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Clinical Article
The value of 3D-TOF-MRA for diagnosing rupturd intracranial aneurysm: a Meta analysis
WANG Li-li  LIU Hai-feng  GUO Shun-lin  GUO Ji-gang  ZHANG Hao  LEI Jun-qiang 

DOI:10.12015/issn.1674-8034.2017.09.001.


[Abstract] Objective: To evaluate the value of three-dimensional time of flight magnetic resonance angiography (3D-TOF-MRA) for diagnosing ruptured intracranial aneurysm (RIA) by Meta analysis.Materials and Methods: The studies concerning the diagnosis of RIA by 3D-TOF-MRA until December 2016 were searched in the databases such as CNKI, CBM, Wanfang data, VIP, the Cochrane Library, PubMed, Embase and Web of Science. Two reviewers independently screened literature, extracted data, and assessed risk of bias of included studies by using QUADAS-2 tool. Subsquently, Meta-analysis was performed through Stata 12.0 software. The pooled weighted sensitivity (SEN), specificity (SPE), Positive Likelihood (+LR), Negative Likelihood (-LR) and the diagnostic odds ratio (DOR) were calculated, summary receiver operating characteristic curve (SROC) was drawn.Results: A total of 13 articles consisting 15 studies were included, involving 1004 RIA patients and 1056 suspicious RIA cases. The results of Meta-analysis showed that, the pooled SEN, SPE, +LR, -LR, DOR and AUC of 3D-TOF-MRA for diagnosing RIA were Senmerge=0.94 [95% CI (0.91, 0.97)], Spemerge=0.94 [95% CI (0.87, 0.98)], +LRmerge=9.25[95% CI (5.28, 16.20)], -LRmerge=0.07 [95% CI (0.05, 0.12)], DORmerge=151.90 [95%CI (70.27, 328.37)], AUC=0.98, respectively. Results of subgroup showed 3D-TOF-MRA had better Sen in 3.0 T in comparation with 1.5 T (P<0.05), study type and study standard have no significant differences in RIA diagnosis (P>0.05).Conclusions: 3D-TOF-MRA has definite efficiency for assessing RIA, especially in high field study.
[Keywords] Intracranial aneurysm;Meta-analysis;Magnetic resonance angiography;Literature based discovery

WANG Li-li Radiology Department, the First Hospital of Lanzhou University, Lanzhou 730000, China

LIU Hai-feng Radiology Department, the First Hospital of Lanzhou University, Lanzhou 730000, China; First Clinical Medical College, Lanzhou University, Lanzhou 730000, China

GUO Shun-lin Radiology Department, the First Hospital of Lanzhou University, Lanzhou 730000, China

GUO Ji-gang Radiology Department, the First Hospital of Lanzhou University, Lanzhou 730000, China

ZHANG Hao Radiology Department, the First Hospital of Lanzhou University, Lanzhou 730000, China

LEI Jun-qiang* Radiology Department, the First Hospital of Lanzhou University, Lanzhou 730000, China

*Correspondence to: Lei JQ, E-mail: leijq1990@163.com

Conflicts of interest   None.

Received  2017-01-13
Accepted  2017-08-10
DOI: 10.12015/issn.1674-8034.2017.09.001
DOI:10.12015/issn.1674-8034.2017.09.001.

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