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• Clinical Article •
Comparative study of IVIM and 3D pCASL in the clinical staging of nasopharyngeal carcinoma
ZHANG Bo  ZHA Yun-fei  CHEN Zhong-qiang  WANG Jun 

DOI:10.12015/issn.1674-8034.2017.09.002.


[Abstract] Objective: To explore the application value of 3D pCASL (three-dimensional pseudo continuous arterial spin labeling) in the clinical staging of nasopharyngeal carcinoma with IVIM (intravoxel incoherent motion) double exponential model.Materials and Methods: We collected 36 cases of first diagnosed patients with nasopharyngeal carcinoma in our hospital. All patients underwent plain MR scan plus enhancement, multiple B diffusion weighted sequence and three-dimensional pseudo continuous arterial spin labeling sequence, and using Chinese 2008 staging system for staging, which was divided into high and low level group. The original data were sent to GEAW 4.6 workstation for post-processing to get D*, D, f and BFASL images, and the D*, D, f and BFASL values of the tumor parenchyma were measured. To compare the correlation between the parameters and the clinical stage of nasopharyngeal carcinoma.Results: In the BFASL and D* images, the tumors of the advanced group showed significantly high perfusion, while the low grade group showed a slightly higher or lower perfusion. In the total stage, T stage and N stage, the BFASL value and D* value of the advanced group were significantly higher than those of the lower level group, the f value was higher than that of the lower level group, and the D value was lower than that of the lower level group, which had statistical significance (P<0.05). BFASL value, D* value and f value were positively correlated with the total stage, T stage and N stage, D value was negatively correlated with the total stage, T stage and N stage. BFASL value and D* value, f value has a good positive correlation. BFASL, D*, f and D values in each clinical stage have good diagnostic efficacy, in the clinical stage, T stage and N stage, the BFASL value is the best, the ROC area is about 0.96, 0.94, 0.97.Conclusions: 3D pCASL and IVIM imaging both are noninvasive functional magnetic resonance perfusion. They can be a good evaluation of nasopharyngeal carcinoma, and predict clinical staging before treatment of nasopharyngeal carcinoma. The diagnostic efficacy of 3D pCASL was higher than that of IVIM.
[Keywords] Nasopharyngeal neoplasms；Neoplasm staging；Arterial spin labeling；Magnetic resonance imaging

ZHANG Bo Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

ZHA Yun-fei* Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

CHEN Zhong-qiang Department of Radiology, Suizhou Central Hospital of Hubei Province, Suizhou 441300, China

WANG Jun Department of Radiology, Suizhou Central Hospital of Hubei Province, Suizhou 441300, China

*Correspondence to: Zha YF, E-mail: zhayunfei999@126.com

Conflicts of interest   None.

Received  2017-03-16
Accepted  2017-06-05
DOI: 10.12015/issn.1674-8034.2017.09.002
DOI:10.12015/issn.1674-8034.2017.09.002.

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