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• Clinical Article •
Intravoxel incoherent motion diffusion weighted magnetic resonance imaging for differentiation between benign and malignant thyroid nodules
AI Zhao-dong  HOU Jing  LI Fei-ping  LU Qiang  ZHANG Zhi-yuan  CHEN Jie  YU Xiao-ping 

DOI:10.12015/issn.1674-8034.2017.10.005.


[Abstract] Objective: This study aimed to investigate the value of intravoxel incoherent motion (IVIM) diffusion weighted magnetic resonance for differentiation between the benign and malignant thyroid nodules.Materials and Methods: Thirty-two patients with forty-four thyroid nodules (benign nodules 23, malignant nodules 21) underwent conventional MRI sequences and IVIM sequence before operation. The ADCstandard (standard ADC), ADCslow (slow ADC), ADCfast (fast ADC) and f (fraction of fast ADC) values of benign and malignant thyroid nodules were compared. Diagnostic threshold and efficacy of these parameters for benign and malignant thyroid nodules were evaluated by receiver operating characteristic (ROC) curve.Results: The ADCstandard, ADCslow, f values of malignant thyroid nodule group were lower than those of benign nodule group, while ADCfast value was higher than that of the benign nodule group, and the ADCstandard and ADCslow values were statistically significant difference between the benign and malignant thyroid nodules (P≤0.003). The area under the curve of ADCslow was higher than ADCstandard, which was 0.808, and the sensitivity, specificity were 71.43%, 86.96% respectively; the area under the curve of ADCstandard was 0.759, the sensitivity, specificity were 80.95%, 60.87% respectively. ADCfast and f values were not statistically significant difference between the two groups.Conclusion: The ADCstandard and ADCslow values were valuable for differentiating benign and malignant thyroid nodules. The area under ROC curve of the ADCslow value is higher than that of the ADCstandard value.
[Keywords] Thyroid nodule；Intravoxel incoherent motion；Diffusion weighted imaging；Pathology；Magnetic resonance imaging

AI Zhao-dong Department of Diagnostic Radiology, Hunan cancer hospital, Changsha 410013, China

HOU Jing Department of Diagnostic Radiology, Hunan cancer hospital, Changsha 410013, China

LI Fei-ping Department of Diagnostic Radiology, Hunan cancer hospital, Changsha 410013, China

LU Qiang Department of Diagnostic Radiology, Hunan cancer hospital, Changsha 410013, China

ZHANG Zhi-yuan Department of Diagnostic Radiology, Hunan cancer hospital, Changsha 410013, China

CHEN Jie Departmem of Head and Neck Surgery, Hunan cancer hospital, Changsha 410013, China

YU Xiao-ping* Department of Diagnostic Radiology, Hunan cancer hospital, Changsha 410013, China

*Correspondence to: Yu XP, E-mail: yuxiaoping@hnszlyy.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Provincial Key Clinical Specialty (Medical Imaging) Development Program from Health and Family Planning Commission of Hunan Province No. 2015-43
Received  2017-04-07
Accepted  2017-06-25
DOI: 10.12015/issn.1674-8034.2017.10.005
DOI:10.12015/issn.1674-8034.2017.10.005.

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