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• Clinical Article •
Multiple exponential models of diffusion weighted imaging in differentiating hepatocellular carcinoma from hepatic hemangioma
HAN Zheng  LIU Ai-lian  LIU Ze-qun  CHEN Li-hua  WANG He-qing  SUN Mei-yu  SONG Qing-wei 

DOI:10.12015/issn.1674-8034.2017.07.008.


[Abstract] Objective: To evaluate the feasibility of the monoexponential model of diffusion-weighted imaging (DWI), biexponential and stretched-exponential models of intravoxel incoherent motion (IVIM) and to compare the optimization in these models in differentiating hepatocellular carcinoma (HCC) from hepatic hemangioma (HH).Materials and Methods: Sixty-six patients under MR liver scanning were retrospectively enrolled in our hospital. All the patients were performed MRI exams on a 1.5 T scanner. For each region of interested (ROI), the mean values of DWI (ADC), eDWI (Standard ADC, D-mono, D*-mono, fmono, D-Bi、D*-Bi、fBi) and HB DWI (DDC, α) were measured.Results: The ADC, Standard ADC, D-mono, D*- mono, fmono, D-Bi, D*-Bi, fBi, DDC values of HCC and HH were statistically significant (P<0.05). The area under the ROC curve of ADC, Standard ADC, D-mono, fmono, D-Bi were higher than 0.9. The differential diagnostic efficiency with Standard ADC were significantly better than ADC. The differential diagnostic efficiency with ADC was significantly better than D*-Bi, fBi, HB DDC.Conclusions: The values of ADC, Standard ADC from monoexponential model, D-mono, fmono, D-Bi from double monoexponential model have favorable effective functions for the diagnosis, Standard ADC from monoexponential model with multiple b values were significantly better than ADC from monoexponential model with single b value in differential diagnosis of hepatocellular carcinoma and hepatic hemangioma.
[Keywords] Liver neoplasms；Diffusion magnetic resonance imaging；Intravoxel incoherent motion；Biexponential model；Stretched-exponential model

HAN Zheng Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China

LIU Ai-lian* Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China

LIU Ze-qun Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China

CHEN Li-hua Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China

WANG He-qing Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China

SUN Mei-yu Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China

SONG Qing-wei Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China

*Correspondence to: Liu AL, E-mail: cjr.liuailian@vip.163.com

Conflicts of interest   None.

Received  2017-02-07
Accepted  2017-04-18
DOI: 10.12015/issn.1674-8034.2017.07.008
DOI:10.12015/issn.1674-8034.2017.07.008.

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