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• Clinical Article •
The quantitative study of dynamic contrast enhanced magnetic resonance in differentiating malignant and benign pulmonary lesions
SUI Xin  SONG Wei  XU Xiao-li  LIU Wei  WANG Shi-tian  JIANG Bo  WANG Xiao  SONG Lan  JIN Zheng-yu 

DOI:10.12015/issn.1674-8034.2017.07.006.


[Abstract] Objective: To estimate the diagnostic accuracy of dynamic contrast enhanced magnetic resonance (DCE-MR) images in the differential diagnosis between malignant and benign lung lesions.Materials and Methods: A total of thirty patients (male 13, female 17) with the presence of a newly detected solitary pulmonary lesion on CT, which was a solid nodule and needed further evaluation were included. All subjects were examined and underwent DCE-MR with CDT-VIBE. Ktrans、Kep、Ve and iAUC were calculated using the modified Tofts model.Results: In this study, 17 benign pulmonary lesions and 13 malignancies were found. The longest transverse diameter measured ranged from 1.1 to 5.3 cm. Malignancies had significantly higher Ktrans, Kep, iAUC than the benign lesions (P<0.05). The results of the ROC analysis showed AUC values for Ktrans (0.988), Kep (0.756), iAUC (0.806).Conclusions: Dynamic MR imaging reveals significant Ktrans, Kep, iAUC differences in perfusion between malignant and benign pulmonary lesions.
[Keywords] Lung neoplasms；Lung diseases；Magnetic resonance imaging；Dynamic contrast enhancement

SUI Xin Department of Radiology, Peking Union Medical College Hospital, Beijing 100730, China

SONG Wei Department of Radiology, Peking Union Medical College Hospital, Beijing 100730, China

XU Xiao-li Department of Radiology, Peking Union Medical College Hospital, Beijing 100730, China

LIU Wei Department of Radiology, Peking Union Medical College Hospital, Beijing 100730, China

WANG Shi-tian Department of Radiology, Peking Union Medical College Hospital, Beijing 100730, China

JIANG Bo Department of Radiology, Peking Union Medical College Hospital, Beijing 100730, China

WANG Xiao Department of Radiology, Peking Union Medical College Hospital, Beijing 100730, China

SONG Lan Department of Radiology, Peking Union Medical College Hospital, Beijing 100730, China

JIN Zheng-yu Department of Radiology, Peking Union Medical College Hospital, Beijing 100730, China

*Correspondence to: Song W, E-mail: cjr.songwei@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This project is supported by public welfare special fund for Industry Research No. 201402013
Received  2017-05-31
Accepted  2017-06-23
DOI: 10.12015/issn.1674-8034.2017.07.006
DOI:10.12015/issn.1674-8034.2017.07.006.

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