Share：
Share this content in WeChat
X
[Chinese][PDF]69571
• Clinical Article •
Degree centrality in different duration of patients with temporal lobe epilepsy
LI Ya-ping  GAO Yu-jun  GUO Dan-ni  ZHENG Jin-ou 

DOI:10.12015/issn.1674-8034.2017.07.001.


[Abstract] Objective: To study the changes of the level of brain function in patients with temporal lobe epilepsy (TLE), and to explore the relationship between them and the executive function using degree centrality (DC).Materials and Methods: The executive function of 21 patients with disease duration≤5 years, 19 cases of disease> 5 years of TLE patients and 30 healthy controls were studied by using attention network test (ANT). At the same time, the DC values of resting-state functional magnetic resonance imaging (rs-fMRI) were calculated, and the correlation between the DC values of the extracted brain regions and the efficiency of the control reaction was analyzed.Results: The efficiency of the control group was significantly lower than that of the control group (P<0.05). Compared with the control group, the brain area of the patients with less than 5-year-old group was located in the right hippocampus, and the brain area in the 5-year-old group was located in the right caudate nucleus, the left frontal lobe and the DC increased brain area was located on the left side of the central anterior, central posterior; course of disease> 5 years of patients than the course of ≤5 years of patients with DC increased brain area in the left island leaves. (cluster threshold at P<0.01, Alphasim corrected). The DC value of the right caudate nucleus in the 5-year group was negatively correlated with the efficiency of the control network (P<0.05).Conclusions: TLE patients with impaired function, different course of patients with brain area connection intensity (node) are different, different course of patients with executive function and different brain connection, only found in patients with longer course of the brain part of the existence of compensatory effect, and the functional connection intensity of the caudate nucleus is related to the execution function.
[Keywords] Epilepsy, temporal lobe；Executive function；Magnetic resonance imaging

LI Ya-ping Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China

GAO Yu-jun Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China

GUO Dan-ni Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China

ZHENG Jin-ou* Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China

*Correspondence to: Zheng JO, E-mail: jio2006@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by grants from the National Natural Science Foundation of China NO. 81560223 Guangxi Natural Science Foundation NO. 2015 GXNSFAA139129
Received  2017-03-17
Accepted  2017-06-07
DOI: 10.12015/issn.1674-8034.2017.07.001
DOI:10.12015/issn.1674-8034.2017.07.001.

[1]
Zheng JO, Yu L, Huang DH, et al. Reduced self-regulation of cerebrum contributes to executive impairment in patients with temporal lobe epilepsy. Int J Clin Exp Med, 2015, 8(6): 9610-9619.
[2]
Zuo XN, Ehmke R, Mennes M, et al. Network centrality in the human functional connectome. Cereb Cortex, 2012, 22(8): 1862-1875.
[3]
Baggio HC, Sala-Llonch R, Segura B, et al. Functional brain networks and cognitive deficits in Parkinson's disease. Hum Brain Mapp, 2014, 35(9): 4620-4634.
[4]
Sui X, Zhu M, Cui Y, et al. Functional connectivity hubs could serve as a potential biomarker in Alzheimer's disease: a reproducible study. Curr Alzheimer Res, 2015, 12(10): 974-983.
[5]
Fan J, McCandliss BD, Sommer T, et al. Testing the efficiency and independence of attentional networks. J Cogn Neurosci, 2002, 14(3): 340-347.
[6]
Tomasi D, Tomasi D, Shokri-Kojori E, et al. Temporal changes in local functional connectivity density reflect the temporal variability of the amplitude of low frequency fluctuations in gray matter. PLoS One, 2016, 11(4): e0154407.
[7]
Blumenfeld H. What is a seizure network? Long-range network consequences of focal seizures. Adv Exp Med Biol, 2014, 813: 63-70.
[8]
Goparaju B, Rana KD, Calabro FJ, et al. A computational study of whole-brain connectivity in resting state and task fMRI. Med Sci Monit, 2014, 20: 1024-1042.
[9]
Wang X, Jiao D, Zhang X, et al. Altered degree centrality in childhood absence epilepsy: a resting-state fMRI study. J Neurol Sci, 2017, 373: 274-279.
[10]
Diao L, Yu H, Zheng J, et al. Abnormalities of the uncinate fasciculus correlate with executive dysfunction in patients with left temporal lobe epilepsy. Magn Reson Imaging, 2015, 33(5): 544-550.
[11]
Park CH, Choi YS, Jung AR, al. Seizure control and memory impairment are related to disrupted brain functional integration in temporal lobe epilepsy. J Neuropsychiatry Clin Neurosci, 2017: appineuropsych16100216.
[12]
Bernson-Leung ME, Mazumdar M. Journal club: pretreatment EEG in childhood absence epilepsy. Neurology, 2014, 82(18): e158-160.
[13]
Shirer WR, Ryali S, Rykhlevskaia E, et al. Decoding subject-driven cognitive states with whole-brain connectivity patterns. Cereb Cortex, 2012, 22(1): 158-165.
[14]
Takeuchi H, Taki Y, Nouchi R, et al. Degree centrality and fractional amplitude of low-frequency oscillations associated with Stroop interference. Neuroimage, 2015, 119: 197-209.
[15]
Macfarlane MD, Looi JC, Walterfang M, et al. Executive dysfunction correlates with caudate nucleus atrophy in patients with white matter changes on MRI: a subset of LADIS. Psychiatry Res, 2013, 214(1): 16-23.

PREV MRI evaluation of hepatic iron overload: recent advances
NEXT Clinical study of magnetic resonance diffusion kurtosis imaging technology on half dark with acute cerebral infarction diagnosis value
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn