disturbance of consciousness and a diminution of GCS score; ②Compared with the controls, in case groups there was a significantly reduced MD value of bilateral globus pallidus, centrum semiovale and periventricular white matter, corpus callosum genu, and MK values were increased in bilateral globus pallidus, thalamus, centrum semiovale and periventricular white matter. Thereinto, in positive and negative group, MD values of globus pallidus were significantly reduced while MK values were increased, and MK values of thalamus were also increased. Besides, in positive group FA values of globus pallidus were reduced; ③The results indicated that there was a strong correlation between MD or MK and ADC in case groups. The above differences were statistically significant (P<0.05).Conclusion: DKI techniques can reflect tiny structural changes of brain tissue in acute phase of CO intoxication, which will contribute to explaining features of brain damage from a micro level.
[Keywords] Carbon monoxide poisoning；Brain damage；Diffusion kurtosis imaging；Magnetic resonance imaging

TIAN Xiao-xue Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

GUO Shun-lin* Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

ZHANG Yan-li Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

LEI Jun-qiang Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

WANG Shao-yu MR Division, Siemens Healthcare Sector, Siemens Ltd. Shanghai 200000, China

*Correspondence to: Guo SL, E-mail: guoshunlin@msn.com

Conflicts of interest   None.

Received  2016-12-06
Accepted  2017-01-20
DOI: 10.12015/issn.1674-8034.2017.06.005
DOI:10.12015/issn.1674-8034.2017.06.005.

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