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• Clinical Article •
The value of MR intravoxel incoherent motion diffusion weighted imaging in evaluating the degree of liver fibrosis of chronic hepatitis B
LI Chao  ZHU Shao-cheng  ZHANG Dan-xia  GUAN Shu 

DOI:10.12015/issn.1674-8034.2017.09.004.


[Abstract] Objective: To investigate the value of IVIM diffusion weighted imaging in the assessment of liver fibrosis in patients with chronic hepatitis B.Materials and Methods: Fifty-five cases of patients with chronic hepatitis B were divided into no and mild liver fibrosis group, moderate liver fibrosis group and severe liver fibrosis group according to liver biopsy pathology and selected 20 healthy volunteers as control group. All of the subjects have received 3.0 T magnetic resonance IVIM-DWI et al. The difference of sADC, D, D* and f value between the normal control group and the liver fibrosis group and between the liver fibrosis groups were statistically analyzed.Results: With the progression of liver fibrosis, the D, D* and f value of liver were gradually reduced. There was signicficant difference in D value between the normal control group and the liver fibrosis group. There was signicficant difference in D* and f value between the normal control group and the liver fibrosis group and between the liver fibrosis groups. The D, D* and f values in normal control group and liver fibrosis group respectively were (0.540±0.031)×10-3 mm2/s and (0.427±0.061)×10-3 mm2/s, (0.380±0.027)×10-1 mm2/s and (0.320±0.052)×10-1 mm2/s, (0.232±0.014) and (0.217±0.011). The D, D* and f values in no and mild liver fibrosis group respectively were (0.489±0.027)×10-3 mm2/s, (0.349±0.041)×10-1 mm2/s, (0.226±0.010). The D, D* and f values in moderate liver fibrosis group respectively were (0.398±0.035)×10-3 mm2/s, (0.317±0.040)×10-1 mm2/s, (0.214±0.008). The D, D* and f values in severe liver fibrosis group respectively were (0.370±0.048)×10-3 mm2/s, (0.269±0.055)×10-1 mm2/s, (0.206±0.006).Conclusions: The parameters D, D* and f value of MR IVIM-DWI can approximately reflect the severity of liver fibrosis in patients with chronic hepatitis B, has potential value in clinical application, especially can be used for the noninvasive assessment of liver fibrosis in the early stage.
[Keywords] Hepatitis B；Liver fibrosis；Magnetic resonance imaging

LI Chao Graduate Department of Xinxiang Medical University, Xinxiang 453003, China; Department of Radiology, People's Hospital of Henan Province, Zhengzhou 450003, China

ZHU Shao-cheng* Department of Radiology, People's Hospital of Henan Province, Zhengzhou 450003, China

ZHANG Dan-xia Graduate Department of Xinxiang Medical University, Xinxiang 453003, China; Department of Radiology, People's Hospital of Henan Province, Zhengzhou 450003, China

GUAN Shu Graduate Department of Xinxiang Medical University, Xinxiang 453003, China; Department of Radiology, People's Hospital of Henan Province, Zhengzhou 450003, China

*Correspondence to: Zhu SC, E-mail: zsc2686@163.com

Conflicts of interest   None.

Received  2017-03-30
Accepted  2017-07-21
DOI: 10.12015/issn.1674-8034.2017.09.004
DOI:10.12015/issn.1674-8034.2017.09.004.

[1]
Sandrascgaran K, Tahir B, Patel A, et al. The usefulness of diffusion-weighted imaging in the characterization of liver lesions in patients with cirrhosis. Clin Radiol, 2013, 68(7): 708-715.
[2]
邓乾华，阮继银，江锦赵,等.磁共振扩散加权成像在家兔肝纤维化分期的诊断价值.磁共振成像, 2015, 6(6): 467-470.
[3]
Le Bihan D, Breton E, Lallemand D, et al. Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology, 1988, 168(2): 497-505.
[4]
中华医学会肝病学分会，中华医学会感染病学分会.慢性乙型肝炎防治指南(2015年更新版).临床肝胆病杂志, 2015, 31(12):1941-1960.
[5]
Scheuer PJ. Classification of chronic viral hepatitis: a need for reassessment. J Hepatol, 1991, 13(3): 372-374.
[6]
Chow AM, Gao DS, Fan SJ, et al. Liver fibrosis:an intravoxel incoherent motion (IVIM) study. J Magn Reson Imaging, 2012, 36(1): 159-167.
[7]
Huseyin O, Firat K, Ozan K, et al. Diffusion Weighted MRI for Hepatic Fibrosis: impact of b-Value. Iran J Radiol, 2014,11(1): e3555.
[8]
Kim BH, Lee JM, Lee YJ, et al. MR elastography for noninvasive assessment of hepatic fibrosis: experience from a tertiary center in Asia. J Magn Reson Imaging, 2011, 34(5): 1110-1116.
[9]
李秋菊，李加慧，赵周社,等. DWI多b值水通道蛋白分子成像在肝纤维化早期诊断的价值.中国临床医学影像杂志, 2014, 25(10):719-723.
[10]
Annet L, Peeters F, Abarca-Quinones J, et al. Assessment of diffusion-weighted MR imaging in liver fibrosis. J Magn Reson Imaging, 2007, 25(1): 122-128.
[11]
胡根文，全显跃，林小影,等.磁共振单指数ADC值及扩散峰度成像在大鼠肝纤维化模型中的应用.中国医学影像技术, 2015,31(4): 493-497.
[12]
Taouli B, Chouli M, Martin AJ, et al. Chronic hepatitis: role of diffusion-weighted imaging and diffusion tensor imaging for the diagnosis of liver fibrosis and inflammation. J Magn Reson Imaging, 2008, 28(1): 89-95.
[13]
Tosun M, Inan N, Sarisoy HT, et al. Diagnostic performance of conventional diffusion weighted imaging and diffusion tensor imaging for the liver fibrosis and inflammation. Eur J Radiol,2013(82): 203-207.
[14]
Le Bihan D, Breton E, Lallemand D, et al. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology, 1986,161(2): 401-407.
[15]
Aubé C. Imaging modalities for the diagnosis of hepatic fibrosis and Cirrhosis. Clin Res Hepatol Gastroenterol, 2015, 39(1): 38-44.
[16]
Taouli B, Koh DM. Diffusion-weighted MR imaging of the liver. Radiology, 2010, 254(1): 47-66.
[17]
Vaziri-Bozorg SM, Ghasemi-Esfe AR, Khalilzadeh O, et al. Diffusion-weighted magnetic resonance imaging for diagnosis of liver fibrosis and inflammation in chronic viral hepatitis: the performance of low or high b values and small or large regions of interest. Can Assoc Radiol J, 2012, 63(4): 304-311.
[18]
Yoon JH, Lee JM, Baek JH, et al. Evaluation of hepatic fibrosis using intravoxel incoherent motion in diffusion-weighted liver MRI.J Comput Assist Tomogr, 2014, 38(1): 110-116.
[19]
Zhao F, Yuan J, Deng M, et al. Further exploration of MRI techniques for liver T1rho quantification. Quant Imaging Med Surg, 2013, 3(6):308-315.
[20]
Ellis EL, Mann DA. Clinical evidence for the regression of liver fibrosis. J Hepatol, 2012, 56(5): 1171-1180.
[21]
Koinuma M, Ohashi I, Hanafusa K, et al. Apparent diffusion coefficient measurements with diffusion-weighted magnetic resonance imaging for evaluation of hepatic fibrosis. J Magn Reson Imaging, 2005, 22(1): 80-85.
[22]
Boulanger Y, Amara M, Lepanto L, et al. Diffusion-weighted MR imaging of the liver of hepatitis C patients. NMR Biomed, 2003, 16(3): 132-136.
[23]
Robin B, Birger M, Peter M, et al. Diffusion-weighted magnetic resonance imaging for staging liver fibrosis is less reliable in the presence of fat and iron. Eur Radiol, 2013, 23(5): 1281-1287.
[24]
FrancM, Luis Martı-Bonmati L, Alberich-Bayarri A, et al. Evaluation of fibrosis and inflammation in diffuse liver diseases using intravoxel incoherent motion diffusion-weighted MR Imaging. Abdom Radiol, 2017, 42(2): 468-477.
[25]
梁真，刘钢涛，蓝柏钊,等.乙肝相关肝纤维化发病机制研究新进展.大众科技, 2015, 17(194): 78-80.
[26]
曾政，陆普选，黄华.磁共振体素内不相干运动成像诊断肝纤维化的初步研究.放射学实践, 2015, 30(7): 775-778.
[27]
Lu PX, Huang H, Yuan J, et al. Decreases in molecular diffusion, perfusion fraction and perfusion-related diffusion in fibrotic livers: a prospective clinical intravoxel incoherent motion MR imaging Study. Plos one, 2014, 9(12): e113846.
[28]
Patel J, Sigmund EE, Rusinek H, et al. Diagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast-enhanced MRI alone and in combination: preliminary experience. J Magn Reson Imaging, 2010, 31(3): 589-600.
[29]
张莎莎，吕文良，张旭,等.肝纤维化的发病机制研究进展.浙江中医药大学学报. 2011, 35(5): 797-802.
[30]
Seto WK, Lai CL, Ip PP, et al. A large population histology study showing the lack of associationg between ALT elevation and significant fibrosis in chronic hepatitis B. Plos One, 2012, 7(2):e32622.
[31]
Dyvorne HA, Galea N, Nevers T, et al. Diffusion-weighted imaging of the liver with multiple b values: effect of diffusion gradient polarity and breathing acquisition on image quality and intravoxel incoherent motion parameters: a pilot study. Radiology, 2013, 266(3):920-929.
[32]
Kovac JD, Jesic R, Stanisavljevic D, et al. Integrative role of MRI in the evaluation of primary biliary cirrhosis. Eur Radiol, 2012, 22(3): 688-694.
[33]
邓宇，梁长虹，伍筱梅,等.体素内不相干运动磁共振扩散加权成像诊断兔非酒精性脂肪肝病.中国医学影像技术, 2016, 32(7):1000-1004.
[34]
Guan S, Zhou KR, Zhao WD, et al. Magnetic resonance diffusion-weighted imaging in the diagnosis of diffuse liver diseases in rats. Chin Med J, 2005, 118(8): 639-644.

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