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Mechanism changes of cognitive function and advances of structural and functional MRI in neuropsychiatric lupus
CHEN Da-jie  LU Jia-ming  ZHANG Xin  ZHANG Bing 

DOI:10.12015/issn.1674-8034.2017.07.012.


[Abstract] Central nervous system involvement in 25%—75% of systemic lupus erythematosus (SLE) patients, especially the brain, can produce a variety of neuropsychiatric symptoms. There is evidence that changes in olfactory and cognitive function may be earlier than the occurrence of neuropsychiatric symptoms, contributing to the early diagnosis of lupus encephalopathy. In recent years, various functional MRI (fMRI) techniques have important value for the diagnosis and evaluation of systemic lupus erythematosus and the occurrence and development of disease. This article reviews the changes in olfactory and cognitive aspects of patients with systemic lupus erythematosus and the application of structural and functional MRI.
[Keywords] Lupus erythematosus, systemic；Smell；Cognition；Magnetic resonance imaging

CHEN Da-jie Department of Radiology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

LU Jia-ming Department of Radiology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

ZHANG Xin Department of Radiology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

ZHANG Bing Department of Radiology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

*Correspondence to: Zhang B, E-mail: zhangbing_nanjing@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  The National Natural Science Fund No. 91649116, 81571040 Science and technology plan project social development fund of Jiangsu province No. BE2016605
Received  2017-04-18
Accepted  2017-05-15
DOI: 10.12015/issn.1674-8034.2017.07.012
DOI:10.12015/issn.1674-8034.2017.07.012.

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