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Research advances in MEMRI for monitoring intracellular Ca2+ change at the early stage of MODS
JIN Bo  ZHAO Da-wei  WANG Yi 

DOI:10.12015/issn.1674-8034.2017.10.012.


[Abstract] Manganese ion (Mn2+) has been applied for quite a few animal experiments for more than thirty years as a contrast agent of magnetic resonance imaging (MRI), duo to its sensitivity for a number of biological processes, manganese-enhanced MRI (MEMRI) made great progress in a multitude of biological researches in recent years, mainly including three aspects: contrast enhancement of subtle anatomical structure, activity-induced manganese-enhanced MRI (AIM-MRI) and tracing neural circuits or special neuronal connectivity. The application of MEMRI is primarily based on the following three properties of Mn2+: as an analogue of calcium ion (Ca2+), Mn2+ could enter into excitable cells via L-type voltage gated calcium channels; paramagnetic Mn2+ can shorten longitudinal relaxation time of water protons and result in positive MRI T1 enhancement effect; Mn2+ entered into neurons and can traverse synapses to accumulate in neighboring neurons by microtubule-dependent axonal transport. Multiple organ dysfunction syndrome (MODS), has a very high mortality rate, and it is a pointcut for the treatment of MODS to understand its mechanisms and timely to hinder the developing process. Intracellular Ca2+ overload is one of the key events during MODS, and basing on the relative biological properties of Mn2+, MEMRI might have the potential to monitor dynamically some relative pathophysiological progresses at the early stage of MODS in vivo, and it’s possible to further explore its mechanisms and evaluate effect of treatment.
[Keywords] Manganese ion；Calcium overload；Magnetic resonance imaging；Multiple organ injury；Mutiple organ dysfunction syndrome

JIN Bo Department of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China

ZHAO Da-wei Department of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China

WANG Yi* Department of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China

*Correspondence to: Wang Y, E-mail: 909801791@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81671943
Received  2017-06-13
Accepted  2017-09-06
DOI: 10.12015/issn.1674-8034.2017.10.012
DOI:10.12015/issn.1674-8034.2017.10.012.

[1]
Fukutake T, Yano H, Kushida R, et al. Early detection of manganese intoxication based on occupational history and T1-weighted MRI. Brain Nerve, 2016, 68(2): 175-180.
[2]
Long Z, Jiang YM, Li XR, et al. Vulnerability of welders to manganese exposure: a neuroimaging study. Neurotoxicology, 2014,45(12): 285-292.
[3]
Wolf GL, Baum L. Cardiovascular toxicity and tissue proton T1 response to manganese injection in the dog and rabbit. AJR, 1983,141(1): 193-197.
[4]
Chen Y, Shi CY, Li Y, et al. Ability of Mn2+ to permeate the eye and availability of manganese-enhanced magnetic resonance imaging for visual pathway imaging via topical administration. Chin Med J (Engl), 2016, 129(15): 1822-1829.
[5]
Aime S, Anelli L, Botta M, et al. Relaxometric evaluation of novel manganese (II) complexes for application as contrast agents in magnetic resonance imaging. J Biol Inorg Chem, 2002, 7(1-2):58-67.
[6]
Federle M, Chezmar J, Rubin DL, et al. Efficacy and safety of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: results of the U.S. Multicenter phase III clinical trials. Efficacy of early imaging. J Magn Reson Imaging, 2000, 12(5):689-701.
[7]
Silva AC, Lee JH, Aoki I, et al. Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations. NMR Biomed, 2004, 17(8): 532-543.
[8]
Hallam TJ, Rink TJ. Agonists stimulate divalent cation channels in the plasma membrane of human platelets. FEBS Lett, 1985, 186(2):175-179.
[9]
Shibuya I, Douglas WW. Indications from Mn-quenching of Fura-2 fluorescence in melanotrophs that dopamine and baclofen close Ca channels that are spontaneously open but not those opened by high [K+]O; and that Cd preferentially blocks the latter. Cell Calcium, 1993, 14(1): 33-44.
[10]
Lin YJ, Koretsky AP. Manganese ion enhances T1-weighted MRI during brain activation: an approach to direct imaging of brain function. Magn Reson Med, 1997, 38(3): 378-388.
[11]
Silva AC. Using manganese-enhanced MRI to understand BOLD. Neuroimage, 2012, 62(2): 1009-1013.
[12]
陈亦刚.多器官功能障碍综合征病理生理的研究进展.医学新知杂志, 2015, 25(6): 420-425.
[13]
Zavodnik IB. Mitochondria, calcium homeostasis and calcium signaling. Biomed Khim, 2016, 62(3): 311-317.
[14]
Carafoli E, Krebs J. Why calcium? How calcium became the best communicator. J Biol Chem, 2016, 291(40): 20849-20857.
[15]
Dutton RP. Current concepts in hemorrhagic shock. Anesthesiol Clin, 2007, 25(1): 23-34.
[16]
Ma HJ, Li Q, Ma HJ, et al. Chronic intermittent hypobaric hypoxia ameliorates ischemia/reperfusion-induced calcium overload in heart via Na+/Ca2+ exchanger in developing rats. Cell Physiol Biochem, 2014, 34(2): 313-324.
[17]
Murphy E, Steenbergen C. Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol Rev, 2008, 88(2): 581-609.
[18]
Riemensperger T, Pech U, Dipt S, et al. Optical calcium imaging in the nervous system of Drosophila melanogaster. Biochim Biophys Acta, 2012, 1820(8): 1169-1178.
[19]
Sargoy A, Barnes S, Brecha NC, et al. Immunohistochemical and calcium imaging methods in wholemount rat retina. J Vis Exp, 2014,92(13): e51396.
[20]
Minocci D, Carbognin E, Murmu MS, et al. In vivo functional calcium imaging of induced or spontaneous activity in the fly brain using a GFP-apoaequorin-based bioluminescent approach. Biochim Biophys Acta, 2013, 1833(7): 1632-1640.
[21]
Jasanoff A. MRI contrast agents for functional molecular imaging of brain activity. CurrOpin Neurobiol, 2007, 17(5): 593-600.
[22]
Atanasijevic T, Jasanoff A. Preparation of iron oxide-based calcium sensors for MRI. Nature Protocols, 2007, 2(10): 2582-2589.
[23]
Aguor EN, Arslan F, van de Kolk CW, et al. Quantitative T2* assessment of acute and chronic myocardial ischemia/reperfusion injury in mice. MAGMA, 2012,25(5):369-379.
[24]
Wypych-Klunder K, Adamowicz A, Lemanowicz A, et al. Diffusion-weighted MR imaging of transplanted kidneys: preliminary report. Pol J Radiol, 2014, 79(5): 94-98.
[25]
Waghorn B, Schumacher A, Liu J, et al. Indirectly probing Ca2+ handling alterations following myocardial infarction in a murine model using T1-mapping manganese enhanced magnetic resonance imaging. Magn Reson Med, 2011, 65(1): 239-249.
[26]
Cross DJ, Flexman JA, Anzai Y, et al. In vivo manganese MR imaging of calcium influx in spontaneous rat pituitary adenoma. AJNR, 2007, 28(10): 1865-1871.
[27]
Waghorn B, Edwards T, Yang Y, et al. Monitoring dynamic alterations in calcium homeostasis by T1-weighted and T1-mapping cardiac manganese-enhanced MRI in a murine myocardial infarction model. NMR Biomed, 2008, 21(10): 1102-1111.
[28]
Andrews M, Giger ML, Roman BB. Manganese-enhanced MRI detection of impaired calcium regulation in a mouse model of cardiac hypertrophy. NMR Biomed, 2015, 28(2): 255-263.
[29]
Zhao DW, Cheng C, Kuang LQ, et al. A new approach using manganese-enhanced MRI (MEMRI) to diagnose acute mesenteric ischemia in a rabbit model: initial experience. Biomed Res Int, 2015, 2015(579639): 1-7.
[30]
Zhao DW, Zhang LT, Cheng HY, et al. Monitoring dynamic alterations in calcium homeostasis by T1-mapping manganese-enhanced MRI (MEMRI) in early stage of small intestinal ischemia-reperfusion injury. NMR Biomed, 2015, 28(8): 958-966.
[31]
Ong CL, Potter AJ, Trappetti C, et al. Interplay between manganese and iron in pneumococcal pathogenesis: role of the orphan response regulator RitR. Infect Immun, 2013, 81(2): 421-429.
[32]
杨军，李勤劫，丁莹莹,等.锰离子增强MRI在显示大鼠视觉传导通路中的最佳时间.中国医学影像技术, 2015, 31(9): 1295-1299.
[33]
Delattre BM, Braunersreuther V, Hyacinthe JN, et al. Myocardial infarction quantification with Manganese-Enhanced MRI (MEMRI) in mice using a 3.0 T clinical scanner. NMR Biomed, 2010, 23(5): 503-513.

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