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• Clinical Article •
The value of MR intravoxel incoherent motion diffusion weighted imaging in evaluating the degree of liver fibrosis of chronic hepatitis B
LI Chao  ZHU Shao-cheng  ZHANG Dan-xia  GUAN Shu 

DOI:10.12015/issn.1674-8034.2017.09.004.


[Abstract] Objective: To investigate the value of IVIM diffusion weighted imaging in the assessment of liver fibrosis in patients with chronic hepatitis B.Materials and Methods: Fifty-five cases of patients with chronic hepatitis B were divided into no and mild liver fibrosis group, moderate liver fibrosis group and severe liver fibrosis group according to liver biopsy pathology and selected 20 healthy volunteers as control group. All of the subjects have received 3.0 T magnetic resonance IVIM-DWI et al. The difference of sADC, D, D* and f value between the normal control group and the liver fibrosis group and between the liver fibrosis groups were statistically analyzed.Results: With the progression of liver fibrosis, the D, D* and f value of liver were gradually reduced. There was signicficant difference in D value between the normal control group and the liver fibrosis group. There was signicficant difference in D* and f value between the normal control group and the liver fibrosis group and between the liver fibrosis groups. The D, D* and f values in normal control group and liver fibrosis group respectively were (0.540±0.031)×10-3 mm2/s and (0.427±0.061)×10-3 mm2/s, (0.380±0.027)×10-1 mm2/s and (0.320±0.052)×10-1 mm2/s, (0.232±0.014) and (0.217±0.011). The D, D* and f values in no and mild liver fibrosis group respectively were (0.489±0.027)×10-3 mm2/s, (0.349±0.041)×10-1 mm2/s, (0.226±0.010). The D, D* and f values in moderate liver fibrosis group respectively were (0.398±0.035)×10-3 mm2/s, (0.317±0.040)×10-1 mm2/s, (0.214±0.008). The D, D* and f values in severe liver fibrosis group respectively were (0.370±0.048)×10-3 mm2/s, (0.269±0.055)×10-1 mm2/s, (0.206±0.006).Conclusions: The parameters D, D* and f value of MR IVIM-DWI can approximately reflect the severity of liver fibrosis in patients with chronic hepatitis B, has potential value in clinical application, especially can be used for the noninvasive assessment of liver fibrosis in the early stage.
[Keywords] Hepatitis B；Liver fibrosis；Magnetic resonance imaging

LI Chao Graduate Department of Xinxiang Medical University, Xinxiang 453003, China; Department of Radiology, People's Hospital of Henan Province, Zhengzhou 450003, China

ZHU Shao-cheng* Department of Radiology, People's Hospital of Henan Province, Zhengzhou 450003, China

ZHANG Dan-xia Graduate Department of Xinxiang Medical University, Xinxiang 453003, China; Department of Radiology, People's Hospital of Henan Province, Zhengzhou 450003, China

GUAN Shu Graduate Department of Xinxiang Medical University, Xinxiang 453003, China; Department of Radiology, People's Hospital of Henan Province, Zhengzhou 450003, China

*Correspondence to: Zhu SC, E-mail: zsc2686@163.com

Conflicts of interest   None.

Received  2017-03-30
Accepted  2017-07-21
DOI: 10.12015/issn.1674-8034.2017.09.004
DOI:10.12015/issn.1674-8034.2017.09.004.

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